ATE478075T1 - Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten - Google Patents
Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonistenInfo
- Publication number
- ATE478075T1 ATE478075T1 AT06708639T AT06708639T ATE478075T1 AT E478075 T1 ATE478075 T1 AT E478075T1 AT 06708639 T AT06708639 T AT 06708639T AT 06708639 T AT06708639 T AT 06708639T AT E478075 T1 ATE478075 T1 AT E478075T1
- Authority
- AT
- Austria
- Prior art keywords
- antagonistic activity
- neurokinin
- pain
- nonanderivatives
- diazaspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05101786 | 2005-03-08 | ||
PCT/EP2006/060458 WO2006094948A1 (en) | 2005-03-08 | 2006-03-03 | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE478075T1 true ATE478075T1 (de) | 2010-09-15 |
Family
ID=34938928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06708639T ATE478075T1 (de) | 2005-03-08 | 2006-03-03 | Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten |
Country Status (15)
Country | Link |
---|---|
US (1) | US8604200B2 (de) |
EP (1) | EP1858896B1 (de) |
JP (1) | JP5078869B2 (de) |
KR (1) | KR101388453B1 (de) |
CN (1) | CN101137657B (de) |
AT (1) | ATE478075T1 (de) |
AU (1) | AU2006221984C1 (de) |
BR (1) | BRPI0608847A2 (de) |
CA (1) | CA2599186C (de) |
DE (1) | DE602006016244D1 (de) |
EA (1) | EA014239B1 (de) |
ES (1) | ES2350647T3 (de) |
MX (1) | MX2007011079A (de) |
NZ (1) | NZ556628A (de) |
WO (1) | WO2006094948A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102070640A (zh) * | 2009-11-24 | 2011-05-25 | 上海药明康德新药开发有限公司 | 一种1,7-二氮杂螺[4,5]壬烷及其衍生物的合成方法 |
US9446029B2 (en) * | 2010-07-27 | 2016-09-20 | Colorado State University Research Foundation | Use of NK-1 receptor antagonists in management of visceral pain |
EP2484674A1 (de) | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro-Aminoverbindungen mit NK1-Antagonistenaktivität |
CN110730662A (zh) * | 2017-04-10 | 2020-01-24 | 才思治疗公司 | 用于治疗共核蛋白病的nk1-拮抗剂组合和方法 |
Family Cites Families (68)
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US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
HUT36793A (en) | 1983-06-27 | 1985-10-28 | Sandoz Ag | Process for producing new spirosuccunimide derivatives and pharmaceutical composition containing them |
PH23995A (en) | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
US4588722A (en) | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
CA1327579C (en) | 1986-02-03 | 1994-03-08 | Frans Eduard Janssens | Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines |
NZ223654A (en) | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
US5403593A (en) | 1991-03-04 | 1995-04-04 | Sandoz Ltd. | Melt granulated compositions for preparing sustained release dosage forms |
FR2676055B1 (fr) | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
GB9109862D0 (en) | 1991-05-08 | 1991-07-03 | Beecham Lab Sa | Pharmaceutical formulations |
IL101850A (en) | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
IL101851A (en) | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
MY110227A (en) | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
KR960011370B1 (ko) | 1991-12-31 | 1996-08-22 | 재단법인 한국화학연구소 | 스피로알킬아민 유도체와 그의 제조방법 |
WO1993014083A1 (en) | 1992-01-09 | 1993-07-22 | Janssen Pharmaceutica N.V. | Pharmaceutically active substituted benzimidazole derivatives |
AU693087B2 (en) | 1993-01-28 | 1998-06-25 | Merck & Co., Inc. | Spiro-substituted azacycles as tachykinin receptor antagonists |
US5635510A (en) | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
GB9310066D0 (en) | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Alkyl substituted heterocycles |
EP0702681A1 (de) | 1993-06-07 | 1996-03-27 | Merck & Co. Inc. | Spiro-substituierte azaringe als neurokinin antagonisten |
ATE198480T1 (de) | 1993-07-13 | 2001-01-15 | Janssen Pharmaceutica Nv | Antiallergische imidazoazepine |
AU7856194A (en) | 1993-10-26 | 1995-05-22 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
IL111730A (en) | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
GB2287404A (en) | 1994-03-15 | 1995-09-20 | Pfizer | Antiinflammatory and analgesic compositions |
PL180866B1 (pl) | 1994-07-12 | 2001-04-30 | Lilly Co Eli | Nowy trihydrat dichlorowodorku (R)-3-(1H-indol-3-ilo)-1-[N-(2-metoksybenzylo)acetyloamino]-2-[N-(2-(4-(piperydyn-1-ylo)piperydyn-1-ylo)acetylo)amino]propanu |
WO1996002503A1 (fr) | 1994-07-15 | 1996-02-01 | Meiji Seika Kabushiki Kaisha | Nouveaux composes ayant un effet inhibant l'agregation plaquettaire |
GB9415996D0 (en) | 1994-08-08 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
HUT77318A (hu) | 1994-09-30 | 1998-03-30 | Novartis Ag. | 1-Acil-4-/(alifás amino)-piperidin/-származékok, e vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk |
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JP3192631B2 (ja) | 1997-05-28 | 2001-07-30 | 三共株式会社 | 飽和複素環化合物からなる医薬 |
GB9714129D0 (en) | 1997-07-04 | 1997-09-10 | Pfizer Ltd | Azetidines |
US5997464A (en) | 1997-08-29 | 1999-12-07 | Orthosoft, L.L.C. | Magnetic coil for pulsed electromagnetic field |
WO1999011261A1 (en) | 1997-08-29 | 1999-03-11 | Dsm N.V. | Granules free of excipients |
GB9723544D0 (en) | 1997-11-07 | 1998-01-07 | Merck Sharp & Dohme | Therapeutic agents |
WO1999032489A1 (en) | 1997-12-23 | 1999-07-01 | Alcon Laboratories, Inc. | Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions |
PT1057827E (pt) * | 1998-01-23 | 2003-11-28 | Sankyo Co | Derivados da espiropiperidina |
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WO2001030348A1 (en) | 1999-10-25 | 2001-05-03 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
US6759520B1 (en) | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
US6482829B2 (en) | 2000-06-08 | 2002-11-19 | Hoffmann-La Roche Inc. | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor |
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GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
US6642226B2 (en) | 2001-02-06 | 2003-11-04 | Hoffman-La Roche Inc. | Substituted phenyl-piperidine methanone compounds |
BR0209127A (pt) | 2001-04-18 | 2006-03-21 | Euro Celtique Sa | compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos |
DK1390372T3 (da) | 2001-05-14 | 2008-09-15 | Hoffmann La Roche | 1-oxa-3,9-diaza-spiro '5,5]undecan-2-on-derivater og anvendelse deraf som neurokininreceptorantagonist |
CN101050215A (zh) | 2001-12-28 | 2007-10-10 | 阿卡蒂亚药品公司 | 作为单胺受体调节剂的螺氮杂环化合物 |
GB0203020D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
WO2004056772A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists |
MY141736A (en) | 2002-10-08 | 2010-06-15 | Elanco Animal Health Ireland | Substituted 1,4-di-piperidin-4-yi-piperazine derivatives and their use as neurokinin antagonists |
JO2485B1 (en) | 2002-12-23 | 2009-01-20 | شركة جانسين فارماسوتيكا ان. في | 1-Piperidine-3-Yl-4-Piperidine-4-Yl-Piperazine derivatives substituted and used as quinine antagonists |
DE60322110D1 (de) | 2002-12-23 | 2008-08-21 | Janssen Pharmaceutica Nv | Substituierte 4-(4-piperidin-yl-piperazin-1-yl)-azntagonisten |
JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
WO2004103305A2 (en) | 2003-05-16 | 2004-12-02 | Euroceltique S.A. | Spiropyrazole compound |
CN1822828A (zh) | 2003-06-10 | 2006-08-23 | 詹森药业有限公司 | 用于以阿片类药物为基础治疗疼痛的含取代的1,4-二哌啶-4-基哌嗪衍生物的新颖制剂 |
ES2307025T3 (es) | 2003-06-10 | 2008-11-16 | Janssen Pharmaceutica Nv | Combinacion de opioides y un derivado de la piperazina para el tratamiento del dolor. |
CA2579608A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
US7300505B2 (en) * | 2003-12-12 | 2007-11-27 | Canon Kabushiki Kaisha | Ink-jet recording ink, ink cartridge, recording unit, ink-jet recording method, ink-jet recording apparatus, and method for stabilizing ink ejection |
BRPI0507586A (pt) | 2004-02-10 | 2007-07-03 | Hoffmann La Roche | moduladores de receptor de quimiocina ccr5 |
JO2527B1 (en) * | 2004-04-06 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines |
JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
US7323415B2 (en) | 2004-04-23 | 2008-01-29 | Jsr Corporation | Polishing pad for semiconductor wafer, polishing multilayered body for semiconductor wafer having same, and method for polishing semiconductor wafer |
-
2006
- 2006-03-03 MX MX2007011079A patent/MX2007011079A/es active IP Right Grant
- 2006-03-03 EP EP06708639A patent/EP1858896B1/de active Active
- 2006-03-03 KR KR1020077020670A patent/KR101388453B1/ko not_active IP Right Cessation
- 2006-03-03 CN CN2006800073114A patent/CN101137657B/zh not_active Expired - Fee Related
- 2006-03-03 NZ NZ556628A patent/NZ556628A/en not_active IP Right Cessation
- 2006-03-03 BR BRPI0608847-3A patent/BRPI0608847A2/pt not_active IP Right Cessation
- 2006-03-03 AT AT06708639T patent/ATE478075T1/de not_active IP Right Cessation
- 2006-03-03 AU AU2006221984A patent/AU2006221984C1/en not_active Ceased
- 2006-03-03 WO PCT/EP2006/060458 patent/WO2006094948A1/en active Application Filing
- 2006-03-03 EA EA200701898A patent/EA014239B1/ru not_active IP Right Cessation
- 2006-03-03 JP JP2008500177A patent/JP5078869B2/ja not_active Expired - Fee Related
- 2006-03-03 CA CA2599186A patent/CA2599186C/en not_active Expired - Fee Related
- 2006-03-03 ES ES06708639T patent/ES2350647T3/es active Active
- 2006-03-03 US US11/886,175 patent/US8604200B2/en not_active Expired - Fee Related
- 2006-03-03 DE DE602006016244T patent/DE602006016244D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
JP2008532976A (ja) | 2008-08-21 |
EP1858896A1 (de) | 2007-11-28 |
EA014239B1 (ru) | 2010-10-29 |
CA2599186C (en) | 2014-12-09 |
EP1858896B1 (de) | 2010-08-18 |
BRPI0608847A2 (pt) | 2010-02-02 |
AU2006221984C1 (en) | 2012-02-09 |
CN101137657B (zh) | 2011-02-02 |
US8604200B2 (en) | 2013-12-10 |
CN101137657A (zh) | 2008-03-05 |
NZ556628A (en) | 2009-09-25 |
WO2006094948A1 (en) | 2006-09-14 |
KR20070108905A (ko) | 2007-11-13 |
DE602006016244D1 (de) | 2010-09-30 |
ES2350647T3 (es) | 2011-01-25 |
AU2006221984B2 (en) | 2011-04-21 |
JP5078869B2 (ja) | 2012-11-21 |
AU2006221984A1 (en) | 2006-09-14 |
EA200701898A1 (ru) | 2008-06-30 |
MX2007011079A (es) | 2007-10-08 |
KR101388453B1 (ko) | 2014-04-23 |
CA2599186A1 (en) | 2006-09-14 |
US20090221641A1 (en) | 2009-09-03 |
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