HK1081966A1 - Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide - Google Patents

Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

Info

Publication number
HK1081966A1
HK1081966A1 HK06102356A HK06102356A HK1081966A1 HK 1081966 A1 HK1081966 A1 HK 1081966A1 HK 06102356 A HK06102356 A HK 06102356A HK 06102356 A HK06102356 A HK 06102356A HK 1081966 A1 HK1081966 A1 HK 1081966A1
Authority
HK
Hong Kong
Prior art keywords
piperazin
acetamide
dimethyl
phenyl
production
Prior art date
Application number
HK06102356A
Other languages
English (en)
Inventor
Michel Joseph Maurice Andre Guillaume
Jozef Ludo Jan Cuypers
Ivan Joseph Maria Vervest
Stefan Marcel Herman Leurs
Dirk De Smaele
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29797257&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1081966(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1081966A1 publication Critical patent/HK1081966A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK06102356A 2002-06-24 2006-02-22 Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide HK1081966A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02077749 2002-06-24
PCT/EP2003/050241 WO2004000824A1 (en) 2002-06-24 2003-06-19 Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

Publications (1)

Publication Number Publication Date
HK1081966A1 true HK1081966A1 (en) 2006-05-26

Family

ID=29797257

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06102356A HK1081966A1 (en) 2002-06-24 2006-02-22 Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

Country Status (13)

Country Link
US (1) US8541578B2 (xx)
EP (1) EP1517900B1 (xx)
JP (1) JP4846234B2 (xx)
CN (1) CN1326846C (xx)
AT (1) ATE432267T1 (xx)
AU (1) AU2003255511B2 (xx)
BR (1) BRPI0312001B1 (xx)
CA (1) CA2487141C (xx)
DE (1) DE60327765D1 (xx)
ES (1) ES2326800T3 (xx)
HK (1) HK1081966A1 (xx)
IL (1) IL165916A (xx)
WO (1) WO2004000824A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747294B (zh) * 2008-12-10 2011-09-28 上海医药工业研究院 一种n-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺的纯化方法
EP3782992A1 (en) 2015-03-10 2021-02-24 Unichem Laboratories Limited Novel process for the preparation of ranolazine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US458129A (en) * 1891-08-18 papin
GB840358A (en) 1957-10-11 1960-07-06 British Drug Houses Ltd Improvements in or relating to the manufacture of n-mono-substituted piperazines
US3953448A (en) * 1972-12-07 1976-04-27 Delmar Chemicals Limited Piperazino-anilido compounds
IT1054961B (it) 1976-01-23 1981-11-30 Corvi Camillo Spa Derivati della piperazina adatti come agenti anti ulcera
US4567264A (en) 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4558129A (en) * 1983-05-18 1985-12-10 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
CA2101311A1 (en) * 1992-07-31 1994-02-01 Neelakantan Balasubramanian Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
JPH10504324A (ja) * 1995-06-07 1998-04-28 デイド、ケミストリー、システムズ、インコーポレイテッド 薬物の免疫原その他の接合体の製造
NZ321575A (en) 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

Also Published As

Publication number Publication date
EP1517900A1 (en) 2005-03-30
US20050240018A1 (en) 2005-10-27
CN1662517A (zh) 2005-08-31
AU2003255511B2 (en) 2009-02-05
AU2003255511A1 (en) 2004-01-06
IL165916A0 (en) 2006-01-15
CA2487141C (en) 2011-08-02
DE60327765D1 (de) 2009-07-09
ES2326800T3 (es) 2009-10-20
ATE432267T1 (de) 2009-06-15
JP2005530837A (ja) 2005-10-13
US8541578B2 (en) 2013-09-24
IL165916A (en) 2012-12-31
JP4846234B2 (ja) 2011-12-28
WO2004000824A1 (en) 2003-12-31
EP1517900B1 (en) 2009-05-27
CA2487141A1 (en) 2003-12-31
BRPI0312001B1 (pt) 2015-04-07
BR0312001A (pt) 2005-03-22
CN1326846C (zh) 2007-07-18

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230618