CY1111277T1 - Μεθοδος παραγωγης κιλοσταζολης - Google Patents
Μεθοδος παραγωγης κιλοσταζοληςInfo
- Publication number
- CY1111277T1 CY1111277T1 CY20111100236T CY111100236T CY1111277T1 CY 1111277 T1 CY1111277 T1 CY 1111277T1 CY 20111100236 T CY20111100236 T CY 20111100236T CY 111100236 T CY111100236 T CY 111100236T CY 1111277 T1 CY1111277 T1 CY 1111277T1
- Authority
- CY
- Cyprus
- Prior art keywords
- äiiü
- kilostazol
- carbostyril derivative
- derivative
- production method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Η παρούσα ευρεσιτεχνία παρέχει μέθοδο παραγωγής κιλοσταζόλης (I) με υψηλή απόδοση και σε υψηλή καθαρότητα, δι' αντιδράσεως παραγώγου καρβοστυρυλίου (II) με παράγωγο τετραζολίου (III) παρουσία ενώσεως ανοργάνου βάσεως εντός νερού ως διαλύτη, όπου το νερό χρησιμοποιείται σε ποσότητα, κατά βάρος, 3 έως 7 φορές μεγαλύτερη από εκείνη του παραγώγου καρβοστυρυλίου (II), και η ένωση ανοργάνου βάσεως χρησιμοποιείται σε ποσότητα από 1 mole έως 6 mole ανά mole παραγώγου καρβοστυρυλίου (II). Η μέθοδος της παρούσας ευρεσιτεχνίας είναι η βελτιωμένη και φιλική προς το περιβάλλον μέθοδος παραγωγής κιλοσταζόλης χρήσιμης για φαρμακευτικές ουσίες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002264314 | 2002-09-10 | ||
EP03788701A EP1489080B1 (en) | 2002-09-10 | 2003-09-09 | Process for producing cilostazol |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111277T1 true CY1111277T1 (el) | 2015-08-05 |
Family
ID=31986513
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100236T CY1111277T1 (el) | 2002-09-10 | 2011-02-28 | Μεθοδος παραγωγης κιλοσταζολης |
Country Status (13)
Country | Link |
---|---|
US (1) | US7026486B2 (el) |
EP (1) | EP1489080B1 (el) |
JP (1) | JP4629322B2 (el) |
KR (1) | KR100551926B1 (el) |
CN (1) | CN1257902C (el) |
AT (1) | ATE496907T1 (el) |
CY (1) | CY1111277T1 (el) |
DE (1) | DE60335865D1 (el) |
DK (1) | DK1489080T3 (el) |
ES (1) | ES2358324T3 (el) |
PT (1) | PT1489080E (el) |
SI (1) | SI1489080T1 (el) |
WO (1) | WO2004024716A1 (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
US20050101631A1 (en) * | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
IL167483A (en) * | 2004-03-16 | 2011-04-28 | Chemagis Ltd | Process for obtaining highly pure cilostazol |
WO2005123033A2 (en) * | 2004-06-18 | 2005-12-29 | Ranbaxy Laboratories Limited | Fine particles of cilostazol and processes for production thereof |
KR100633232B1 (ko) * | 2004-08-25 | 2006-10-11 | 주식회사유한양행 | 신규한 6-[4-(1-시클로헥실-1h-테트라졸-5-일)부톡시]-3,4-디히드로-2(1h)-퀴놀리논 정제방법 |
US20080075785A1 (en) * | 2006-09-22 | 2008-03-27 | San-Laung Chow | Controlled release hydrogel formulation |
US20110165236A1 (en) * | 2006-09-22 | 2011-07-07 | Biokey, Inc. | Controlled release hydrogel formulation |
CN101434598B (zh) * | 2008-12-19 | 2012-11-07 | 重庆康乐制药有限公司 | 西洛他唑的制备方法 |
