DE60031447D1 - Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe - Google Patents

Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe

Info

Publication number
DE60031447D1
DE60031447D1 DE60031447T DE60031447T DE60031447D1 DE 60031447 D1 DE60031447 D1 DE 60031447D1 DE 60031447 T DE60031447 T DE 60031447T DE 60031447 T DE60031447 T DE 60031447T DE 60031447 D1 DE60031447 D1 DE 60031447D1
Authority
DE
Germany
Prior art keywords
recovery
statin compounds
fermentation brew
brew
fermentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60031447T
Other languages
English (en)
Other versions
DE60031447T2 (de
Inventor
Vilmos Keri
Lajos Deak
Ilona Forgacs
Csaba Szabo
Arvai NAGYNE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Teva Pharmaceutical Works PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22609918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60031447(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Works PLC filed Critical Teva Pharmaceutical Works PLC
Application granted granted Critical
Publication of DE60031447D1 publication Critical patent/DE60031447D1/de
Publication of DE60031447T2 publication Critical patent/DE60031447T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacturing & Machinery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60031447T 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe Expired - Fee Related DE60031447T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16805699P 1999-11-30 1999-11-30
US168056P 1999-11-30
PCT/US2000/032391 WO2001039768A1 (en) 1999-11-30 2000-11-28 Process for recovering statin compounds from a fermentation broth

Publications (2)

Publication Number Publication Date
DE60031447D1 true DE60031447D1 (de) 2006-11-30
DE60031447T2 DE60031447T2 (de) 2007-08-30

Family

ID=22609918

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60031447T Expired - Fee Related DE60031447T2 (de) 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
DE04010770T Pending DE04010770T1 (de) 1999-11-30 2000-11-28 Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
DE60037687T Expired - Lifetime DE60037687D1 (de) 1999-11-30 2000-11-28 Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE04010770T Pending DE04010770T1 (de) 1999-11-30 2000-11-28 Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe
DE60037687T Expired - Lifetime DE60037687D1 (de) 1999-11-30 2000-11-28 Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe

Country Status (22)

Country Link
US (3) US6444452B1 (de)
EP (1) EP1265604B1 (de)
JP (5) JP3881240B2 (de)
KR (1) KR20030026920A (de)
CN (2) CN1433305A (de)
AT (2) ATE342717T1 (de)
AU (1) AU1804601A (de)
CA (1) CA2393057C (de)
CY (1) CY1105925T1 (de)
DE (3) DE60031447T2 (de)
DK (1) DK1265604T3 (de)
ES (2) ES2273737T3 (de)
HR (1) HRP20020454A2 (de)
HU (1) HUP0204012A3 (de)
MX (1) MXPA02005283A (de)
PL (1) PL364918A1 (de)
PT (1) PT1265604E (de)
RU (1) RU2002114072A (de)
SK (1) SK7342002A3 (de)
WO (1) WO2001039768A1 (de)
YU (1) YU39102A (de)
ZA (1) ZA200203912B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
MXPA02005283A (es) * 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
IL150187A0 (en) * 1999-12-14 2002-12-01 Biogal Pharmaceutical Co Ltd Novel forms of pravastatin sodium
EP1330245A4 (de) * 2000-10-05 2004-10-20 Biogal Gyogyszergyar Pravastatin-natrium, das im wesentlichen frei von pravastatin-lacton und epipravastatin ist, und dieses enthaltende zusammensetzungen
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
JP2002121172A (ja) * 2000-10-16 2002-04-23 Sankyo Co Ltd プラバスタチン又はその薬理上許容される塩の精製方法
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1477471A1 (de) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Verfahren zur Reinigung von Pravastin-Natrium aus einer Fermentationsbrühe
DE602004017461D1 (de) * 2003-11-24 2008-12-11 Teva Gyogyszergyar Zartkoeruen Verfahren zur reinigung von pravastatin
EP1697383B1 (de) * 2003-12-05 2014-04-23 Biocon Limited Verfahren zur aufreinigung von tacrolimus
WO2006046130A2 (en) * 2004-10-29 2006-05-04 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
TW200640854A (en) * 2005-02-09 2006-12-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of making pravastatin sodium
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
IN2009MU00380A (de) * 2009-02-18 2010-04-02
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
WO1998037220A1 (en) * 1997-02-20 1998-08-27 Dsm N.V. Nitrogen feed in statin fermentation
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
TR200600009T2 (tr) * 1999-02-03 2006-08-21 Institute For Drug Research Ltd. Pravastatinin hazırlanması için mikrobiyal işlem.@
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
MXPA02005283A (es) * 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
EP1330245A4 (de) * 2000-10-05 2004-10-20 Biogal Gyogyszergyar Pravastatin-natrium, das im wesentlichen frei von pravastatin-lacton und epipravastatin ist, und dieses enthaltende zusammensetzungen

Also Published As

Publication number Publication date
ZA200203912B (en) 2003-08-21
US20040115781A1 (en) 2004-06-17
JP4343987B2 (ja) 2009-10-14
EP1265604A1 (de) 2002-12-18
WO2001039768A1 (en) 2001-06-07
SK7342002A3 (en) 2004-03-02
CY1105925T1 (el) 2011-04-06
DK1265604T3 (da) 2007-02-05
US20020187531A1 (en) 2002-12-12
US6689590B2 (en) 2004-02-10
HUP0204012A2 (hu) 2003-03-28
EP1265604B1 (de) 2006-10-18
PL364918A1 (en) 2004-12-27
JP3881240B2 (ja) 2007-02-14
DE60031447T2 (de) 2007-08-30
CN1433305A (zh) 2003-07-30
US6444452B1 (en) 2002-09-03
DE04010770T1 (de) 2005-10-20
JP2003515334A (ja) 2003-05-07
EP1265604A4 (de) 2004-06-16
RU2002114072A (ru) 2004-07-20
ES2239937T1 (es) 2005-10-16
CN1754872A (zh) 2006-04-05
ES2273737T3 (es) 2007-05-16
KR20030026920A (ko) 2003-04-03
JP2006273861A (ja) 2006-10-12
JP2006055174A (ja) 2006-03-02
MXPA02005283A (es) 2003-10-06
PT1265604E (pt) 2006-12-29
AU1804601A (en) 2001-06-12
CA2393057A1 (en) 2001-06-07
ATE342717T1 (de) 2006-11-15
ATE382344T1 (de) 2008-01-15
YU39102A (sh) 2006-01-16
DE60037687D1 (de) 2008-02-14
HRP20020454A2 (en) 2005-10-31
JP2008109948A (ja) 2008-05-15
CA2393057C (en) 2008-01-29
HUP0204012A3 (en) 2003-12-29
JP2004350687A (ja) 2004-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee