GB1508977A - Beta-lactam antibiotic from streptomyces clavuligerus - Google Patents

Beta-lactam antibiotic from streptomyces clavuligerus

Info

Publication number
GB1508977A
GB1508977A GB17410/74A GB1741074A GB1508977A GB 1508977 A GB1508977 A GB 1508977A GB 17410/74 A GB17410/74 A GB 17410/74A GB 1741074 A GB1741074 A GB 1741074A GB 1508977 A GB1508977 A GB 1508977A
Authority
GB
United Kingdom
Prior art keywords
acid
cephaloglycine
benzylpenicillin
ticarcillin
carbenicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17410/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB17410/74A priority Critical patent/GB1508977A/en
Priority to IE792/75A priority patent/IE41109B1/en
Priority to IE1987/78A priority patent/IE41110B1/en
Priority to NZ177159A priority patent/NZ177159A/en
Priority to YU908/75A priority patent/YU39941B/en
Priority to FR7511344A priority patent/FR2267778B1/fr
Priority to CY1078A priority patent/CY1078A/en
Priority to IL47087A priority patent/IL47087A/en
Priority to BE155402A priority patent/BE827926A/en
Priority to IN743/CAL/75A priority patent/IN140042B/en
Priority to AU80177/75A priority patent/AU499171B2/en
Priority to FI751133A priority patent/FI54144C/en
Priority to AR258435A priority patent/AR206627A1/en
Priority to MX513175U priority patent/MX3973E/en
Priority to MX513075U priority patent/MX4009E/en
Priority to DE2559411A priority patent/DE2559411C2/en
Priority to AT298575A priority patent/AT352270B/en
Priority to LU72322A priority patent/LU72322A1/xx
Priority to SE7504541A priority patent/SE422063B/en
Priority to NO751407A priority patent/NO145247C/en
Priority to SU752129801A priority patent/SU648117A3/en
Priority to DE19752559410 priority patent/DE2559410A1/en
Priority to NL7504621.A priority patent/NL163824C/en
Priority to CA224,970A priority patent/CA1059050A/en
Priority to DD185542A priority patent/DD121799A5/xx
Priority to DK167275AA priority patent/DK141254B/en
Priority to HU75BE1267A priority patent/HU173700B/en
Priority to DE2517316A priority patent/DE2517316C2/en
Priority to DD7500193531A priority patent/DD132297A5/en
Priority to CS752721A priority patent/CS231157B2/en
Priority to DE2560074A priority patent/DE2560074C2/en
Priority to ZA00752492A priority patent/ZA752492B/en
Priority to ES436766A priority patent/ES436766A1/en
Priority to RO7582037A priority patent/RO69984A/en
Priority to RO7595311A priority patent/RO77320A/en
Priority to OA55480A priority patent/OA05203A/en
Priority to JP50048086A priority patent/JPS521996B2/ja
Priority to EG33575A priority patent/EG12445A/en
Priority to JP50048087A priority patent/JPS5246957B2/ja
Priority to CH506075A priority patent/CH629252A5/en
Priority to PH17082A priority patent/PH16474A/en
Priority to AR261403A priority patent/AR216430A1/en
Priority to AR261404A priority patent/AR219050A1/en
Priority to US05/726,061 priority patent/US4110165A/en
Priority to US06/726,224 priority patent/US4427690A/en
Priority to JP16090276A priority patent/JPS5285189A/en
Priority to AT205277A priority patent/AT350718B/en
Priority to AT205377A priority patent/AT353407B/en
Priority to AT205577A priority patent/AT348124B/en
Priority to AT205477A priority patent/AT350719B/en
Priority to JP4025877A priority patent/JPS532495A/en
Priority to JP4025777A priority patent/JPS532494A/en
Priority to JP4026077A priority patent/JPS533589A/en
Priority to JP4025977A priority patent/JPS533588A/en
Priority to JP4026177A priority patent/JPS533590A/en
Priority to FI780202A priority patent/FI780202A/en
Priority to FI780201A priority patent/FI58332C/en
Publication of GB1508977A publication Critical patent/GB1508977A/en
Priority to DK287378A priority patent/DK150489C/en
Priority to DK287078A priority patent/DK145543C/en
Priority to DK287278A priority patent/DK150488C/en
Priority to DK287178A priority patent/DK287178A/en
Priority to US05/924,174 priority patent/US4556559A/en
Priority to SE7811202A priority patent/SE435287B/en
Priority to SE7811203A priority patent/SE443562B/en
Priority to SE7811200A priority patent/SE435286B/en
Priority to SE7811201A priority patent/SE446687B/en
Priority to CA314,880A priority patent/CA1055395A/en
Priority to CA314,882A priority patent/CA1076120A/en
Priority to CA314,881A priority patent/CA1074325A/en
Priority to NO791956A priority patent/NO150838C/en
Priority to NO801852A priority patent/NO801852L/en
Priority to DK286980A priority patent/DK157302C/en
Priority to KE3076A priority patent/KE3076A/en
Priority to HK547/80A priority patent/HK54780A/en
Priority to CH947280A priority patent/CH630631A5/en
Priority to US06/272,030 priority patent/US4526783A/en
Priority to US06/305,337 priority patent/US4529720A/en
Priority to SE8105829A priority patent/SE453600B/en
Priority to YU2743/81A priority patent/YU42744B/en
Priority to YU2744/81A priority patent/YU42745B/en
Priority to US06/327,253 priority patent/US4525352A/en
Priority to US06330456 priority patent/US4560552C1/en
Priority to MY195/81A priority patent/MY8100195A/en
Priority to US06/352,951 priority patent/US4525353A/en
Priority to SE8306328A priority patent/SE8306328D0/en
Priority to SE8605405A priority patent/SE8605405D0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1508977 Antibiotic compositions containing clavulanic add BEECHAM GROUP Ltd 11 April 1975 17410/74 27715/74 43651/74 and 53525/74 Heading A5B [Also in Division C2] Pharmaceutical compositions having antibacterial activity comprise, as active ingredient clavulanic acid of the formula or a pharceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier and optionally other therapeutically active agents such as #-lactam antibiotics, e.g. benzylpenicillin, phenoxymethylpenicillin, carbenicillin, methicillin, propioillin, ampicillin, amoxycillin, epicillin, ticarcillin, cyclacillin, 6- aminopenicillanic acid, 7 - aminocephalosporanic acid, 7 - aminodesacetoxycephalosporanic acid, cephaloridine, cephalothin, cephazolin, cephalexin, cefoxitin, cephacetrile, cephamandole, cephapirin, cephradine, cephaloglycine, hetaoillin, metampicillin, the acetoxymethyl, pivaloyloxymethyl or phthalidyl esters of benzylpenicillin, ampicillin, amoxyoillin or cephaloglycine or the phenyl, tolyl or indanyl α-esters of carbenicillin or ticarcillin. They may be administered orally, topically or parenterally e.g. as tablets, capsules, creams, syrups, suspensions, solutions, reconstitutable powders and sterile forms suitable for injection or infusion.
GB17410/74A 1973-05-04 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus Expired GB1508977A (en)

