ATE531702T1 - Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafür - Google Patents
Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafürInfo
- Publication number
- ATE531702T1 ATE531702T1 AT03730869T AT03730869T ATE531702T1 AT E531702 T1 ATE531702 T1 AT E531702T1 AT 03730869 T AT03730869 T AT 03730869T AT 03730869 T AT03730869 T AT 03730869T AT E531702 T1 ATE531702 T1 AT E531702T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- intermediate products
- chem
- reacted
- base
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- RUZLIIJDZBWWSA-INIZCTEOSA-N methyl 2-[[(1s)-1-(7-methyl-2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1N[C@@H](C)C1=CC(C)=CN2C(=O)C=C(N3CCOCC3)N=C12 RUZLIIJDZBWWSA-INIZCTEOSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- YRYSAWZMIRQUBO-UHFFFAOYSA-N trimethylsulfoxonium Chemical class C[S+](C)(C)=O YRYSAWZMIRQUBO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002180610 | 2002-06-20 | ||
| JP2002313317 | 2002-10-28 | ||
| JP2002318833 | 2002-10-31 | ||
| PCT/JP2003/007316 WO2004000826A1 (ja) | 2002-06-20 | 2003-06-10 | エポキシトリアゾール誘導体およびその中間体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE531702T1 true ATE531702T1 (de) | 2011-11-15 |
Family
ID=29740560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03730869T ATE531702T1 (de) | 2002-06-20 | 2003-06-10 | Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafür |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6884892B2 (de) |
| EP (1) | EP1535914B1 (de) |
| JP (1) | JP4336648B2 (de) |
| KR (1) | KR100984653B1 (de) |
| CN (1) | CN1298711C (de) |
| AT (1) | ATE531702T1 (de) |
| AU (1) | AU2003242144A1 (de) |
| CA (1) | CA2489611C (de) |
| ES (1) | ES2372275T3 (de) |
| WO (1) | WO2004000826A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004032543D1 (de) * | 2003-07-18 | 2011-06-16 | Kaneka Corp | Optisch aktives halogenhydrinderivat und verfahren zur herstellung eines optisch aktiven epoxyalkoholderivats davon |
| JP4651969B2 (ja) * | 2004-04-28 | 2011-03-16 | 株式会社カネカ | エポキシトリアゾール化合物の製造方法 |
| EP1930313A3 (de) * | 2004-07-08 | 2008-11-19 | Ciba Holding Inc. | Herstellung von Alphaaminoketonen |
| WO2006059759A1 (ja) * | 2004-11-30 | 2006-06-08 | Sumitomo Chemical Company, Limited | エポキシトリアゾール誘導体の製造方法 |
| JP2006182765A (ja) * | 2004-11-30 | 2006-07-13 | Sumitomo Chemical Co Ltd | エポキシトリアゾール誘導体の製造方法 |
| PL1954264T3 (pl) * | 2005-12-01 | 2010-02-26 | Basilea Pharmaceutica Ag | Sposób wytwarzania epoksybutanolowych związków pośrednich |
| JP4278669B2 (ja) * | 2006-08-17 | 2009-06-17 | 住友化学株式会社 | エポキシ化合物の精製方法 |
| ATE490320T1 (de) * | 2006-12-13 | 2010-12-15 | Hoffmann La Roche | Verwendung von acetalen zur isolation von nukleinsäuren |
| JP5054397B2 (ja) * | 2007-03-12 | 2012-10-24 | 住友化学株式会社 | エポキシトリアゾール誘導体またはその塩の製造方法 |
| JP5654738B2 (ja) * | 2008-08-08 | 2015-01-14 | 株式会社カネカ | エポキシトリアゾール誘導体の製造法 |
| US8207352B2 (en) * | 2009-10-08 | 2012-06-26 | Drug Process Licensing Associates LLC | Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole |
| WO2015150947A1 (en) * | 2014-03-29 | 2015-10-08 | Wockhardt Limited | A process for the preparation of isavuconazole and its intermediates |
| CN106795097A (zh) * | 2014-10-03 | 2017-05-31 | 普拉克生化公司 | N,n‑二烷基乳酰胺的生产方法 |
| TWI637948B (zh) * | 2015-11-17 | 2018-10-11 | 維愛美製藥公司 | 製備４－（（６－（２－（２，４－二氟苯基）－１，１－二氟－２－羥基－３－（１ｈ－１，２，４－三唑－１－基）丙基）吡啶－３－基）氧基）苄腈之方法 |
| WO2017087643A1 (en) * | 2015-11-17 | 2017-05-26 | Viamet Pharmaceuticals, Inc. | 4-((6-2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| US10730861B2 (en) | 2017-08-10 | 2020-08-04 | Sumitomo Chemical Company, Limited | Process for producing epoxy alcohol compound |
| CN115856144B (zh) * | 2022-12-19 | 2023-07-07 | 华夏生生药业(北京)有限公司 | 一种氟康唑原料药及注射液中三甲基碘化亚砜杂质的检测方法 |
| CN116589447A (zh) * | 2023-04-28 | 2023-08-15 | 浙江工业大学 | 一种艾氟康唑的化学-酶工艺合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3442912A (en) * | 1965-09-23 | 1969-05-06 | Dow Chemical Co | Synthesis of aromatic epoxides from trialkylsulfonium salts |
| EP0061835B1 (de) | 1981-03-18 | 1989-02-01 | Imperial Chemical Industries Plc | Triazolverbindungen, Verfahren zu deren Herstellung, deren Anwendung als Pflanzenfungizide und deren fungizide Zusammensetzungen |