CN102086190B (zh) * | 2011-01-28 | 2013-07-10 | 海南美兰史克制药有限公司 | 西洛他唑化合物及其制法 |
CN107382970A (zh) * | 2017-07-26 | 2017-11-24 | 浙江金立源药业有限公司 | 一种西洛他唑的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5645414A (en) | 1979-09-19 | 1981-04-25 | Otsuka Pharmaceut Co Ltd | Phosphodiesterase inhibitor |
JPS5646810A (en) | 1979-09-25 | 1981-04-28 | Otsuka Pharmaceut Co Ltd | Blood platelet coagulation inhibitor |
JPS5859980A (ja) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JPS5877880A (ja) | 1981-11-05 | 1983-05-11 | Otsuka Pharmaceut Co Ltd | テトラゾ−ル誘導体 |
JPS59157084A (ja) | 1983-02-28 | 1984-09-06 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JPH01265051A (ja) * | 1988-04-14 | 1989-10-23 | Fuji Photo Film Co Ltd | ジアリールオキシアルカン製造方法 |
KR100281593B1 (ko) | 1999-02-09 | 2001-02-15 | 류덕희 | 5-할로부틸-1-시클로헥실테트라졸의 제조방법 |
JP4060523B2 (ja) * | 1999-11-24 | 2008-03-12 | 大塚製薬株式会社 | カルボスチリル誘導体の製造法 |
US20030045547A1 (en) * | 2001-05-02 | 2003-03-06 | Shinji Aki | Process for producing carbostyril derivatives |
US6515128B2 (en) * | 2000-03-20 | 2003-02-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
AU2001284887A1 (en) * | 2000-08-14 | 2002-02-25 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
-
2003
- 2003-09-09 CN CNB038010089A patent/CN1257902C/zh not_active Expired - Fee Related
- 2003-09-09 DK DK03788701.5T patent/DK1489080T3/da active
- 2003-09-09 AT AT03788701T patent/ATE496907T1/de active
- 2003-09-09 WO PCT/JP2003/011515 patent/WO2004024716A1/ja active Application Filing
- 2003-09-09 PT PT03788701T patent/PT1489080E/pt unknown
- 2003-09-09 SI SI200331965T patent/SI1489080T1/sl unknown
- 2003-09-09 DE DE60335865T patent/DE60335865D1/de not_active Expired - Lifetime
- 2003-09-09 US US10/488,951 patent/US7026486B2/en not_active Expired - Fee Related
- 2003-09-09 KR KR1020047003418A patent/KR100551926B1/ko active IP Right Grant
- 2003-09-09 EP EP03788701A patent/EP1489080B1/en not_active Expired - Lifetime
- 2003-09-09 ES ES03788701T patent/ES2358324T3/es not_active Expired - Lifetime
- 2003-09-10 JP JP2003318669A patent/JP4629322B2/ja not_active Expired - Lifetime
-
2011
- 2011-02-28 CY CY20111100236T patent/CY1111277T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1489080E (pt) | 2011-02-16 |
JP2004123739A (ja) | 2004-04-22 |
CN1257902C (zh) | 2006-05-31 |
WO2004024716A1 (ja) | 2004-03-25 |
DE60335865D1 (de) | 2011-03-10 |
EP1489080A4 (en) | 2006-02-15 |
KR100551926B1 (ko) | 2006-02-17 |
US20040267020A1 (en) | 2004-12-30 |
DK1489080T3 (da) | 2011-04-04 |
JP4629322B2 (ja) | 2011-02-09 |
CN1553908A (zh) | 2004-12-08 |
SI1489080T1 (sl) | 2011-05-31 |
ATE496907T1 (de) | 2011-02-15 |
US7026486B2 (en) | 2006-04-11 |
EP1489080A1 (en) | 2004-12-22 |
ES2358324T3 (es) | 2011-05-09 |
KR20040041605A (ko) | 2004-05-17 |
EP1489080B1 (en) | 2011-01-26 |
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