ATE34176T1 - 2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung. - Google Patents
2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung.Info
- Publication number
- ATE34176T1 ATE34176T1 AT85301310T AT85301310T ATE34176T1 AT E34176 T1 ATE34176 T1 AT E34176T1 AT 85301310 T AT85301310 T AT 85301310T AT 85301310 T AT85301310 T AT 85301310T AT E34176 T1 ATE34176 T1 AT E34176T1
- Authority
- AT
- Austria
- Prior art keywords
- chloropentostatin
- compound
- microorganism
- production
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- JYWSHPMZFVPRRF-AMFMTJJISA-N (8r)-3-[(2r,3r,4r,5r)-3-chloro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4h-imidazo[4,5-d][1,3]diazepin-8-ol Chemical compound Cl[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 JYWSHPMZFVPRRF-AMFMTJJISA-N 0.000 title 1
- JYWSHPMZFVPRRF-UHFFFAOYSA-N 2'-chloropentostatin Natural products ClC1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 JYWSHPMZFVPRRF-UHFFFAOYSA-N 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 102000055025 Adenosine deaminases Human genes 0.000 abstract 1
- 241000450599 DNA viruses Species 0.000 abstract 1
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 238000010564 aerobic fermentation Methods 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940125782 compound 2 Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 241001446247 uncultured actinomycete Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59023984A | 1984-03-16 | 1984-03-16 | |
| EP85301310A EP0156524B1 (de) | 1984-03-16 | 1985-02-27 | 2'-Chloropentostatin, eine diese Verbindung enthaltende pharmazeutische Zusammensetzung und ein Mikroorganismus zur Herstellung dieser Verbindung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE34176T1 true ATE34176T1 (de) | 1988-05-15 |
Family
ID=24361432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85301310T ATE34176T1 (de) | 1984-03-16 | 1985-02-27 | 2'-chloropentostatin, eine diese verbindung enthaltende pharmazeutische zusammensetzung und ein mikroorganismus zur herstellung dieser verbindung. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0156524B1 (de) |
| JP (1) | JPH0613544B2 (de) |
| AT (1) | ATE34176T1 (de) |
| DE (1) | DE3562623D1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8911029D0 (en) * | 1989-05-13 | 1989-06-28 | Schering Agrochemicals Ltd | Herbicide |
| US5773607A (en) * | 1991-11-14 | 1998-06-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Processes for preparing 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof |
| KR0163799B1 (ko) * | 1991-11-14 | 1998-11-16 | 오메자와 준오 | 2'-데옥시-2'-플루오로코포르마이신과 이의 입체 이성체 |
| JPH09241294A (ja) * | 1996-03-07 | 1997-09-16 | Microbial Chem Res Found | ２′−デオキシ−２′−ハロコホルマイシン又はその立体異性体の製造法 |
| KR100408426B1 (ko) * | 2003-03-27 | 2003-12-03 | 파미셀주식회사 | 아데노신 디아미네이즈 저해제 및 이를 생산하는 신규한바실러스 아이에이디에이-7 균주 |
| CN113980860B (zh) * | 2021-11-23 | 2023-09-08 | 天津商业大学 | 一种高产喷司他丁和2’-氨基-2’-脱氧腺苷的野野村菌及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923785A (en) * | 1974-04-22 | 1975-12-02 | Parke Davis & Co | (R)-3-(2-deoxy-{62 -D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo{8 4,5-d{9 {8 1,3{9 diazepin-8-ol |
| JPS60992B2 (ja) * | 1977-03-15 | 1985-01-11 | 財団法人微生物化学研究会 | コホルマイシンおよび関連物質の分離法 |
-
1985
- 1985-02-27 EP EP85301310A patent/EP0156524B1/de not_active Expired
- 1985-02-27 DE DE8585301310T patent/DE3562623D1/de not_active Expired
- 1985-02-27 AT AT85301310T patent/ATE34176T1/de not_active IP Right Cessation
- 1985-03-15 JP JP60050662A patent/JPH0613544B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0156524B1 (de) | 1988-05-11 |
| DE3562623D1 (en) | 1988-06-16 |
| EP0156524A2 (de) | 1985-10-02 |
| JPH0613544B2 (ja) | 1994-02-23 |
| JPS60209598A (ja) | 1985-10-22 |
| EP0156524A3 (en) | 1986-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |