MX9803407A - Derivados de piperazina 1-(1,2-disustituido piperidinil)-4-sustituidos. - Google Patents

Derivados de piperazina 1-(1,2-disustituido piperidinil)-4-sustituidos.

Info

Publication number
MX9803407A
MX9803407A MX9803407A MX9803407A MX9803407A MX 9803407 A MX9803407 A MX 9803407A MX 9803407 A MX9803407 A MX 9803407A MX 9803407 A MX9803407 A MX 9803407A MX 9803407 A MX9803407 A MX 9803407A
Authority
MX
Mexico
Prior art keywords
6alkyl
6alkenyl
formula
substituted
6alkyloxy
Prior art date
Application number
MX9803407A
Other languages
English (en)
Inventor
Frans Eduard Janssens
Francois Maria Sommen
Louis Nestor Ghislai Dominique
Joseph Elisabeth Leenaerts
Yves Emiel M Van Roosbroeck
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8220780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9803407(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX9803407A publication Critical patent/MX9803407A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Esta invencion se relaciona con los compuestos de la formula (Ver Formula) en las formas N-oxido, las sales de adicion farmacéuticamente aceptables y las formas estereosioméricas de los mismos, en los cuales n es 0, 1 o 2, siempre que si m es 2, luego n sea 1; p es 1 o 2; =Q es =O o =NR2; X es un enlace covalente o un radical bivalente de la formula -O-, -S-, NR3; R1 es Ar1, Ar1C1-6alquilo o di(Ar1)C1-6alquilo, donde cada grupo alquilo C1-6 es optativamente substituido con hidroxi, alquiloxi C1-4, oxo o un substituyente oxo catalizado; R2 es Ar2, Ar2C1-6alquilo, Het1 o Het1C1-6alquilo; R3 es hidrogeno o alquilo C1-6; L es hidrogeno; Ar3; alquilo C1-6; alquilo C1-6 substituido con 1 o 2 substituyentes seleccionados entre hidroxi, alquiloxi C1-6; Ar3C1-6alquiloxi y Het2; alquenilo C3-6; Ar3, Ar3C1-6alquenilo; di(Ar3)C3-6alquenilo o un radical de la formula (a-1), (a-2), (a-3), (a-4) o (a-5); cada uno de Ar1, Ar2 y Ar3 es fenilo o fenilo substituido; cada uno de Het1 y Het2 es un hetrocíclico monocíclico o bicíclico; como antagonistas de la substancia P; su preparacion, las composiciones que los contienen y su uso como medicamento.
MX9803407A 1995-10-30 1998-04-29 Derivados de piperazina 1-(1,2-disustituido piperidinil)-4-sustituidos. MX9803407A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95202929 1995-10-30

Publications (1)

Publication Number Publication Date
MX9803407A true MX9803407A (es) 1998-09-30

Family

ID=8220780

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803407A MX9803407A (es) 1995-10-30 1998-04-29 Derivados de piperazina 1-(1,2-disustituido piperidinil)-4-sustituidos.

Country Status (31)

Country Link
US (3) US6197772B1 (es)
EP (1) EP0862566B1 (es)
JP (1) JP3073238B2 (es)
KR (1) KR100407067B1 (es)
CN (2) CN1117744C (es)
AR (1) AR004698A1 (es)
AT (1) ATE188691T1 (es)
AU (1) AU704155B2 (es)
BR (1) BR9611184B8 (es)
CA (1) CA2234096C (es)
CY (1) CY2177B1 (es)
CZ (1) CZ291794B6 (es)
DE (1) DE69606196T2 (es)
DK (1) DK0862566T3 (es)
EA (1) EA000909B1 (es)
ES (1) ES2143238T3 (es)
GR (1) GR3033154T3 (es)
HR (1) HRP960507B1 (es)
HU (1) HU227341B1 (es)
IL (1) IL123962A (es)
MX (1) MX9803407A (es)
MY (1) MY116575A (es)
NO (1) NO310232B1 (es)
NZ (1) NZ321575A (es)
PL (1) PL185029B1 (es)
PT (1) PT862566E (es)
SI (1) SI0862566T1 (es)
TR (1) TR199800756T2 (es)
TW (1) TW460473B (es)
WO (1) WO1997016440A1 (es)
ZA (1) ZA969090B (es)

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Also Published As

Publication number Publication date
CN100415716C (zh) 2008-09-03
AU7493296A (en) 1997-05-22
AR004698A1 (es) 1999-03-10
CZ132298A3 (cs) 1998-09-16
USRE37886E1 (en) 2002-10-15
CN1205699A (zh) 1999-01-20
TW460473B (en) 2001-10-21
CN1117744C (zh) 2003-08-13
ATE188691T1 (de) 2000-01-15
CN1438220A (zh) 2003-08-27
PT862566E (pt) 2000-06-30
US6521621B1 (en) 2003-02-18
CA2234096A1 (en) 1997-05-09
HRP960507A2 (en) 1998-02-28
BR9611184B8 (pt) 2015-02-18
CZ291794B6 (cs) 2003-05-14
TR199800756T2 (xx) 1998-07-21
CA2234096C (en) 2005-06-14
NO310232B1 (no) 2001-06-11
SI0862566T1 (en) 2000-04-30
WO1997016440A1 (en) 1997-05-09
HRP960507B1 (en) 2001-08-31
BR9611184A (pt) 1999-03-30
PL185029B1 (pl) 2003-02-28
EP0862566A1 (en) 1998-09-09
PL327406A1 (en) 1998-12-07
KR100407067B1 (ko) 2004-06-04
MY116575A (en) 2004-02-28
US6197772B1 (en) 2001-03-06
DE69606196T2 (de) 2000-09-21
JP3073238B2 (ja) 2000-08-07
DE69606196D1 (de) 2000-02-17
EA000909B1 (ru) 2000-06-26
HUP9802985A3 (en) 2002-10-28
NO981534L (no) 1998-06-24
DK0862566T3 (da) 2000-06-13
JPH11514634A (ja) 1999-12-14
CY2177B1 (en) 2002-08-23
AU704155B2 (en) 1999-04-15
ES2143238T3 (es) 2000-05-01
HU227341B1 (en) 2011-04-28
IL123962A (en) 2001-01-11
ZA969090B (en) 1998-04-29
EA199800404A1 (ru) 1998-10-29
EP0862566B1 (en) 2000-01-12
NZ321575A (en) 1999-05-28
GR3033154T3 (en) 2000-08-31
KR19990064178A (ko) 1999-07-26
HUP9802985A2 (hu) 1999-10-28
NO981534D0 (no) 1998-04-03

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