FR2583419B1 - Procede pour la preparation de 2-bromo-a-ergocryptine et ses sels d'addition d'acides. - Google Patents

Procede pour la preparation de 2-bromo-a-ergocryptine et ses sels d'addition d'acides.

Info

Publication number
FR2583419B1
FR2583419B1 FR868608487A FR8608487A FR2583419B1 FR 2583419 B1 FR2583419 B1 FR 2583419B1 FR 868608487 A FR868608487 A FR 868608487A FR 8608487 A FR8608487 A FR 8608487A FR 2583419 B1 FR2583419 B1 FR 2583419B1
Authority
FR
France
Prior art keywords
ergocryptine
bromo
acids
preparation
added salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR868608487A
Other languages
English (en)
Other versions
FR2583419A1 (fr
Inventor
Gabor Megyeri
Tibor Keve
Janos Galambos
Lajos Kovacs Jr
Bela Stefko
Erik Bogsch
Ferenc Trischler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2583419A1 publication Critical patent/FR2583419A1/fr
Application granted granted Critical
Publication of FR2583419B1 publication Critical patent/FR2583419B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR868608487A 1985-06-12 1986-06-12 Procede pour la preparation de 2-bromo-a-ergocryptine et ses sels d'addition d'acides. Expired - Fee Related FR2583419B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU852300A HU193317B (en) 1985-06-12 1985-06-12 Process for producing 2-bromo-alpha-ergochristin

Publications (2)

Publication Number Publication Date
FR2583419A1 FR2583419A1 (fr) 1986-12-19
FR2583419B1 true FR2583419B1 (fr) 1990-01-12

Family

ID=10958743

Family Applications (1)

Application Number Title Priority Date Filing Date
FR868608487A Expired - Fee Related FR2583419B1 (fr) 1985-06-12 1986-06-12 Procede pour la preparation de 2-bromo-a-ergocryptine et ses sels d'addition d'acides.

Country Status (13)

Country Link
US (1) US4697017A (fr)
JP (1) JPS61286390A (fr)
BE (1) BE904897A (fr)
CA (1) CA1256103A (fr)
CH (1) CH667092A5 (fr)
CS (1) CS262670B2 (fr)
DE (1) DE3619617A1 (fr)
ES (1) ES8707236A1 (fr)
FR (1) FR2583419B1 (fr)
GB (1) GB2176479B (fr)
HU (1) HU193317B (fr)
IT (1) IT1191806B (fr)
YU (1) YU100886A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives
GB9218242D0 (en) * 1992-08-27 1992-10-14 Ici Plc Chemical process
CA2219978C (fr) * 1995-06-07 2011-02-01 Ergo Science Incorporated Procede d'inhibition de maladies neoplasiques chez les mammiferes
CN103073387A (zh) * 2013-02-08 2013-05-01 天津师范大学 一种9，10-二溴蒽的制备方法
CN105646547B (zh) * 2014-12-03 2019-05-17 四川海思科制药有限公司 一种甲磺酸溴隐亭化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
CH573431A5 (en) * 1972-06-13 1976-03-15 Sandoz Ag Dibromo-dihydro-lysergic acid prepn. - by bromination of 9,10-dihydro-lysergic acid in inert solvent, pref. glacial alcoholic or propionic acid
FR2189046B1 (fr) * 1972-06-22 1978-07-28 Farmaceutici Italia
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4609731A (en) * 1979-10-10 1986-09-02 Sandoz Ltd. Process for brominating ergot alkaloids
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
CH649300A5 (de) * 1981-08-07 1985-05-15 Sandoz Ag Ergopeptinderivate, ihre herstellung und verwendung.
DE3340025C2 (de) * 1983-11-03 1986-01-09 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen

Also Published As

Publication number Publication date
YU100886A (en) 1988-04-30
IT8620761A0 (it) 1986-06-11
IT8620761A1 (it) 1987-12-11
CS262670B2 (en) 1989-03-14
GB8614342D0 (en) 1986-07-16
GB2176479B (en) 1988-12-14
US4697017A (en) 1987-09-29
HU193317B (en) 1987-09-28
JPS61286390A (ja) 1986-12-16
FR2583419A1 (fr) 1986-12-19
HUT40445A (en) 1986-12-28
CH667092A5 (de) 1988-09-15
ES555932A0 (es) 1987-07-16
DE3619617A1 (de) 1986-12-18
CS435886A2 (en) 1988-08-16
IT1191806B (it) 1988-03-23
BE904897A (fr) 1986-12-10
CA1256103A (fr) 1989-06-20
GB2176479A (en) 1986-12-31
ES8707236A1 (es) 1987-07-16

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Legal Events

Date Code Title Description
ST Notification of lapse