DE69018529T2 - Phospholipase A2-Inhibitor, Mikroorganismen, die diesen Inhibitor erzeugen und mehrere Verfahren zu seiner Herstellung. - Google Patents
Phospholipase A2-Inhibitor, Mikroorganismen, die diesen Inhibitor erzeugen und mehrere Verfahren zu seiner Herstellung.Info
- Publication number
- DE69018529T2 DE69018529T2 DE69018529T DE69018529T DE69018529T2 DE 69018529 T2 DE69018529 T2 DE 69018529T2 DE 69018529 T DE69018529 T DE 69018529T DE 69018529 T DE69018529 T DE 69018529T DE 69018529 T2 DE69018529 T2 DE 69018529T2
- Authority
- DE
- Germany
- Prior art keywords
- inhibitor
- phospholipase
- production
- coor
- microorganisms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17039689 | 1989-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69018529D1 DE69018529D1 (de) | 1995-05-18 |
DE69018529T2 true DE69018529T2 (de) | 1996-03-21 |
Family
ID=15904154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69018529T Expired - Fee Related DE69018529T2 (de) | 1989-06-30 | 1990-06-22 | Phospholipase A2-Inhibitor, Mikroorganismen, die diesen Inhibitor erzeugen und mehrere Verfahren zu seiner Herstellung. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5099034A (de) |
EP (1) | EP0405864B1 (de) |
JP (1) | JPH03108490A (de) |
KR (1) | KR910001037A (de) |
AT (1) | ATE121091T1 (de) |
DE (1) | DE69018529T2 (de) |
DK (1) | DK0405864T3 (de) |
ES (1) | ES2073529T3 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5132320A (en) * | 1990-03-21 | 1992-07-21 | Merck & Co., Inc. | Squalene synthetase inhibitors |
US5096923A (en) * | 1990-03-21 | 1992-03-17 | Merck & Co., Inc. | Novel squalene synthetase inhibitors |
US5278064A (en) * | 1991-08-01 | 1994-01-11 | Eli Lilly And Company | Amycolatopsis mediterranei strains useful to prepare A87689 compounds |
US5350579A (en) * | 1991-08-01 | 1994-09-27 | Eli Lilly And Company | A87689 compounds employed as a phospholipase A2 (PLA2) inhibitor to treat inflammatory diseases |
US5254727A (en) * | 1992-10-19 | 1993-10-19 | Merck & Co., Inc. | Acyclic tricarboxylic acid compounds |
GB9226724D0 (en) * | 1992-12-22 | 1993-02-17 | Xenova Ltd | Pharmaceutical compounds |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
AU4343500A (en) | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
CA2434430A1 (en) * | 2001-01-26 | 2002-08-01 | Harry R. Davis | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
RS51449B (sr) * | 2001-01-26 | 2011-04-30 | Schering Corporation | Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
US20030053981A1 (en) * | 2001-01-26 | 2003-03-20 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
NZ542090A (en) * | 2001-01-26 | 2006-09-29 | Schering Corp | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
TW200840563A (en) * | 2001-01-26 | 2008-10-16 | Schering Corp | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications |
US20030013699A1 (en) * | 2001-05-25 | 2003-01-16 | Davis Harry R. | Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject |
DE60216300T2 (de) * | 2001-09-21 | 2007-06-28 | Schering Corp. | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
CN1556700A (zh) * | 2001-09-21 | 2004-12-22 | ���鹫˾ | 使用甾醇吸收抑制剂治疗或预防脉管炎的方法 |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
WO2003101177A2 (en) * | 2002-06-04 | 2003-12-11 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
AU2003248794B2 (en) * | 2002-06-27 | 2007-10-04 | Harkness Pharmaceuticals, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
AU2003291719A1 (en) * | 2002-11-06 | 2004-06-03 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
JP5137228B2 (ja) * | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
DE602004018617D1 (de) * | 2003-03-07 | 2009-02-05 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
WO2005046797A2 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
JP4606209B2 (ja) * | 2005-03-10 | 2011-01-05 | ダイセル化学工業株式会社 | ラクトン化合物及びラクトン化合物の製造法 |
US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
US7897800B2 (en) * | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
ES2328214B1 (es) | 2008-05-06 | 2010-07-23 | Consejo Superior De Investigaciones Cientificas | Procedimiento de obtencion de las cinatrinas c3 y c1. |
US20160184354A1 (en) | 2009-01-23 | 2016-06-30 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
JP2013249293A (ja) * | 2012-06-04 | 2013-12-12 | Kao Corp | リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3943165A (en) * | 1972-07-14 | 1976-03-09 | Lever Brothers Company | Esters of carboxymethyloxysuccinic acid and derivatives thereof |
US4145437A (en) * | 1975-08-21 | 1979-03-20 | Imperial Chemical Industries Limited | Hydroxy acids |
GB8401149D0 (en) * | 1984-01-17 | 1984-02-22 | Fujisawa Pharmaceutical Co | Furanone derivatives |
IT1213330B (it) * | 1986-08-28 | 1989-12-20 | Rol Spa | Tensioattivi derivati da idrossiacidi bi- o tri-carbossilici. |
DE3830068A1 (de) * | 1988-09-03 | 1990-04-05 | Hoechst Ag | Amidoamin-salze von alkenylbernsteinsaeurederivaten, verfahren zu deren herstellung und deren verwendung als korrosionsinhibitoren |
-
1990
- 1990-06-06 JP JP2148007A patent/JPH03108490A/ja active Pending
- 1990-06-22 DE DE69018529T patent/DE69018529T2/de not_active Expired - Fee Related
- 1990-06-22 AT AT90306872T patent/ATE121091T1/de active
- 1990-06-22 DK DK90306872.4T patent/DK0405864T3/da active
- 1990-06-22 EP EP90306872A patent/EP0405864B1/de not_active Expired - Lifetime
- 1990-06-22 ES ES90306872T patent/ES2073529T3/es not_active Expired - Lifetime
- 1990-06-27 US US07/544,673 patent/US5099034A/en not_active Expired - Fee Related
- 1990-06-30 KR KR1019900009839A patent/KR910001037A/ko not_active Application Discontinuation
- 1990-11-26 US US07/617,882 patent/US5120647A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH03108490A (ja) | 1991-05-08 |
US5099034A (en) | 1992-03-24 |
ATE121091T1 (de) | 1995-04-15 |
EP0405864A3 (en) | 1992-01-08 |
ES2073529T3 (es) | 1995-08-16 |
EP0405864B1 (de) | 1995-04-12 |
EP0405864A2 (de) | 1991-01-02 |
US5120647A (en) | 1992-06-09 |
DE69018529D1 (de) | 1995-05-18 |
KR910001037A (ko) | 1991-01-30 |
DK0405864T3 (da) | 1995-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |