ATE496907T1 - Verfahren zur herstellung von cilostazol - Google Patents
Verfahren zur herstellung von cilostazolInfo
- Publication number
- ATE496907T1 ATE496907T1 AT03788701T AT03788701T ATE496907T1 AT E496907 T1 ATE496907 T1 AT E496907T1 AT 03788701 T AT03788701 T AT 03788701T AT 03788701 T AT03788701 T AT 03788701T AT E496907 T1 ATE496907 T1 AT E496907T1
- Authority
- AT
- Austria
- Prior art keywords
- äiiü
- producing
- carbostyril derivative
- derivative
- water
- Prior art date
Links
- RRGUKTPIGVIEKM-UHFFFAOYSA-N cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960004588 cilostazol Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000007514 bases Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002264314 | 2002-09-10 | ||
| PCT/JP2003/011515 WO2004024716A1 (ja) | 2002-09-10 | 2003-09-09 | シロスタゾールの製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE496907T1 true ATE496907T1 (de) | 2011-02-15 |
Family
ID=31986513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03788701T ATE496907T1 (de) | 2002-09-10 | 2003-09-09 | Verfahren zur herstellung von cilostazol |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7026486B2 (de) |
| EP (1) | EP1489080B1 (de) |
| JP (1) | JP4629322B2 (de) |
| KR (1) | KR100551926B1 (de) |
| CN (1) | CN1257902C (de) |
| AT (1) | ATE496907T1 (de) |
| CY (1) | CY1111277T1 (de) |
| DE (1) | DE60335865D1 (de) |
| DK (1) | DK1489080T3 (de) |
| ES (1) | ES2358324T3 (de) |
| PT (1) | PT1489080E (de) |
| SI (1) | SI1489080T1 (de) |
| WO (1) | WO2004024716A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
| US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
| IL167483A (en) * | 2004-03-16 | 2011-04-28 | Chemagis Ltd | Process for obtaining highly pure cilostazol |
| WO2005123033A2 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | Fine particles of cilostazol and processes for production thereof |
| KR100633232B1 (ko) * | 2004-08-25 | 2006-10-11 | 주식회사유한양행 | 신규한 6-[4-(1-시클로헥실-1ｈ-테트라졸-5-일)부톡시]-3,4-디히드로-2(1ｈ)-퀴놀리논 정제방법 |
| US20080075785A1 (en) * | 2006-09-22 | 2008-03-27 | San-Laung Chow | Controlled release hydrogel formulation |
| US20110165236A1 (en) * | 2006-09-22 | 2011-07-07 | Biokey, Inc. | Controlled release hydrogel formulation |
| CN101434598B (zh) * | 2008-12-19 | 2012-11-07 | 重庆康乐制药有限公司 | 西洛他唑的制备方法 |
| CN102086190B (zh) * | 2011-01-28 | 2013-07-10 | 海南美兰史克制药有限公司 | 西洛他唑化合物及其制法 |
| CN107382970A (zh) * | 2017-07-26 | 2017-11-24 | 浙江金立源药业有限公司 | 一种西洛他唑的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| JPS5645414A (en) | 1979-09-19 | 1981-04-25 | Otsuka Pharmaceut Co Ltd | Phosphodiesterase inhibitor |
| JPS5646810A (en) | 1979-09-25 | 1981-04-28 | Otsuka Pharmaceut Co Ltd | Blood platelet coagulation inhibitor |
| JPS5859980A (ja) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPS5877880A (ja) | 1981-11-05 | 1983-05-11 | Otsuka Pharmaceut Co Ltd | テトラゾ−ル誘導体 |
| JPS59157084A (ja) | 1983-02-28 | 1984-09-06 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPH01265051A (ja) * | 1988-04-14 | 1989-10-23 | Fuji Photo Film Co Ltd | ジアリールオキシアルカン製造方法 |
| KR100281593B1 (ko) | 1999-02-09 | 2001-02-15 | 류덕희 | 5-할로부틸-1-시클로헥실테트라졸의 제조방법 |
| US20030045547A1 (en) * | 2001-05-02 | 2003-03-06 | Shinji Aki | Process for producing carbostyril derivatives |
| JP4060523B2 (ja) * | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
| US6515128B2 (en) * | 2000-03-20 | 2003-02-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
| AU2001284887A1 (en) | 2000-08-14 | 2002-02-25 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
-
2003
- 2003-09-09 SI SI200331965T patent/SI1489080T1/sl unknown
- 2003-09-09 EP EP03788701A patent/EP1489080B1/de not_active Expired - Lifetime
- 2003-09-09 DK DK03788701.5T patent/DK1489080T3/da active
- 2003-09-09 KR KR1020047003418A patent/KR100551926B1/ko not_active Expired - Lifetime
- 2003-09-09 CN CNB038010089A patent/CN1257902C/zh not_active Expired - Fee Related
- 2003-09-09 PT PT03788701T patent/PT1489080E/pt unknown
- 2003-09-09 DE DE60335865T patent/DE60335865D1/de not_active Expired - Lifetime
- 2003-09-09 AT AT03788701T patent/ATE496907T1/de active
- 2003-09-09 WO PCT/JP2003/011515 patent/WO2004024716A1/ja not_active Ceased
- 2003-09-09 ES ES03788701T patent/ES2358324T3/es not_active Expired - Lifetime
- 2003-09-09 US US10/488,951 patent/US7026486B2/en not_active Expired - Fee Related
- 2003-09-10 JP JP2003318669A patent/JP4629322B2/ja not_active Expired - Lifetime
-
2011
- 2011-02-28 CY CY20111100236T patent/CY1111277T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1489080E (pt) | 2011-02-16 |
| WO2004024716A1 (ja) | 2004-03-25 |
| KR100551926B1 (ko) | 2006-02-17 |
| DE60335865D1 (de) | 2011-03-10 |
| JP4629322B2 (ja) | 2011-02-09 |
| ES2358324T3 (es) | 2011-05-09 |
| EP1489080A1 (de) | 2004-12-22 |
| JP2004123739A (ja) | 2004-04-22 |
| DK1489080T3 (da) | 2011-04-04 |
| CN1553908A (zh) | 2004-12-08 |
| US7026486B2 (en) | 2006-04-11 |
| EP1489080B1 (de) | 2011-01-26 |
| KR20040041605A (ko) | 2004-05-17 |
| SI1489080T1 (sl) | 2011-05-31 |
| US20040267020A1 (en) | 2004-12-30 |
| CY1111277T1 (el) | 2015-08-05 |
| CN1257902C (zh) | 2006-05-31 |
| EP1489080A4 (de) | 2006-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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