RU2002129890A - Перцихиннин, способ его получения и его применение в качестве фармацевтического средства - Google Patents
Перцихиннин, способ его получения и его применение в качестве фармацевтического средстваInfo
- Publication number
- RU2002129890A RU2002129890A RU2002129890/04A RU2002129890A RU2002129890A RU 2002129890 A RU2002129890 A RU 2002129890A RU 2002129890/04 A RU2002129890/04 A RU 2002129890/04A RU 2002129890 A RU2002129890 A RU 2002129890A RU 2002129890 A RU2002129890 A RU 2002129890A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- percyquinnin
- dsm
- derivative
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Virology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
Claims (7)
1. Перцихиннин, соединение формулы
и его фармацевтически приемлемые соли и производные во всех стереоизомерных и таутомерных формах.
2. Перцихиннин, соединение формулы С12Н16О3, которое может быть получено путем культивирования грибов ST 001837 (DSM 13303) в аэробных условиях в питательной среде, содержащей источники углерода и азота, с последующим его выделением и очисткой стандартным способом, и его фармацевтически приемлемые соли и производные во всех их стереоизомерных и таутомерных формах.
3. Способ получения перцихиннина или его соли или производного по п.1 или 2, предусматривающий культивирование базидиомицетов вида ST 001837 (DSM 13303) в аэробных условиях в питательной среде, содержащей источники углерода и азота с последующим его выделением и очисткой стандартным способом.
4. Базидиомицеты вида ST 001837 (DSM 13303).
5. Перцихиннин или его фармацевтически приемлемая соль или производное по п.1 или 2 для применения в качестве фармацевтического средства.
6. Фармацевтическая композиция, содержащая эффективное количество перцихиннина или его фармацевтически приемлемой соли или производного по п.1 или 2 и фармацевтически приемлемый носитель.
7. Перцихиннин или его фармацевтически приемлемая соль или производное по п.1 или 2 для применения в качестве ингибитора липазы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00107536.5 | 2000-04-07 | ||
| EP00107536A EP1142886A1 (en) | 2000-04-07 | 2000-04-07 | Percyquinnin, a process for its production and its use as a pharmaceutical |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002129890A true RU2002129890A (ru) | 2004-03-27 |
| RU2266290C2 RU2266290C2 (ru) | 2005-12-20 |
Family
ID=8168397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002129890/04A RU2266290C2 (ru) | 2000-04-07 | 2001-03-24 | Перцихиннин, способ его получения и его применение в качестве фармацевтического средства |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6596518B2 (ru) |
| EP (2) | EP1142886A1 (ru) |
| JP (1) | JP2003530391A (ru) |
| KR (1) | KR100791798B1 (ru) |
| CN (1) | CN1199959C (ru) |
| AT (1) | ATE269855T1 (ru) |
| AU (2) | AU784902B2 (ru) |
| BR (1) | BR0109854A (ru) |
| CA (1) | CA2405066A1 (ru) |
| CZ (1) | CZ20023310A3 (ru) |
| DE (1) | DE60103995T2 (ru) |
| DK (1) | DK1274698T3 (ru) |
| EE (1) | EE200200572A (ru) |
| ES (1) | ES2222992T3 (ru) |
| HK (1) | HK1052005A1 (ru) |
| HR (1) | HRP20020796A2 (ru) |
| HU (1) | HUP0300327A3 (ru) |
| IL (2) | IL152073A0 (ru) |
| MX (1) | MXPA02007895A (ru) |
| NO (1) | NO20024772L (ru) |
| NZ (1) | NZ521782A (ru) |
| PL (1) | PL357909A1 (ru) |
| PT (1) | PT1274698E (ru) |
| RS (1) | RS50140B (ru) |
| RU (1) | RU2266290C2 (ru) |
| SI (1) | SI1274698T1 (ru) |
| SK (1) | SK14322002A3 (ru) |
| TR (1) | TR200401739T4 (ru) |
| WO (1) | WO2001077094A1 (ru) |
| ZA (1) | ZA200207910B (ru) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1142886A1 (en) * | 2000-04-07 | 2001-10-10 | Aventis Pharma Deutschland GmbH | Percyquinnin, a process for its production and its use as a pharmaceutical |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| US7572783B2 (en) | 2004-08-13 | 2009-08-11 | Amgen Inc. | Substituted benzofused heterocycles |
| WO2007018248A1 (ja) | 2005-08-10 | 2007-02-15 | Banyu Pharmaceutical Co., Ltd. | ピリドン化合物 |
| EP1921065B1 (en) | 2005-08-24 | 2010-10-20 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| US20090264426A1 (en) | 2005-09-07 | 2009-10-22 | Shunji Sakuraba | Bicyclic aromatic substituted pyridone derivative |
| BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| CA2625416A1 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| JPWO2007049798A1 (ja) | 2005-10-27 | 2009-04-30 | 萬有製薬株式会社 | 新規ベンゾオキサチイン誘導体 |
| MY146564A (en) | 2005-11-10 | 2012-08-30 | Msd Kk | Aza-substituted spiro derivatives |
| CN100417650C (zh) * | 2006-08-17 | 2008-09-10 | 中国科学院昆明植物研究所 | 韧革菌素及其制备方法和在药物上的应用 |
| EP2946778A1 (en) | 2006-09-22 | 2015-11-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| AU2007301126A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| EP2264026A4 (en) | 2008-03-06 | 2012-03-28 | Msd Kk | ALKYLAMINOPYRIDINE DERIVATIVE |
| CA2717384A1 (en) | 2008-03-28 | 2009-10-01 | Banyu Pharmaceutical Co., Ltd. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
| AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2727914A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diaryl ketoxime derivative technical field |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2731358A1 (en) | 2008-07-30 | 2010-02-04 | Banyu Pharmaceutical Co., Ltd. | 5/5-or 5/6-membered condensed ring cycloalkylamine derivative |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| BRPI0919876A8 (pt) | 2008-10-30 | 2016-02-10 | Merck Sharp & Dohme | Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo. |
| JP5557845B2 (ja) | 2008-10-31 | 2014-07-23 | メルク・シャープ・アンド・ドーム・コーポレーション | 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体 |
| EP2538784B1 (en) | 2010-02-25 | 2015-09-09 | Merck Sharp & Dohme Corp. | Benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP2677869B1 (en) | 2011-02-25 | 2017-11-08 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| CA2898482A1 (en) | 2013-02-22 | 2014-08-28 | Linda L. Brockunier | Antidiabetic bicyclic compounds |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| CN105906500B (zh) * | 2016-04-22 | 2018-06-26 | 中国科学院昆明植物研究所 | 具有脂肪酶抑制作用的绵马次酸类化合物及其应用 |
| MX2019004321A (es) | 2016-10-14 | 2019-06-12 | Tes Pharma S R L | Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa. |
| EP3551176A4 (en) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | ANTIDIABETIC HETEROCYCLIC COMPOUNDS |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| CN109055231B (zh) * | 2018-07-26 | 2021-04-27 | 云南大学 | 一种真菌发酵液及其应用 |
| JP2022507805A (ja) | 2018-11-20 | 2022-01-18 | ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ | α－アミノ－β－カルボキシムコン酸セミアルデヒドデカルボキシラーゼ阻害剤 |
| EP3924058A1 (en) | 2019-02-13 | 2021-12-22 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| EP4010314B1 (en) | 2019-08-08 | 2024-02-28 | Merck Sharp & Dohme LLC | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| KR20230053639A (ko) | 2020-08-18 | 2023-04-21 | 머크 샤프 앤드 돔 엘엘씨 | 비시클로헵탄 피롤리딘 오렉신 수용체 효능제 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2344285A1 (fr) * | 1976-03-19 | 1977-10-14 | Roussel Uclaf | Nouvelles lactones derivees du cyclopentanol, leur procede de preparation et leur application comme medicaments |
| US5322779A (en) * | 1992-04-16 | 1994-06-21 | The Research And Development Institute, Inc. At Montana State University | Taxol production by taxomyces andreanae |
| EP1142886A1 (en) * | 2000-04-07 | 2001-10-10 | Aventis Pharma Deutschland GmbH | Percyquinnin, a process for its production and its use as a pharmaceutical |
-
2000
- 2000-04-07 EP EP00107536A patent/EP1142886A1/en not_active Withdrawn
-
2001
- 2001-03-24 CZ CZ20023310A patent/CZ20023310A3/cs unknown
- 2001-03-24 CN CNB018064981A patent/CN1199959C/zh not_active Expired - Fee Related
- 2001-03-24 MX MXPA02007895A patent/MXPA02007895A/es active IP Right Grant
- 2001-03-24 JP JP2001575568A patent/JP2003530391A/ja active Pending
- 2001-03-24 AU AU56219/01A patent/AU784902B2/en not_active Ceased
- 2001-03-24 EE EEP200200572A patent/EE200200572A/xx unknown
- 2001-03-24 AT AT01929453T patent/ATE269855T1/de not_active IP Right Cessation
- 2001-03-24 PL PL01357909A patent/PL357909A1/xx not_active IP Right Cessation
- 2001-03-24 DE DE60103995T patent/DE60103995T2/de not_active Expired - Lifetime
- 2001-03-24 SK SK1432-2002A patent/SK14322002A3/sk unknown
- 2001-03-24 RU RU2002129890/04A patent/RU2266290C2/ru not_active IP Right Cessation
- 2001-03-24 HU HU0300327A patent/HUP0300327A3/hu unknown
- 2001-03-24 NZ NZ521782A patent/NZ521782A/en unknown
- 2001-03-24 WO PCT/EP2001/003392 patent/WO2001077094A1/en active IP Right Grant
- 2001-03-24 KR KR1020027013443A patent/KR100791798B1/ko not_active IP Right Cessation
- 2001-03-24 CA CA002405066A patent/CA2405066A1/en not_active Abandoned
- 2001-03-24 DK DK01929453T patent/DK1274698T3/da active
- 2001-03-24 SI SI200130168T patent/SI1274698T1/xx unknown
- 2001-03-24 IL IL15207301A patent/IL152073A0/xx active IP Right Grant
- 2001-03-24 TR TR2004/01739T patent/TR200401739T4/xx unknown
- 2001-03-24 RS YUP-740/02A patent/RS50140B/sr unknown
- 2001-03-24 BR BR0109854-3A patent/BR0109854A/pt not_active Application Discontinuation
- 2001-03-24 PT PT01929453T patent/PT1274698E/pt unknown
- 2001-03-24 EP EP01929453A patent/EP1274698B1/en not_active Expired - Lifetime
- 2001-03-24 ES ES01929453T patent/ES2222992T3/es not_active Expired - Lifetime
- 2001-04-06 US US09/826,866 patent/US6596518B2/en not_active Expired - Lifetime
-
2002
- 2002-10-02 ZA ZA200207910A patent/ZA200207910B/en unknown
- 2002-10-02 IL IL152073A patent/IL152073A/en not_active IP Right Cessation
- 2002-10-03 NO NO20024772A patent/NO20024772L/no not_active Application Discontinuation
- 2002-10-04 HR HRP20020796 patent/HRP20020796A2/hr not_active Application Discontinuation
-
2003
- 2003-06-12 HK HK03104187A patent/HK1052005A1/xx not_active IP Right Cessation
-
2006
- 2006-08-25 AU AU2006203704A patent/AU2006203704B8/en not_active Ceased
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