FR2572406B1 - Procede pour la preparation d'acides diphosphoniques - Google Patents

Procede pour la preparation d'acides diphosphoniques

Info

Publication number
FR2572406B1
FR2572406B1 FR858515062A FR8515062A FR2572406B1 FR 2572406 B1 FR2572406 B1 FR 2572406B1 FR 858515062 A FR858515062 A FR 858515062A FR 8515062 A FR8515062 A FR 8515062A FR 2572406 B1 FR2572406 B1 FR 2572406B1
Authority
FR
France
Prior art keywords
preparation
diphosphonic acids
diphosphonic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR858515062A
Other languages
English (en)
Other versions
FR2572406A1 (fr
Inventor
Giorgio Staibano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Gentili SpA
Original Assignee
Istituto Gentili SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Gentili SpA filed Critical Istituto Gentili SpA
Publication of FR2572406A1 publication Critical patent/FR2572406A1/fr
Application granted granted Critical
Publication of FR2572406B1 publication Critical patent/FR2572406B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR858515062A 1984-10-29 1985-10-11 Procede pour la preparation d'acides diphosphoniques Expired FR2572406B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Publications (2)

Publication Number Publication Date
FR2572406A1 FR2572406A1 (fr) 1986-05-02
FR2572406B1 true FR2572406B1 (fr) 1989-04-07

Family

ID=11206414

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858515062A Expired FR2572406B1 (fr) 1984-10-29 1985-10-11 Procede pour la preparation d'acides diphosphoniques

Country Status (13)

Country Link
US (1) US4705651A (fr)
JP (1) JPS61109794A (fr)
AT (1) AT391702B (fr)
BE (1) BE903519A (fr)
CH (1) CH663791A5 (fr)
DE (1) DE3535404A1 (fr)
FR (1) FR2572406B1 (fr)
GB (1) GB2166741B (fr)
HK (1) HK12891A (fr)
IT (1) IT1196315B (fr)
LU (1) LU86133A1 (fr)
NL (1) NL193945C (fr)
SE (1) SE464084B (fr)

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DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0736804U (ja) * 1993-12-25 1995-07-11 松本 純子 指圧クッションシート
US5773429A (en) * 1996-12-11 1998-06-30 Fuisz Technologies Ltd. Drug combination for treating calcium loss
CA2197267C (fr) * 1997-02-11 2000-02-08 Yong Tao Procede pour la preparation de l'acide 4-amino-1-hydroxybutylidene-1,1-bisphosphonique ou de ses sels
WO2000012517A1 (fr) * 1998-08-27 2000-03-09 Teva Pharmaceutical Industries Ltd. Formes de type hydrate et formes cristallines de l'alendronate, sel de sodium, procedes de fabrication, et compositions pharmaceutiques renfermant ces formes
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
IL144941A0 (en) * 1999-02-17 2002-06-30 Teva Pharma Novel process for preparing alendronic acid
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6562974B2 (en) * 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6881420B2 (en) 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
DE60235085D1 (de) 2001-07-16 2010-03-04 Univ Paris Xiii Herstellungsverfahren von derivate von bisphosphonaten
MXPA04006027A (es) * 2001-12-21 2004-09-27 Procter & Gamble Metodo para el tratamiento de trastornos de los huesos.
KR20140021045A (ko) * 2002-05-10 2014-02-19 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
JP4427453B2 (ja) * 2002-12-20 2010-03-10 エフ．ホフマン−ラ ロシュ アーゲー 高用量イバンドロネート製剤
CN1325506C (zh) * 2003-05-15 2007-07-11 中国科学院上海药物研究所 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
US7411087B2 (en) * 2003-08-21 2008-08-12 Sun Pharmaceutical Industries Limited Process for preparation of bisphosphonic acid compounds
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
JPWO2006062072A1 (ja) * 2004-12-10 2008-08-07 テムリック株式会社 転移癌治療剤および癌転移抑制剤
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
EP2842559A3 (fr) 2005-04-08 2015-03-18 Chimerix, Inc. Composes, compositions et methodes de traitement d'infections virales et autres troubles medicaux
WO2006110655A2 (fr) 2005-04-08 2006-10-19 Chimerix, Inc. Composes, compositions et methodes de traitement des infections a poxvirus
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
PT1803727E (pt) * 2005-12-27 2009-06-15 Ipca Lab Ltd Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (fr) 2006-01-20 2007-07-26 Aurobindo Pharma Limited Procede ameliore de preparation d’acides bisphosphoniques
CA2713105C (fr) * 2008-01-25 2016-06-07 Chimerix, Inc. Methodes de traitement d'infections virales
US7964584B2 (en) * 2008-08-01 2011-06-21 Dong Wha Pharmaceutical Co., Ltd. Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (fr) 2009-08-03 2011-02-10 Chimerix, Inc. Composition et methodes de traitement des infections virales et des tumeurs d'origine virale
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
EP2563367A4 (fr) 2010-04-26 2013-12-04 Chimerix Inc Méthodes de traitement d'infections rétrovirales et régimes posologiques associés
TR201100153A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Efervesan bifosfonat formülasyonları.
WO2012093974A1 (fr) 2011-01-06 2012-07-12 Mahmut Bilgic Formulations améliorées de bisphosphonates
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
EP3164136A4 (fr) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Composés de promédicaments et leurs utilisations
CA3087932A1 (fr) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Composes acetal et leurs utilisations therapeutiques

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060546A (en) * 1961-07-03 1977-11-29 Henkel Kommanditgesellschaft Auf Aktien Process for the manufacture of acylation products of phosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2846835A1 (de) * 1978-10-27 1980-05-08 Benckiser Knapsack Gmbh Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
SU783300A1 (ru) * 1978-12-05 1980-11-30 Предприятие П/Я А-7346 Способ получени оксиэтилидендифосфоновой кислоты
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
GB2082585A (en) * 1980-08-27 1982-03-10 Vysoka Skola Chem Tech 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts.
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure

Also Published As

Publication number Publication date
SE464084B (sv) 1991-03-04
ATA292885A (de) 1990-05-15
NL8502949A (nl) 1986-05-16
GB2166741B (en) 1988-07-20
LU86133A1 (fr) 1986-03-24
SE8504687L (sv) 1986-04-30
JPS61109794A (ja) 1986-05-28
DE3535404C2 (fr) 1989-04-20
US4705651A (en) 1987-11-10
DE3535404A1 (de) 1986-04-30
IT8423362A0 (it) 1984-10-29
NL193945B (nl) 2000-11-01
HK12891A (en) 1991-03-08
AT391702B (de) 1990-11-26
NL193945C (nl) 2001-03-02
GB8524428D0 (en) 1985-11-06
FR2572406A1 (fr) 1986-05-02
JPH0569110B2 (fr) 1993-09-30
CH663791A5 (it) 1988-01-15
BE903519A (nl) 1986-02-17
IT1196315B (it) 1988-11-16
GB2166741A (en) 1986-05-14
SE8504687D0 (sv) 1985-10-09
IT8423362A1 (it) 1986-04-29

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