ATE189804T1 - Selektives verfahren zur deacylierung von acylverbindungen - Google Patents

Selektives verfahren zur deacylierung von acylverbindungen

Info

Publication number
ATE189804T1
ATE189804T1 AT96928423T AT96928423T ATE189804T1 AT E189804 T1 ATE189804 T1 AT E189804T1 AT 96928423 T AT96928423 T AT 96928423T AT 96928423 T AT96928423 T AT 96928423T AT E189804 T1 ATE189804 T1 AT E189804T1
Authority
AT
Austria
Prior art keywords
deacylation
acyl compounds
selective process
statins
fermentation broth
Prior art date
Application number
AT96928423T
Other languages
English (en)
Inventor
Pater Robertus Mattheus De
Mieke Sibeyn
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of ATE189804T1 publication Critical patent/ATE189804T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
AT96928423T 1995-08-03 1996-08-05 Selektives verfahren zur deacylierung von acylverbindungen ATE189804T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US186095P 1995-08-03 1995-08-03
EP95202125 1995-08-03
PCT/EP1996/003495 WO1997006128A1 (en) 1995-08-03 1996-08-05 Selective process for the deacylation of acylated compounds

Publications (1)

Publication Number Publication Date
ATE189804T1 true ATE189804T1 (de) 2000-03-15

Family

ID=26139544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928423T ATE189804T1 (de) 1995-08-03 1996-08-05 Selektives verfahren zur deacylierung von acylverbindungen

Country Status (15)

Country Link
EP (1) EP0784605B1 (de)
JP (1) JPH11501218A (de)
CN (1) CN1078583C (de)
AT (1) ATE189804T1 (de)
AU (1) AU6820096A (de)
CA (1) CA2201729C (de)
DE (1) DE69606696T2 (de)
DK (1) DK0784605T3 (de)
ES (1) ES2145479T3 (de)
GR (1) GR3033402T3 (de)
HU (1) HU221636B1 (de)
MX (1) MX9702403A (de)
PT (1) PT784605E (de)
SI (1) SI0784605T1 (de)
WO (1) WO1997006128A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0251582A (ja) * 1988-08-12 1990-02-21 Kyokado Eng Co Ltd 地盤注入用薬液
US6165757A (en) * 1997-02-20 2000-12-26 Dsm N.V. Nitrogen feed in statin fermentation
EP0877089A1 (de) * 1997-05-07 1998-11-11 Gist-Brocades B.V. Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
CZ20031166A3 (cs) * 2000-10-05 2004-04-14 Biogal Gyogyszergyar Rt Sodná sůl pravastatinu, která v podstatě neobsahuje pravastatin lakton a epi-pravastatin a kompozice na její bázi
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
EP1477471A1 (de) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Verfahren zur Reinigung von Pravastin-Natrium aus einer Fermentationsbrühe
US7425644B2 (en) 2003-11-24 2008-09-16 TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
GB2255974A (en) * 1991-05-24 1992-11-25 Merck & Co Inc Enzymatic deacylation of simvastatin

Also Published As

Publication number Publication date
HUP9702444A3 (en) 1999-10-28
CN1078583C (zh) 2002-01-30
PT784605E (pt) 2000-08-31
AU6820096A (en) 1997-03-05
JPH11501218A (ja) 1999-02-02
ES2145479T3 (es) 2000-07-01
CN1164851A (zh) 1997-11-12
CA2201729A1 (en) 1997-02-20
SI0784605T1 (en) 2000-08-31
WO1997006128A1 (en) 1997-02-20
DK0784605T3 (da) 2000-07-31
DE69606696T2 (de) 2000-08-17
CA2201729C (en) 2002-03-12
HUP9702444A1 (hu) 1998-04-28
MX9702403A (es) 1997-06-28
DE69606696D1 (de) 2000-03-23
EP0784605A1 (de) 1997-07-23
EP0784605B1 (de) 2000-02-16
HU221636B1 (hu) 2002-12-28
GR3033402T3 (en) 2000-09-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee