ATA47292A - Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben - Google Patents
Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselbenInfo
- Publication number
- ATA47292A ATA47292A AT0047292A AT47292A ATA47292A AT A47292 A ATA47292 A AT A47292A AT 0047292 A AT0047292 A AT 0047292A AT 47292 A AT47292 A AT 47292A AT A47292 A ATA47292 A AT A47292A
- Authority
- AT
- Austria
- Prior art keywords
- isolating
- new method
- clavulanic acid
- compatible salts
- pharmacologically compatible
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0047292A AT400033B (de) | 1992-03-10 | 1992-03-10 | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
CH670/93A CH685054A5 (de) | 1992-03-10 | 1993-03-05 | Verfahren zur Herstellung von Clavulansäuresalzen. |
NO930829A NO301372B1 (no) | 1992-03-10 | 1993-03-08 | Fremgangsmåte for fremstilling av et farmasöytisk tålbart salt av klavulansyre |
GB9304704A GB2264944B (en) | 1992-03-10 | 1993-03-08 | Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid |
SE9300758A SE508043C2 (sv) | 1992-03-10 | 1993-03-08 | Förfarande för framställning och användning av 2-amino-2,4,4- trimetylpentansaltet av klavulansyra som mellanprodukt vid framställning av farmaceutiskt godtagbara salter av klavulansyra |
JP5046691A JP2817563B2 (ja) | 1992-03-10 | 1993-03-08 | クラブラン酸塩の製造方法 |
GR930100090A GR1002329B (el) | 1992-03-10 | 1993-03-09 | Μεθοδος για την παραγωγη αλατων κλαβουλανικου οξεος. |
IE930172A IE70926B1 (en) | 1992-03-10 | 1993-03-09 | Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid |
DE4307422A DE4307422B4 (de) | 1992-03-10 | 1993-03-09 | Verfahren zur Herstellung von Clavulansäuresalzen |
DK026093A DK26093A (da) | 1992-03-10 | 1993-03-09 | Fremgangsmaade til fremstilling af clavulansyresalte |
FI931032A FI101965B (fi) | 1992-03-10 | 1993-03-09 | Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaa nihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa |
CN93102897A CN1045604C (zh) | 1992-03-10 | 1993-03-09 | 棒酸盐的制备方法 |
FR9302720A FR2688506B1 (fr) | 1992-03-10 | 1993-03-09 | Procede de preparation de sels de l'acide clavulanique. |
AU34070/93A AU659282B2 (en) | 1992-03-10 | 1993-03-09 | Process for the production of pharmaceutically acceptable salts of clavulanic acid |
NL9300430A NL9300430A (nl) | 1992-03-10 | 1993-03-10 | Werkwijze voor het bereiden van zouten van clavulaanzuur. |
ITRM930147A IT1261213B (it) | 1992-03-10 | 1993-03-10 | Procedimento per la preparazione di sali dell'acido clavulanico. |
ES09300483A ES2058029B1 (es) | 1992-03-10 | 1993-03-10 | Proceso para la produccion de sales del acido clavulanico. |
TW082103491A TW364907B (en) | 1992-03-10 | 1993-05-04 | Process for the production of the potassium salt of clavulanic acid via the 2-amino-2,4,4-trimethylpentane salt thereof |
HK42696A HK42696A (en) | 1992-03-10 | 1996-03-14 | Use of 2-amino-2 4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid |
CN96108278A CN1150153A (zh) | 1992-03-10 | 1996-06-29 | 2-氨基-2,4,4-三甲基戊烷棒酸盐的应用 |
CN96108276A CN1145906A (zh) | 1992-03-10 | 1996-06-29 | 药用棒酸盐的制造方法 |
JP9218732A JPH1067785A (ja) | 1992-03-10 | 1997-08-13 | クラブラン酸の2−アミノ−2,4,4−トリメチルペンタン塩 |
CY199597A CY1995A (en) | 1992-03-10 | 1997-09-05 | Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid |
US09/892,179 US20010036940A1 (en) | 1992-03-10 | 2001-06-26 | Process for the production of clavulanic acid salts |
US10/071,364 US20020072513A1 (en) | 1992-03-10 | 2002-02-08 | Process for the production of clavulanic acid salts |
US10/251,948 US20030022882A1 (en) | 1992-03-10 | 2002-09-20 | Process for the production of clavulanic acid salts |
US10/437,097 USH2158H1 (en) | 1992-03-10 | 2003-05-13 | Process for the production of clavulanic acid salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0047292A AT400033B (de) | 1992-03-10 | 1992-03-10 | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA47292A true ATA47292A (de) | 1995-01-15 |
AT400033B AT400033B (de) | 1995-09-25 |
Family
ID=3491521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0047292A AT400033B (de) | 1992-03-10 | 1992-03-10 | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
Country Status (21)
Country | Link |
---|---|
US (4) | US20010036940A1 (de) |
JP (2) | JP2817563B2 (de) |
CN (3) | CN1045604C (de) |
AT (1) | AT400033B (de) |
AU (1) | AU659282B2 (de) |
CH (1) | CH685054A5 (de) |
CY (1) | CY1995A (de) |
DE (1) | DE4307422B4 (de) |
DK (1) | DK26093A (de) |
ES (1) | ES2058029B1 (de) |
FI (1) | FI101965B (de) |
FR (1) | FR2688506B1 (de) |
GB (1) | GB2264944B (de) |
GR (1) | GR1002329B (de) |
HK (1) | HK42696A (de) |
IE (1) | IE70926B1 (de) |
IT (1) | IT1261213B (de) |
NL (1) | NL9300430A (de) |
NO (1) | NO301372B1 (de) |
SE (1) | SE508043C2 (de) |
TW (1) | TW364907B (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT399155B (de) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
SI9300296B (sl) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
DE69427312T2 (de) | 1993-11-17 | 2001-08-23 | Biochemie Ges.M.B.H., Kundl | Trennung von Cephalosporinisomeren |
GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
DE69618045D1 (de) * | 1995-02-25 | 2002-01-31 | Spurcourt Ltd | Clavulansäure Salz |
KR100200242B1 (ko) * | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
CN1312814A (zh) * | 1998-07-16 | 2001-09-12 | Dsm公司 | 制备棒酸盐类及其酯类的改进方法 |
ATE260096T1 (de) * | 1999-04-01 | 2004-03-15 | Dsm Ip Assets Bv | Agglomerate durch kristallisation |
US7767823B2 (en) * | 2000-05-13 | 2010-08-03 | Smithkline Beecham Limited | Process for the purification of a salt of clavulanic acid |
KR20090004839A (ko) * | 2005-09-07 | 2009-01-12 | 제네렉스, 인코포레이티드 | Gm-csf를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법 |
JP7028064B2 (ja) | 2018-05-30 | 2022-03-02 | 横河電機株式会社 | 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体 |
EP4178710A1 (de) | 2020-07-10 | 2023-05-17 | Carbon Clean Solutions Limited | Verfahren und system zur entfernung von kohlendioxid aus lösungsmitteln unter verwendung von niedrigwertiger wärme |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3288800A (en) | 1962-05-29 | 1966-11-29 | Squibb & Sons Inc | Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof |
GB1508977A (en) | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
IE41109B1 (en) | 1974-04-20 | 1979-10-24 | Beecham Group Ltd | Novel -lactam antibiotic from streptomyces clavuligerus |
US4110165A (en) | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
GB1543563A (en) | 1975-02-07 | 1979-04-04 | Glaxo Lab Ltd | Beta-lactam antibiotic in purified form |
US4144242A (en) | 1975-02-07 | 1979-03-13 | Glaxo Laboratories Limited | Process for the purification of clavulanic acid |
GB1561395A (en) | 1976-02-26 | 1980-02-20 | Beecham Group Ltd | -lactam antibiotic |
GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
GB2003863B (en) | 1977-09-01 | 1982-03-31 | Beecham Group Ltd | Chemical process |
DE2861607D1 (en) | 1977-11-26 | 1982-03-11 | Beecham Group Plc | Derivatives of clavulanic acid and pharmaceutical compositions containing them |
BE862211A (fr) * | 1977-12-22 | 1978-06-22 | Beecham Group Ltd | Agents antibacteriens |
DE3063683D1 (en) | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
US4454069A (en) | 1979-08-24 | 1984-06-12 | Beecham Group Limited | Clavulanic acid salts and their preparation from the tertiary butyl amine salt |
NZ213963A (en) | 1984-10-27 | 1989-01-06 | Antibioticos Sa | Production of clavulanic acid |
GB8618888D0 (en) | 1986-08-01 | 1986-09-10 | Davy Mckee Ltd | Process |
US5679789A (en) | 1987-01-29 | 1997-10-21 | Beecham Group, P.L.C. | Pharmaceutical compositions comprising potassium clavulanate and methods of using them |
PT86631B (pt) | 1987-01-29 | 1992-01-31 | Beecham Group Plc | Processo para a preparacao de uma nova forma cristalina de clavulanato de potassio |
ES2010143A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
US5210296A (en) | 1990-11-19 | 1993-05-11 | E. I. Du Pont De Nemours And Company | Recovery of lactate esters and lactic acid from fermentation broth |
AT399155B (de) | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
SI9300296B (sl) | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
SI9200139A (en) | 1992-07-08 | 1994-03-31 | Lek Tovarna Farmacevtskih | New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them |
KR100200239B1 (ko) | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
GB9401969D0 (en) | 1994-02-02 | 1994-03-30 | Smithkline Beecham Plc | Process |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB2298201B (en) | 1995-02-25 | 1997-05-28 | Spurcourt Ltd | Clavulanic acid salts |
DE69618045D1 (de) | 1995-02-25 | 2002-01-31 | Spurcourt Ltd | Clavulansäure Salz |
SI9500074A (en) | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
KR100200242B1 (ko) | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
GB9515809D0 (en) | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
SI9500265A1 (en) | 1995-08-28 | 1997-02-28 | Lek Tovarna Farmacevtskih | Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration |
ZA975198B (en) | 1996-06-13 | 1997-12-15 | Smithkline Beecham Corp | Improved process for preparing potassium clavulanate. |
CN1238776A (zh) | 1996-11-11 | 1999-12-15 | 吉斯特-布罗卡迪斯有限公司 | 制备棒酸盐和酯的方法 |
-
1992
- 1992-03-10 AT AT0047292A patent/AT400033B/de not_active IP Right Cessation
-
1993
- 1993-03-05 CH CH670/93A patent/CH685054A5/de not_active IP Right Cessation
- 1993-03-08 GB GB9304704A patent/GB2264944B/en not_active Expired - Fee Related
- 1993-03-08 JP JP5046691A patent/JP2817563B2/ja not_active Expired - Fee Related
- 1993-03-08 SE SE9300758A patent/SE508043C2/sv not_active IP Right Cessation
- 1993-03-08 NO NO930829A patent/NO301372B1/no unknown
- 1993-03-09 GR GR930100090A patent/GR1002329B/el not_active IP Right Cessation
- 1993-03-09 DE DE4307422A patent/DE4307422B4/de not_active Expired - Fee Related
- 1993-03-09 AU AU34070/93A patent/AU659282B2/en not_active Ceased
- 1993-03-09 FR FR9302720A patent/FR2688506B1/fr not_active Expired - Fee Related
- 1993-03-09 CN CN93102897A patent/CN1045604C/zh not_active Expired - Fee Related
- 1993-03-09 IE IE930172A patent/IE70926B1/en not_active IP Right Cessation
- 1993-03-09 DK DK026093A patent/DK26093A/da not_active Application Discontinuation
- 1993-03-09 FI FI931032A patent/FI101965B/fi active
- 1993-03-10 NL NL9300430A patent/NL9300430A/nl active Search and Examination
- 1993-03-10 ES ES09300483A patent/ES2058029B1/es not_active Expired - Fee Related
- 1993-03-10 IT ITRM930147A patent/IT1261213B/it active IP Right Grant
- 1993-05-04 TW TW082103491A patent/TW364907B/zh not_active IP Right Cessation
-
1996
- 1996-03-14 HK HK42696A patent/HK42696A/xx not_active IP Right Cessation
- 1996-06-29 CN CN96108276A patent/CN1145906A/zh active Pending
- 1996-06-29 CN CN96108278A patent/CN1150153A/zh active Pending
-
1997
- 1997-08-13 JP JP9218732A patent/JPH1067785A/ja active Pending
- 1997-09-05 CY CY199597A patent/CY1995A/xx unknown
-
2001
- 2001-06-26 US US09/892,179 patent/US20010036940A1/en not_active Abandoned
-
2002
- 2002-02-08 US US10/071,364 patent/US20020072513A1/en not_active Abandoned
- 2002-09-20 US US10/251,948 patent/US20030022882A1/en not_active Abandoned
-
2003
- 2003-05-13 US US10/437,097 patent/USH2158H1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee |