IT8423362A1 - Procedimento per la preparazione di acidi difosfonici - Google Patents

Procedimento per la preparazione di acidi difosfonici

Info

Publication number
IT8423362A1
IT8423362A1 IT1984A23362A IT2336284A IT8423362A1 IT 8423362 A1 IT8423362 A1 IT 8423362A1 IT 1984A23362 A IT1984A23362 A IT 1984A23362A IT 2336284 A IT2336284 A IT 2336284A IT 8423362 A1 IT8423362 A1 IT 8423362A1
Authority
IT
Italy
Prior art keywords
procedure
preparation
diphosphonic acids
diphosphonic
acids
Prior art date
Application number
IT1984A23362A
Other languages
English (en)
Other versions
IT8423362A0 (it
IT1196315B (it
Original Assignee
St Gentili S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Gentili S P A filed Critical St Gentili S P A
Publication of IT8423362A0 publication Critical patent/IT8423362A0/it
Priority to IT23362/84A priority Critical patent/IT1196315B/it
Priority to CH4239/85A priority patent/CH663791A5/it
Priority to GB08524428A priority patent/GB2166741B/en
Priority to DE19853535404 priority patent/DE3535404A1/de
Priority to SE8504687A priority patent/SE464084B/sv
Priority to AT0292885A priority patent/AT391702B/de
Priority to US06/786,815 priority patent/US4705651A/en
Priority to FR858515062A priority patent/FR2572406B1/fr
Priority to JP60232271A priority patent/JPS61109794A/ja
Priority to LU86133A priority patent/LU86133A1/fr
Priority to BE2/60826A priority patent/BE903519A/nl
Priority to NL8502949A priority patent/NL193945C/nl
Publication of IT8423362A1 publication Critical patent/IT8423362A1/it
Application granted granted Critical
Publication of IT1196315B publication Critical patent/IT1196315B/it
Priority to HK128/91A priority patent/HK12891A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IT23362/84A 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici IT1196315B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici
CH4239/85A CH663791A5 (it) 1984-10-29 1985-10-01 Procedimento per la preparazione di acidi difosfonici.
GB08524428A GB2166741B (en) 1984-10-29 1985-10-03 Process for the preparation of diphosphonic acids
DE19853535404 DE3535404A1 (de) 1984-10-29 1985-10-03 Verfahren zur herstellung von diphosphonsaeuren
SE8504687A SE464084B (sv) 1984-10-29 1985-10-09 Foerfarande foer framstaellning av 4-amino-1-hydroxi-butylidendifosfonsyra och 6-amino-1-hydroxihexylidendifosfonsyra
AT0292885A AT391702B (de) 1984-10-29 1985-10-10 Verfahren zur herstellung von diphosphonsaeuren
US06/786,815 US4705651A (en) 1984-10-29 1985-10-11 Process for the preparation of diphosphonic acids
FR858515062A FR2572406B1 (fr) 1984-10-29 1985-10-11 Procede pour la preparation d'acides diphosphoniques
JP60232271A JPS61109794A (ja) 1984-10-29 1985-10-17 ジホスホン酸類の製法
LU86133A LU86133A1 (fr) 1984-10-29 1985-10-23 Procede pour la preparation d'acides diphosphoniques
BE2/60826A BE903519A (nl) 1984-10-29 1985-10-25 Werkwijze voor het bereiden van difosfonzuren.
NL8502949A NL193945C (nl) 1984-10-29 1985-10-29 Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur.
HK128/91A HK12891A (en) 1984-10-29 1991-02-28 Process for the preparation of diphosphonic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Publications (3)

Publication Number Publication Date
IT8423362A0 IT8423362A0 (it) 1984-10-29
IT8423362A1 true IT8423362A1 (it) 1986-04-29
IT1196315B IT1196315B (it) 1988-11-16

Family

ID=11206414

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Country Status (13)

