FR2688506B1 - Procede de preparation de sels de l'acide clavulanique. - Google Patents

Procede de preparation de sels de l'acide clavulanique.

Info

Publication number
FR2688506B1
FR2688506B1 FR9302720A FR9302720A FR2688506B1 FR 2688506 B1 FR2688506 B1 FR 2688506B1 FR 9302720 A FR9302720 A FR 9302720A FR 9302720 A FR9302720 A FR 9302720A FR 2688506 B1 FR2688506 B1 FR 2688506B1
Authority
FR
France
Prior art keywords
salts
preparation
clavulanic acid
clavulanic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9302720A
Other languages
English (en)
Other versions
FR2688506A1 (fr
Inventor
Krenmuller Franz
Summer Harald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of FR2688506A1 publication Critical patent/FR2688506A1/fr
Application granted granted Critical
Publication of FR2688506B1 publication Critical patent/FR2688506B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
FR9302720A 1992-03-10 1993-03-09 Procede de preparation de sels de l'acide clavulanique. Expired - Fee Related FR2688506B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (2)

Publication Number Publication Date
FR2688506A1 FR2688506A1 (fr) 1993-09-17
FR2688506B1 true FR2688506B1 (fr) 1995-06-23

Family

ID=3491521

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9302720A Expired - Fee Related FR2688506B1 (fr) 1992-03-10 1993-03-09 Procede de preparation de sels de l'acide clavulanique.

Country Status (21)

Country Link
US (4) US20010036940A1 (fr)
JP (2) JP2817563B2 (fr)
CN (3) CN1045604C (fr)
AT (1) AT400033B (fr)
AU (1) AU659282B2 (fr)
CH (1) CH685054A5 (fr)
CY (1) CY1995A (fr)
DE (1) DE4307422B4 (fr)
DK (1) DK26093A (fr)
ES (1) ES2058029B1 (fr)
FI (1) FI101965B1 (fr)
FR (1) FR2688506B1 (fr)
GB (1) GB2264944B (fr)
GR (1) GR1002329B (fr)
HK (1) HK42696A (fr)
IE (1) IE70926B1 (fr)
IT (1) IT1261213B (fr)
NL (1) NL9300430A (fr)
NO (1) NO301372B1 (fr)
SE (1) SE508043C2 (fr)
TW (1) TW364907B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
ATE198892T1 (de) 1993-11-17 2001-02-15 Biochemie Gmbh Trennung von cephalosporinisomeren
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (fr) * 1995-02-25 2001-12-19 Spurcourt Limited Sel de l'acide clavulanique
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP1095046A1 (fr) * 1998-07-16 2001-05-02 Dsm N.V. Procede ameliore de preparation de sels et d'esters d'acide clavulanique
CA2364342C (fr) * 1999-04-01 2011-02-01 Dsm N.V. Agglomerats obtenus par cristallisation
WO2001087891A1 (fr) * 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Procede de purification d'un sel d'acide clavulanique
CA2621982C (fr) * 2005-09-07 2017-11-28 Jennerex Biotherapeutics Ulc Traitement systemique de cancers metastasiques et/ou systemiquement dissemines a l'aide de poxvirus exprimant le gm-csf
JP7028064B2 (ja) 2018-05-30 2022-03-02 横河電機株式会社 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
WO2022008876A1 (fr) 2020-07-10 2022-01-13 Carbon Clean Solutions Limited Procédé et système pour l'élimination de dioxyde de carbone de solvants à l'aide de chaleur à basse température

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288800A (en) 1962-05-29 1966-11-29 Squibb & Sons Inc Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1561395A (en) 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
EP0002312B1 (fr) 1977-11-26 1982-02-03 Beecham Group Plc Dérivés de l'acide clavulanique et compositions pharmaceutiques les contenant
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
EP0026044B1 (fr) * 1979-08-24 1983-06-08 Beecham Group Plc Sel amine de l'acide clavulanique, sa préparation et son utilisation
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
AU600655B2 (en) 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8618888D0 (en) 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
NZ223316A (en) 1987-01-29 1989-10-27 Beecham Group Plc Crystalline potassium clavulanate and pharmaceutical compositions
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB2298201B (en) 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (fr) 1995-02-25 2001-12-19 Spurcourt Limited Sel de l'acide clavulanique
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
ES2058029A1 (es) 1994-10-16
CN1145906A (zh) 1997-03-26
IE930172A1 (en) 1993-09-22
FI931032A (fi) 1993-09-11
CN1150153A (zh) 1997-05-21
DK26093A (da) 1993-09-11
ITRM930147A1 (it) 1994-09-10
DK26093D0 (da) 1993-03-09
DE4307422B4 (de) 2004-11-25
AU659282B2 (en) 1995-05-11
US20030203886A1 (en) 2003-10-30
FR2688506A1 (fr) 1993-09-17
TW364907B (en) 1999-07-21
JPH0641143A (ja) 1994-02-15
SE508043C2 (sv) 1998-08-17
NO930829D0 (no) 1993-03-08
USH2158H1 (en) 2006-06-06
NO301372B1 (no) 1997-10-20
AT400033B (de) 1995-09-25
SE9300758D0 (sv) 1993-03-08
AU3407093A (en) 1993-09-16
GB9304704D0 (en) 1993-04-28
ES2058029B1 (es) 1995-05-01
HK42696A (en) 1996-03-22
NO930829L (no) 1993-09-13
DE4307422A1 (de) 1993-09-30
JP2817563B2 (ja) 1998-10-30
US20020072513A1 (en) 2002-06-13
FI931032A0 (fi) 1993-03-09
CN1045604C (zh) 1999-10-13
IT1261213B (it) 1996-05-09
FI101965B (fi) 1998-09-30
GR1002329B (el) 1996-05-15
ITRM930147A0 (it) 1993-03-10
US20030022882A1 (en) 2003-01-30
ATA47292A (de) 1995-01-15
IE70926B1 (en) 1997-01-15
FI101965B1 (fi) 1998-09-30
US20010036940A1 (en) 2001-11-01
SE9300758L (sv) 1993-09-11
CY1995A (en) 1997-09-05
NL9300430A (nl) 1993-10-01
GB2264944A (en) 1993-09-15
CH685054A5 (de) 1995-03-15
GB2264944B (en) 1995-09-06
GR930100090A (el) 1993-11-30
JPH1067785A (ja) 1998-03-10
CN1079743A (zh) 1993-12-22

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Legal Events

Date Code Title Description
CD Change of name or company name
TP Transmission of property
ST Notification of lapse

Effective date: 20091130