| NZ235102A (en) | 1989-09-01 | 1993-05-26 | Schering Corp | Asymmetric chemical synthesis and intermediates for making antifungal compounds |
| IE903395A1 (en) | 1989-09-26 | 1991-04-10 | Takeda Chemical Industries Ltd | Triazole compounds, their production and use |
| JPH04356471A (ja) | 1991-03-25 | 1992-12-10 | Takeda Chem Ind Ltd | トリアゾール化合物およびその用途 |
| TW297813B (de) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd | |
| AU4675596A (en) * | 1995-02-17 | 1996-09-04 | Takeda Chemical Industries Ltd. | Azole compounds, their production and use |
-
2002
- 2002-12-31 US US10/335,400 patent/US6884892B2/en not_active Expired - Lifetime
-
2003
- 2003-06-10 WO PCT/JP2003/007316 patent/WO2004000826A1/ja not_active Ceased
- 2003-06-10 CN CNB038144506A patent/CN1298711C/zh not_active Expired - Lifetime
- 2003-06-10 KR KR1020047020723A patent/KR100984653B1/ko not_active Expired - Lifetime
- 2003-06-10 AU AU2003242144A patent/AU2003242144A1/en not_active Abandoned
- 2003-06-10 AT AT03730869T patent/ATE531702T1/de active
- 2003-06-10 ES ES03730869T patent/ES2372275T3/es not_active Expired - Lifetime
- 2003-06-10 JP JP2004515483A patent/JP4336648B2/ja not_active Expired - Lifetime
- 2003-06-10 EP EP03730869A patent/EP1535914B1/de not_active Expired - Lifetime
- 2003-06-10 CA CA2489611A patent/CA2489611C/en not_active Expired - Fee Related
-
2004
- 2004-05-10 US US10/842,600 patent/US7297802B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2004000826A1 (ja) | 2005-10-20 |
| CN1662518A (zh) | 2005-08-31 |
| ES2372275T3 (es) | 2012-01-17 |
| EP1535914B1 (de) | 2011-11-02 |
| CN1298711C (zh) | 2007-02-07 |
| CA2489611A1 (en) | 2003-12-31 |
| AU2003242144A8 (en) | 2004-01-06 |
| CA2489611C (en) | 2011-06-14 |
| WO2004000826A8 (ja) | 2004-10-28 |
| US20030236419A1 (en) | 2003-12-25 |
| KR20050019764A (ko) | 2005-03-03 |
| US20040267024A1 (en) | 2004-12-30 |
| AU2003242144A1 (en) | 2004-01-06 |
| EP1535914A4 (de) | 2006-05-24 |
| WO2004000826A1 (ja) | 2003-12-31 |
| US7297802B2 (en) | 2007-11-20 |
| JP4336648B2 (ja) | 2009-09-30 |
| US6884892B2 (en) | 2005-04-26 |
| EP1535914A1 (de) | 2005-06-01 |
| KR100984653B1 (ko) | 2010-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE531702T1 (de) | Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafür | |
| EP1277752A4 (de) | Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten | |
| EA200900817A1 (ru) | Способ получения фторметилзамещённых гетероциклических соединений | |
| ATE202087T1 (de) | Verfahren zur herstellung von 4-substituierten azetidinon-derivaten | |
| ATE442363T1 (de) | Verfahren zur herstellung von pyridinverbindungen | |
| ATE477227T1 (de) | Verfahren zur herstellung eines trans-4-amino-1- cyclohexancarbonsäurederivats | |
| ATE343385T1 (de) | Verfahren zur herstellung von donepezil | |
| ATE496907T1 (de) | Verfahren zur herstellung von cilostazol | |
| DE60233754D1 (de) | Biotinzwischenprodukt und verfahren zu dessen herstellung | |
| EP1787983A4 (de) | Verfahren zur herstellung von isoindolderivaten | |
| EP1693358A4 (de) | Verfahren zur herstellung einer epoxytriazolverbindung und zwischenprodukt dafür | |
| MXPA05009338A (es) | 7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen. | |
| EA200700767A1 (ru) | Способ получения пиразолов | |
| ATE157971T1 (de) | Verfahren zur herstellung von aminotriazin- derivaten | |
| ATE311382T1 (de) | Verfahren zur herstellung von 2-carbamoyl- pyridinen | |
| DE60333950D1 (de) | Verfahren zur herstellung von benzylaminderivaten | |
| ATE189453T1 (de) | Verfahren zur herstellung von 2-cyanobiphenyl- verbindungen | |
| ATE553081T1 (de) | Verfahren zur herstellung einer bakteriziden pyridinverbindung, und bakterizide pyridinverbindung | |
| ATE373631T1 (de) | Verfahren zur herstellung von 1-chlor-4-arylbutan | |
| ATE299498T1 (de) | Verfahren zur herstellung von imidazolderivaten | |
| ATE407118T1 (de) | Verfahren zur herstellung von n-alkoxycarbonyl- piperidin derivaten sowie zwischenverbindungen dafür | |
| ATE260264T1 (de) | Verfahren zur herstellung von oxazol-derivaten | |
| ATE506349T1 (de) | Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat | |
| ATE223377T1 (de) | Verfahren zur herstellung von difluoracetophenon- derivaten | |
| DE60009893D1 (de) | Benzoxazol-derivate, verfahren zu ihrer herstellung und herbizide |