CY1112350T1 - Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα - Google Patents

Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα

Info

Publication number
CY1112350T1
CY1112350T1 CY20111100748T CY111100748T CY1112350T1 CY 1112350 T1 CY1112350 T1 CY 1112350T1 CY 20111100748 T CY20111100748 T CY 20111100748T CY 111100748 T CY111100748 T CY 111100748T CY 1112350 T1 CY1112350 T1 CY 1112350T1
Authority
CY
Cyprus
Prior art keywords
oxoepoenic
optive
active
formula
manufacturing procedure
Prior art date
Application number
CY20111100748T
Other languages
English (en)
Inventor
Takashi Horiuchi
Masamichi Shimizu
Shoichi Kondo
Tadashi Soejima
Kazuhiro Umeo
Original Assignee
Nissan Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Industries, Ltd. filed Critical Nissan Chemical Industries, Ltd.
Publication of CY1112350T1 publication Critical patent/CY1112350T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Μία νέα διαδικασία παραγωγής ενός οπτικά ενεργού (Ε)-7- [2- κυκλοπροπυλο -4- (4-φθοροφαινυλο) κινολιν -3- υλ]-5- υδροξυ-3 - οξοεπτ-6- ενοϊκού όξινου εστέρα του τύπου (III) που είναι σημαντικός ως ένα ενδιάμεσο προϊόν για τη σύνθεση φαρμάκων, περιλαμβάνει την αντίδραση του 1,3-δι (τριμεθυλοσιλυλοξυ)-1-αλκοξυβουτά-1,3- διενίου του τύπου (I) με την (Ε)-3-[2- κυκλοπροπυλο-4- (4-φθοροφαινυλο) κινολιν-3- υλο] -προπ-2- εν-1- άλη του τύπου (II) παρουσία ενός οπτικά ενεργού συμπλόκου διναφθόλης - τιτανίου το οποίο εξασφαλίστηκε από την αντίδραση της 1,1'-δι-2-ναφθόλης με το τετραϊσοπροποξείδιο του τιτανίου, ενός μεταλλικού άλατος και μίας αμίνης, στη συνέχεια απομακρύνονται οι ομάδες πυριτίου (desilylation) από το προϊόν αντίδρασης.
CY20111100748T 2001-11-14 2011-08-04 Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα CY1112350T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001348569 2001-11-14
EP02780087A EP1466905B1 (en) 2001-11-14 2002-11-14 Process for producing optically active oxoheptenoic acid ester

Publications (1)

Publication Number Publication Date
CY1112350T1 true CY1112350T1 (el) 2015-12-09

Family

ID=19161371

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100748T CY1112350T1 (el) 2001-11-14 2011-08-04 Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα

Country Status (14)

Country Link
US (1) US7064209B2 (el)
EP (1) EP1466905B1 (el)
JP (1) JP4433156B2 (el)
KR (1) KR100919941B1 (el)
CN (1) CN1288136C (el)
AT (1) ATE509914T1 (el)
CA (1) CA2485580C (el)
CY (1) CY1112350T1 (el)
DK (1) DK1466905T3 (el)
ES (1) ES2364632T3 (el)
PT (1) PT1466905E (el)
TW (1) TWI243165B (el)
WO (1) WO2003042180A1 (el)
ZA (1) ZA200403722B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds
JP4524111B2 (ja) * 2002-01-31 2010-08-11 ノバルティス アーゲー ＨＭＧ−ＣｏＡ還元酵素阻害剤の製造法
GB0514078D0 (en) 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
KR100995882B1 (ko) * 2010-06-08 2010-11-22 에이치 엘 지노믹스(주) 피타바스타틴 또는 그의 염의 중간체의 제조방법
EP3178812A1 (en) * 2010-11-12 2017-06-14 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
JP2016188175A (ja) * 2013-08-30 2016-11-04 日産化学工業株式会社 光学活性５−ヒドロキシ−３−ケトエステル化合物の製造方法
CN105473542B (zh) * 2013-08-30 2018-12-04 日产化学工业株式会社 光学活性5-羟基-3-酮酯类的制造方法
JP6953142B2 (ja) * 2017-02-20 2021-10-27 株式会社トプコン 測定装置、測定方法及び測定装置の制御プログラム
JP7331058B2 (ja) * 2017-02-20 2023-08-22 株式会社トプコン 測定装置、測定方法及び測定装置の制御プログラム
DE102018215091A1 (de) 2018-09-05 2020-03-05 Robert Bosch Gmbh Projektionsvorrichtung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3554036B2 (ja) 1994-09-06 2004-08-11 宇部興産株式会社 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds

Also Published As

Publication number Publication date
WO2003042180A1 (fr) 2003-05-22
ZA200403722B (en) 2005-05-16
JP4433156B2 (ja) 2010-03-17
WO2003042180A9 (fr) 2003-07-31
CA2485580C (en) 2009-11-03
ATE509914T1 (de) 2011-06-15
TW200300085A (en) 2003-05-16
PT1466905E (pt) 2011-07-14
EP1466905B1 (en) 2011-05-18
EP1466905A4 (en) 2006-04-12
JPWO2003042180A1 (ja) 2005-03-10
CN1589263A (zh) 2005-03-02
EP1466905A1 (en) 2004-10-13
TWI243165B (en) 2005-11-11
DK1466905T3 (da) 2011-08-22
ES2364632T3 (es) 2011-09-08
CN1288136C (zh) 2006-12-06
KR20050044442A (ko) 2005-05-12
US20050054853A1 (en) 2005-03-10
CA2485580A1 (en) 2003-05-22
KR100919941B1 (ko) 2009-10-05
US7064209B2 (en) 2006-06-20

Similar Documents

Publication Publication Date Title
CY1112350T1 (el) Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα
NO303574B1 (no) Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner
ES2141748T3 (es) Procedimiento para produccion de alanilglutamina.
DK0554455T3 (da) Optisk aktivt mellemprodukt og fremstilling deraf
DE60226203D1 (de) Laktonisierung im Verfahren zur Herstellung von Statinen
EP1571138A4 (en) METHOD OF PREPARING (4E) -5-CHLORO-2-ISOPROPYL-4-PENIC ACID AND OPTICALLY ACTIVE ISOMER THEREOF
BR0317781A (pt) Processo para produção de derivado de benzilamina
EP1340743A4 (en) OPTICALLY ACTIVE AMINO DERIVATIVE AND METHOD OF SYNTHESIS
DE60105250D1 (de) Herstellungsverfahren zur 2-Cyclohexyl-2-hydroxy-Phenylessigsäure, Zwischenprodukt dafür und Herstellungsverfahren davon
BR0204943A (pt) Método de processamento de lactonização na preparação de estatinas
AU7961700A (en) Process for the preparation of 7-azabicyclo(4.1.0)-hept-3-ene-3-carboxylic acid esters
HU9200645D0 (en) Glyceraldehyde-3-pentanide and method for producing it
ATE337306T1 (de) Verfahren zur herstellung von optisch aktiven imidazolverbindungen, zwischenprodukte zu deren herstellung und ihre herstellung
BR0313622A (pt) Processo para produção de um composto
ATE506349T1 (de) Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat
EP1693364A4 (en) INTERMEDIATES FOR THE PRODUCTION OF OPTICALLY ACTIVE CYCLOPROPYLAMINE DERIVATIVES AND PROCESS FOR THE PRODUCTION THEREOF
ATE277064T1 (de) Verfahren zur herstellung von vinylpyrimidinderivaten
EP1650187A4 (en) OPTSCH AKTIVES 2-ALLYLCARBONSÄUREDERIVATIV AND METHOD FOR THE PRODUCTION THEREOF
GR3035317T3 (en) Preparation of optically active (S)-(-) and (R)-(+)- deoxyspergualin and novel intermediates thereof