Priority Applications (86)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
IE792/75A IE41109B1 (en) 1974-04-20 1975-04-08 Novel -lactam antibiotic from streptomyces clavuligerus
IE1987/78A IE41110B1 (en) 1974-04-20 1975-04-08 Esters of clavulanic acid
NZ177159A NZ177159A (en) 1974-04-20 1975-04-08 Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
YU908/75A YU39941B (en) 1974-04-20 1975-04-09 Process for obtaining clavulanic acid
FR7511344A FR2267778B1 (en) 1974-04-20 1975-04-11
CY1078A CY1078A (en) 1974-04-20 1975-04-11 Beta-lactam antibiotic from strepomyces clavuligerus
IL47087A IL47087A (en) 1974-04-20 1975-04-14 Antibiotic compounds obtained from streptomyces clavuligerus their preparation and pharmaceutical compositions containig them
BE155402A BE827926A (en) 1974-04-20 1975-04-14 ANTIBIOTIC
IN743/CAL/75A IN140042B (en) 1974-04-20 1975-04-14
AU80177/75A AU499171B2 (en) 1973-05-04 1975-04-15 Clavulanic acid derivatives
FI751133A FI54144C (en) 1974-04-20 1975-04-16 FOERFARANDE FOER FRAMSTAELLNING AV KLAVULANSYRA ELLER ETT SALT DAERAV
AR258435A AR206627A1 (en) 1974-04-20 1975-04-18 PROCEDURE FOR THE PREPARATION OF CALVULANIC ACID
MX513175U MX3973E (en) 1974-04-20 1975-04-18 PROCEDURE FOR THE PREPARATION OF CLAVULANIC ACID ESTERS
MX513075U MX4009E (en) 1974-04-20 1975-04-18 PROCEDURE FOR THE PREPARATION OF CLAVANIC ACID ESTERS
DE2559411A DE2559411C2 (en) 1974-04-20 1975-04-18 Use of clavulanic acid
AT298575A AT352270B (en) 1974-04-20 1975-04-18 METHOD FOR PRODUCING THE NEW CLAVULANIC ACIDS
LU72322A LU72322A1 (en) 1974-04-20 1975-04-18
SE7504541A SE422063B (en) 1974-04-20 1975-04-18 PROCEDURE FOR PREPARING ANIBIOTICS FROM S.CLOVULIGERUS
NO751407A NO145247C (en) 1974-04-20 1975-04-18 PROCEDURE FOR THE PREPARATION OF CLAVULANIC ACID
SU752129801A SU648117A3 (en) 1974-04-20 1975-04-18 Method of obtaining antibacterial substance
DE19752559410 DE2559410A1 (en) 1974-04-20 1975-04-18 ESTERS OF CLAVULANIC ACIDS, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
NL7504621.A NL163824C (en) 1974-04-20 1975-04-18 PROCESS FOR THE RECOVERY OF AN ANTIBIOTIC WITH AN EFFICIENCY AGAINST BACTERIA CALLED CLAVULANIC ACID, PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS CONTAINING THIS ANTIBIOTIC PRODUCT OR A SALT OR ESTER PREPARED THEREFORE, INCLUDING PREPARATIONS
CA224,970A CA1059050A (en) 1974-04-20 1975-04-18 Clavulanic acid from streptomyces clavuligerus
DD185542A DD121799A5 (en) 1974-04-20 1975-04-18
DK167275AA DK141254B (en) 1974-04-20 1975-04-18 Process for preparing clavulanic acid or a salt or ester thereof.
HU75BE1267A HU173700B (en) 1974-04-20 1975-04-18 Process for producing esters of clavulanic acid
DE2517316A DE2517316C2 (en) 1974-04-20 1975-04-18 Clavulanic acid and its salts and medicinal products containing these compounds
DD7500193531A DD132297A5 (en) 1974-04-20 1975-04-18 METHOD FOR PRODUCING A SYNERGISTIC PHARMACEUTICAL AGENT
CS752721A CS231157B2 (en) 1974-04-20 1975-04-18 Processing method of klavulan acid and corresponding salts and esters
DE2560074A DE2560074C2 (en) 1974-04-20 1975-04-18 Process for the production of clavulanic acid and its salts
ZA00752492A ZA752492B (en) 1974-04-20 1975-04-18 Antibiotics
ES436766A ES436766A1 (en) 1974-04-20 1975-04-18 A procedure for the preparation of a clavulan acid salt. (Machine-translation by Google Translate, not legally binding)
RO7582037A RO69984A (en) 1974-04-20 1975-04-19 CLAVULIAN ACID PROCESSING PROCEDURE
RO7595311A RO77320A (en) 1974-04-20 1975-04-19 PROCEDURE FOR THE PURIFICATION OF CLAVULANIC ACID SALTS
OA55480A OA05203A (en) 1974-04-20 1975-04-19 New Antibiotics.
JP50048086A JPS521996B2 (en) 1974-04-20 1975-04-19
EG33575A EG12445A (en) 1974-04-20 1975-04-19 Process for preparing of antibiotics
JP50048087A JPS5246957B2 (en) 1974-04-20 1975-04-19
CH506075A CH629252A5 (en) 1974-04-20 1975-04-21 METHOD FOR THE PRODUCTION OF CLAVULANIC ACID AND ITS SALTS.
PH17082A PH16474A (en) 1974-04-20 1975-04-21 Clavulcanic acid,salts and esters thereof and pharmaceutical compositions containing same
AR261403A AR216430A1 (en) 1974-04-20 1975-11-28 A PROCEDURE FOR THE PREPARATION OF CLAVULANIC ACID ESTERS
AR261404A AR219050A1 (en) 1974-04-20 1975-11-28 PROCEDURE FOR THE PREPARATION OF ESTERS OF THE CLAVULANIC ACID
US05/726,061 US4110165A (en) 1974-04-20 1976-09-24 Process for the production of clavulanic acid
US06/726,224 US4427690A (en) 1974-04-20 1976-09-24 Esters of clavulanic acid
JP16090276A JPS5285189A (en) 1974-04-20 1976-12-28 Process for preparing antibiotics
AT205277A AT350718B (en) 1974-04-20 1977-03-24 PROCESS FOR THE PRODUCTION OF NEW CLAVULAN ACID ESTERS
AT205377A AT353407B (en) 1974-04-20 1977-03-24 METHOD FOR PREPARING SYNERGISTIC ANTIBACTERIAL COMPOSITIONS
AT205577A AT348124B (en) 1974-04-20 1977-03-24 PROCESS FOR THE PRODUCTION OF NEW CLAVULAN ACID SALT
AT205477A AT350719B (en) 1974-04-20 1977-03-24 PROCESS FOR THE PRODUCTION OF NEW SALT OF CLAVULANIC ACID
JP4025877A JPS532495A (en) 1974-04-20 1977-04-05 Method of purifying antibiotics
JP4025777A JPS532494A (en) 1974-04-20 1977-04-05 Process for preparing antibiotics
JP4026077A JPS533589A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025977A JPS533588A (en) 1974-04-20 1977-04-05 Production of antibiotic
JP4026177A JPS533590A (en) 1974-04-20 1977-04-05 Purification of antibiotic
FI780202A FI780202A (en) 1974-04-20 1978-01-23 FOERFARANDE FOER FRAMSTAELLNING AV ETT HUVUDSAKLIGEN RENT SALT AV KLAVULANCY
FI780201A FI58332C (en) 1974-04-20 1978-01-23 FOERFARANDE FOER FRAMSTAELLNING AV ESTRAR AV KLAVULANSYRA
DK287378A DK150489C (en) 1974-04-20 1978-06-26 PROCEDURE FOR PREPARING A CLAVULANIC ACID SAL
DK287078A DK145543C (en) 1974-04-20 1978-06-26 PROCEDURE FOR THE PREPARATION OF HYDRAULIZABLE ESTERS OF CLAVULANIC ACID
DK287278A DK150488C (en) 1974-04-20 1978-06-26 PROCEDURE FOR INSULATING A CLAVULANIC ACID SAL
DK287178A DK287178A (en) 1974-04-20 1978-06-26 PROCEDURE FOR PREPARING AN ANTIBIOTIC
US05/924,174 US4556559A (en) 1974-04-20 1978-07-13 Antibiotics
SE7811202A SE435287B (en) 1974-04-20 1978-10-27 ANALOGY PROCEDURE FOR THE PREPARATION OF CLAVULANIC ACID ESTERS
SE7811203A SE443562B (en) 1974-04-20 1978-10-27 PROCEDURE FOR PREPARING A PURE SALT OF CLAVULANIC ACID
SE7811200A SE435286B (en) 1974-04-20 1978-10-27 CLAVULANIC ACID FOR USE AS A CHEMICAL INTERMEDIATE IN THE PRODUCTION OF CLAVULANIC ACID DERIVATIVES
SE7811201A SE446687B (en) 1974-04-20 1978-10-27 PROCEDURE FOR PREPARING AN ANTIBACTERIAL, PHARMACEUTICAL PREPARATION WITH SYNERGISTIC EFFECT, INCLUDING CLAVULANIC ACID
CA314,880A CA1055395A (en) 1974-04-20 1978-10-30 Antibiotics
CA314,882A CA1076120A (en) 1974-04-20 1978-10-30 Clavulanic acid esters
CA314,881A CA1074325A (en) 1974-04-20 1978-10-30 Clavulanic acid and its salts
NO791956A NO150838C (en) 1974-04-20 1979-06-12 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW CLAVULANIC ACID COMPOUNDS WITH ANTIBACTERIAL AND BETA-LACTAMASE INHIBITIVE PROPERTIES
NO801852A NO801852L (en) 1974-04-20 1980-06-20 PHARMACEUTICAL CLAVULANIC ACID.
DK286980A DK157302C (en) 1974-04-20 1980-07-02 ESTERS OF CLAVULANIC ACID USED AS INTERMEDIATES IN THE PRODUCTION OF CLAVULANIC ACID OR PHARMACEUTICAL TOLERABLE SALTS THEREOF
KE3076A KE3076A (en) 1974-04-20 1980-08-29 Novel b-lactam antibiotic from streptomyces clavuligerus
HK547/80A HK54780A (en) 1974-04-20 1980-09-25 Novel b-lactam antibiotic from streptomyces clavuligerus
CH947280A CH630631A5 (en) 1974-04-20 1980-12-22 METHOD FOR PRODUCING CLAVULANIC ACID ESTERS AND THE USE THEREOF FOR PRODUCING CLAVULANIC ACID AND ITS SALTS.
US06/272,030 US4526783A (en) 1974-04-20 1981-06-09 Antibiotic from S. clavuligerus
US06/305,337 US4529720A (en) 1974-04-20 1981-09-24 Antibiotic from Streptomyces clavulicerus
SE8105829A SE453600B (en) 1974-04-20 1981-10-02 PROCEDURE FOR PREPARING A SALT OF CLAVULANIC ACID
YU2743/81A YU42744B (en) 1974-04-20 1981-11-23 Process for obtaining clavulinic acid esthers
YU2744/81A YU42745B (en) 1974-04-20 1981-11-23 Process for obtaining clavulinic acid esthers
US06/327,253 US4525352A (en) 1974-04-20 1981-12-03 Antibiotics
US06330456 US4560552C1 (en) 1974-04-20 1981-12-14 Antibiotics
MY195/81A MY8100195A (en) 1974-04-20 1981-12-30 Novel b-lactam antibiotic from streptomyes clavuligerus
US06/352,951 US4525353A (en) 1974-04-20 1982-02-26 Antibiotics
SE8306328A SE8306328D0 (en) 1974-04-20 1983-11-16 ESTARS OF CLAVULANIC ACID
SE8605405A SE8605405D0 (en) 1974-04-20 1986-12-16 PROCEDURE FOR PREPARING A SALT OF CLAVULANIC ACID

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus

Publications (1)

Publication Number Publication Date
GB1508977A true GB1508977A (en) 1978-04-26

Family

ID=10094711

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17410/74A Expired GB1508977A (en) 1973-05-04 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus

Country Status (6)

Country Link
AT (1) AT352270B (en)
BE (1) BE827926A (en)
CS (1) CS231157B2 (en)
GB (1) GB1508977A (en)
SU (1) SU648117A3 (en)
ZA (1) ZA752492B (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008525A2 (en) * 1978-08-25 1980-03-05 Beecham Group Plc Pharmaceutical compositions and process for their preparation
JPS5559108A (en) * 1978-10-27 1980-05-02 Beecham Group Ltd Mammary gland composition
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB2200355A (en) * 1987-01-29 1988-08-03 Beecham Group Plc Potassium clavulanate
EP0182522B1 (en) * 1984-10-27 1991-06-19 Beecham Group p.l.c. Preparation of clavulanic acid and its salts and esters
US5288861A (en) * 1987-01-29 1994-02-22 Beecham Group Plc Potassium clavulanate in rosette form
EP0594099A1 (en) * 1992-10-21 1994-04-27 Pharma Development Ltd. Process for the purification of crude clavulanic acid
EP0672669A1 (en) 1992-06-11 1995-09-20 Smithkline Beecham Plc Process for the preparation of clavulanic acid
US5498788A (en) * 1992-07-08 1996-03-12 Lek, Tovarna Farmacevtskih Inclusion complexes of clavulanic acid and of potassium salts thereof with hydrophobic β-cyclodextrin derivatives a process for the preparation thereof
WO1996018743A1 (en) * 1994-12-10 1996-06-20 Smithkline Beecham Plc Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
WO1996028452A1 (en) 1995-03-10 1996-09-19 Lek Pharmaceutical And Chemical Co. D.D. Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
JPH08511010A (en) * 1993-06-07 1996-11-19 バイエル・アクチエンゲゼルシヤフト Cyclobutylazole
WO1997008175A1 (en) * 1995-08-28 1997-03-06 Lek Pharmaceutical & Chemical Co. Dd Isolation of clavulanic acid from fermentation broth by ultrafiltration
EP0761218A1 (en) 1994-04-23 1997-03-12 Smithkline Beecham Corporation Process for preparing polymer coated tablet comprising amoxycillin and clavunalate
WO1997019187A1 (en) * 1995-11-23 1997-05-29 Antibioticos, S.A. Process for the production of clavulanic acid and/or salts thereof
US5726170A (en) * 1995-02-25 1998-03-10 Spurcourt Limited Clavulanic acid salts
US5734048A (en) * 1995-05-16 1998-03-31 Chong Kun Dang Corp. Process for manufacturing clavulanic acid salt
US5750685A (en) * 1987-01-29 1998-05-12 Smithkline Beecham, P.L.C. Process for preparing potassium clavulanate in rossette form
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ZA752492B (en) 1976-06-30
ATA298575A (en) 1979-02-15
CS231157B2 (en) 1984-10-15
AT352270B (en) 1979-09-10
CS272175A2 (en) 1984-02-13
BE827926A (en) 1975-10-14
SU648117A3 (en) 1979-02-15

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PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
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Effective date: 19950410