Country Link
US (1) US4705651A (it)
JP (1) JPS61109794A (it)
AT (1) AT391702B (it)
BE (1) BE903519A (it)
CH (1) CH663791A5 (it)
DE (1) DE3535404A1 (it)
FR (1) FR2572406B1 (it)
GB (1) GB2166741B (it)
HK (1) HK12891A (it)
IT (1) IT1196315B (it)
LU (1) LU86133A1 (it)
NL (1) NL193945C (it)
SE (1) SE464084B (it)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0736804U (ja) * 1993-12-25 1995-07-11 松本 純子 指圧クッションシート
US5773429A (en) * 1996-12-11 1998-06-30 Fuisz Technologies Ltd. Drug combination for treating calcium loss
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US6281381B1 (en) 1998-08-27 2001-08-28 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
HK1041004B (en) * 1999-02-17 2005-01-21 Teva Pharmaceutical Industries Ltd. Process for preparing alendronic acid
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
PE20011065A1 (es) * 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US6881420B2 (en) * 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
ATE455121T1 (de) 2001-07-16 2010-01-15 Univ Paris 13 Herstellungsverfahren von derivate von bisphosphonaten
NZ532994A (en) * 2001-12-21 2008-05-30 Procter & Gamble Method for the treatment of bone disorders using a bisphosphonate regimen, risedronate in particular
BR0308901A (pt) * 2002-05-10 2005-01-04 Hoffmann La Roche ácidos bisfosfÈnicos para tratamento e prevenção de osteoporose
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
AU2003250218B2 (en) * 2002-12-20 2006-10-26 F. Hoffmann-La Roche Ag High dose Ibandronate formulation
CN1325506C (zh) * 2003-05-15 2007-07-11 中国科学院上海药物研究所 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
ATE451380T1 (de) 2003-08-21 2009-12-15 Sun Pharmaceuticals Ind Ltd Verfahren zur herstellung von bisphosphonsäureverbindungen
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
WO2006062072A1 (ja) * 2004-12-10 2006-06-15 Tmrc Co., Ltd. 転移癌治療剤および癌転移抑制剤
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
ES2323728T3 (es) 2005-12-27 2009-07-23 Ipca Laboratories Limited Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
US8993542B2 (en) * 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
US7964584B2 (en) * 2008-08-01 2011-06-21 Dong Wha Pharmaceutical Co., Ltd. Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
JP2013501056A (ja) 2009-08-03 2013-01-10 キメリクス，インコーポレイテッド ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法
AU2011216243B2 (en) 2010-02-12 2015-07-09 Chimerix, Inc. Nucleoside phosphonate salts
EP2563367A4 (en) 2010-04-26 2013-12-04 Chimerix Inc Methods of treating retroviral infections and related dosage regimes
TR201100153A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Efervesan bifosfonat formülasyonları.
EP2661262B1 (en) 2011-01-06 2017-11-15 Mahmut Bilgic Improved bisphosphonate formulations
EP3105238A4 (en) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060546A (en) * 1961-07-03 1977-11-29 Henkel Kommanditgesellschaft Auf Aktien Process for the manufacture of acylation products of phosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2846835A1 (de) * 1978-10-27 1980-05-08 Benckiser Knapsack Gmbh Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
SU783300A1 (ru) * 1978-12-05 1980-11-30 Предприятие П/Я А-7346 Способ получени оксиэтилидендифосфоновой кислоты
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
GB2082585A (en) * 1980-08-27 1982-03-10 Vysoka Skola Chem Tech 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts.
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure

Also Published As

Publication number Publication date
ATA292885A (de) 1990-05-15
JPH0569110B2 (it) 1993-09-30
FR2572406A1 (fr) 1986-05-02
DE3535404A1 (de) 1986-04-30
CH663791A5 (it) 1988-01-15
FR2572406B1 (fr) 1989-04-07
SE464084B (sv) 1991-03-04
NL8502949A (nl) 1986-05-16
GB8524428D0 (en) 1985-11-06
AT391702B (de) 1990-11-26
US4705651A (en) 1987-11-10
IT8423362A0 (it) 1984-10-29
DE3535404C2 (it) 1989-04-20
IT1196315B (it) 1988-11-16
LU86133A1 (fr) 1986-03-24
GB2166741B (en) 1988-07-20
NL193945B (nl) 2000-11-01
HK12891A (en) 1991-03-08
GB2166741A (en) 1986-05-14
BE903519A (nl) 1986-02-17
NL193945C (nl) 2001-03-02
SE8504687L (sv) 1986-04-30
JPS61109794A (ja) 1986-05-28
SE8504687D0 (sv) 1985-10-09

Similar Documents

Publication Publication Date Title
IT1196315B (it) Procedimento per la preparazione di acidi difosfonici
DK325685A (da) Fremgangsmaade til fremstilling af halogenerede quinoloncarboxylsyrer
IT8421622A1 (it) Procedimento per la preparazione di peptidi
IT1200400B (it) Procedimento per la preparazione di 2-alchil ciclopent-2-enoni
IT8567535A0 (it) Procedimento per la preparazione di amminoidrossicefamcarbossilati
IT8419403A0 (it) Procedimento per la preparazione di l-alfa-amminoacidi.
IT1200594B (it) Procedimento per la preparazione di alfa-omega-aloperfluorocarburi
IT1128163B (it) Procedimento per la preparazione di acidi alcanoici
IT1170545B (it) Procedimento per la produzione di acidi amminociclopentanoici
IT8548297A0 (it) Procedimento per la preparazione di r(-)-norcarnitina terz-butil estere
IT1190358B (it) Procedimento per la preparazione di l-carnitina
IT1191806B (it) Procedimento per la preparazione di 2-bromo-alfa-ergocriptina
ES545512A0 (es) Procedimiento para la preparacion de acidos arilalcanoicos
IT1138463B (it) Procedimento per la preparazione di acidi dialurici 5-sostituiti
IT8567469A0 (it) Procedimento per la preparazionedi n benzilossicarbonil amminoacidi contenenti funzionalita addizionali
NO863388L (no) Fremgangsmaate ved fremstilling av cyclohexanalkansyrer.
IT1198399B (it) Procedimento di preparazione di acidi fenossibenzoici
FI864790A7 (fi) 5-kloori- ja 5-bromi-2 -hydroksinikotiinihappojen valmistusmenetelmä.
IT1207420B (it) Acidi carbossilici. procedimento per la preparazione di
IT1175989B (it) Procedimento per la preparazione di polifenileteri
IT1212788B (it) Procedimento per la preparazione di acidi n-cinnamoilantranilici.
NO920816D0 (no) Fremgangsmaate for fremstilling av alfa-arylalkansyrer
IT1144924B (it) Procedimento per la preparazione di amminoacidi
IT1196167B (it) Procedimento per la preparazione di n-tiocarbossianidridi di amminoacidi
IT1132221B (it) Procedimento per la preparazione di acidi fenossiacetici

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971029