PT783490E - Compostos de 1-acil-4-alifatilaminopiperidina - Google Patents
Compostos de 1-acil-4-alifatilaminopiperidinaInfo
- Publication number
- PT783490E PT783490E PT95933394T PT95933394T PT783490E PT 783490 E PT783490 E PT 783490E PT 95933394 T PT95933394 T PT 95933394T PT 95933394 T PT95933394 T PT 95933394T PT 783490 E PT783490 E PT 783490E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- amino
- substituted
- alkylene
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH296694 | 1994-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT783490E true PT783490E (pt) | 2002-06-28 |
Family
ID=4245651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95933394T PT783490E (pt) | 1994-09-30 | 1995-09-19 | Compostos de 1-acil-4-alifatilaminopiperidina |
Country Status (14)
Country | Link |
---|---|
US (1) | US5935951A (pt) |
EP (1) | EP0783490B1 (pt) |
JP (1) | JPH10506399A (pt) |
AT (1) | ATE212981T1 (pt) |
AU (1) | AU3607895A (pt) |
CA (1) | CA2198382A1 (pt) |
DE (1) | DE69525355T2 (pt) |
DK (1) | DK0783490T3 (pt) |
ES (1) | ES2172595T3 (pt) |
FI (1) | FI971260A0 (pt) |
HU (1) | HUT77318A (pt) |
NO (1) | NO971383L (pt) |
PT (1) | PT783490E (pt) |
WO (1) | WO1996010562A1 (pt) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW475930B (en) * | 1995-04-24 | 2002-02-11 | Novartis Ag | Novel compound, its use and pharmaceutical composition comprising it |
NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
TW531537B (en) | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
TW429256B (en) * | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
DE10112198A1 (de) * | 2001-03-14 | 2002-09-19 | Gruenenthal Gmbh | Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine |
JP2005522436A (ja) | 2002-02-08 | 2005-07-28 | グラクソ グループ リミテッド | ピペリジルカルボキシアミド誘導体またはそのタキキニン介在疾患の治療における使用 |
GB0203020D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
GB0203022D0 (en) * | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
BRPI0608847A2 (pt) | 2005-03-08 | 2010-02-02 | Janssen Pharmaceutica Nv | derivados de diaza-espiro-[4,4]-nonano substituìdos e seu uso como antagonistas de neurocinina |
EP1888050B1 (en) | 2005-05-17 | 2012-03-21 | Merck Sharp & Dohme Ltd. | cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer |
AU2006270071B2 (en) | 2005-07-15 | 2012-02-02 | Albany Molecular Research, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
RU2008116844A (ru) | 2005-09-29 | 2009-11-10 | Мерк энд Ко., Инк. (US) | Ацилированные производные спиропиперидина как модуляторы рецептора меланокортина-4 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US20100179118A1 (en) * | 2006-09-08 | 2010-07-15 | Dainippon Sumitomo Pharma Co., Ltd. | Cyclic aminoalkylcarboxamide derivative |
EP2083831B1 (en) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
AU2008204380B2 (en) | 2007-01-10 | 2013-08-15 | Msd Italia S.R.L. | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors |
JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
EP3103791B1 (en) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
AU2009222122A1 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
WO2010123919A2 (en) * | 2009-04-20 | 2010-10-28 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
CN102458123A (zh) | 2009-05-12 | 2012-05-16 | 阿尔巴尼分子研究公司 | 芳基、杂芳基和杂环取代的四氢异喹啉及其用途 |
US8815894B2 (en) | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
EA020553B1 (ru) | 2009-05-12 | 2014-12-30 | Олбани Молекьюлар Рисерч, Инк. | 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ |
CN104945382B (zh) | 2009-10-14 | 2020-02-07 | 默沙东公司 | 提高p53活性的取代的哌啶和其用途 |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
JP6043285B2 (ja) | 2010-08-02 | 2016-12-14 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
LT2606134T (lt) | 2010-08-17 | 2019-07-25 | Sirna Therapeutics, Inc. | Hepatito b viruso (hbv) geno raiškos slopinimas, tarpininkaujant rnr interferencijai naudojant mažą interferuojančią nukleorūgštį (sina) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | 胰岛素样生长因子-1受体抑制剂 |
US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
EP2900241B1 (en) | 2012-09-28 | 2018-08-08 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
PT2925888T (pt) | 2012-11-28 | 2017-12-13 | Merck Sharp & Dohme | Composições e métodos para tratamento do cancro |
AU2013361694B2 (en) | 2012-12-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as HDM2 inhibitors |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2018071283A1 (en) | 2016-10-12 | 2018-04-19 | Merck Sharp & Dohme Corp. | Kdm5 inhibitors |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
CN111918647A (zh) | 2018-02-26 | 2020-11-10 | 圣拉斐尔医院有限公司 | 用于治疗眼痛的nk-1拮抗剂 |
EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
EP3833668A4 (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8804104D0 (en) * | 1988-02-23 | 1988-03-23 | Glaxo Group Ltd | Chemical compounds |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
DE69210029T2 (de) * | 1991-08-20 | 1997-01-09 | Merck Sharp & Dohme | Azacyclische verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
WO1995011895A1 (en) * | 1993-10-26 | 1995-05-04 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
-
1995
- 1995-09-19 AT AT95933394T patent/ATE212981T1/de not_active IP Right Cessation
- 1995-09-19 AU AU36078/95A patent/AU3607895A/en not_active Abandoned
- 1995-09-19 HU HU9701800A patent/HUT77318A/hu unknown
- 1995-09-19 EP EP95933394A patent/EP0783490B1/en not_active Expired - Lifetime
- 1995-09-19 CA CA002198382A patent/CA2198382A1/en not_active Abandoned
- 1995-09-19 DE DE69525355T patent/DE69525355T2/de not_active Expired - Fee Related
- 1995-09-19 ES ES95933394T patent/ES2172595T3/es not_active Expired - Lifetime
- 1995-09-19 WO PCT/EP1995/003681 patent/WO1996010562A1/en active IP Right Grant
- 1995-09-19 JP JP8511331A patent/JPH10506399A/ja not_active Ceased
- 1995-09-19 DK DK95933394T patent/DK0783490T3/da active
- 1995-09-19 PT PT95933394T patent/PT783490E/pt unknown
- 1995-09-19 US US08/809,277 patent/US5935951A/en not_active Expired - Fee Related
-
1997
- 1997-03-24 NO NO971383A patent/NO971383L/no unknown
- 1997-03-26 FI FI971260A patent/FI971260A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0783490A1 (en) | 1997-07-16 |
DK0783490T3 (da) | 2002-05-13 |
AU3607895A (en) | 1996-04-26 |
EP0783490B1 (en) | 2002-02-06 |
FI971260A (fi) | 1997-03-26 |
DE69525355D1 (de) | 2002-03-21 |
ES2172595T3 (es) | 2002-10-01 |
DE69525355T2 (de) | 2002-09-19 |
HUT77318A (hu) | 1998-03-30 |
JPH10506399A (ja) | 1998-06-23 |
NO971383L (no) | 1997-05-14 |
MX9702092A (es) | 1997-10-31 |
WO1996010562A1 (en) | 1996-04-11 |
CA2198382A1 (en) | 1996-04-11 |
US5935951A (en) | 1999-08-10 |
ATE212981T1 (de) | 2002-02-15 |
FI971260A0 (fi) | 1997-03-26 |
NO971383D0 (no) | 1997-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2172595T3 (es) | Compuestos de 1-acil-4-alifatilaminopiperidina. | |
ATE152719T1 (de) | Chinolylbenzofuran derivate als leukotrien- antagonisten | |
TW430664B (en) | Substituted carboxamidothiazoles, their preparation and pharmaceutical compositions containing them | |
ES2137998T3 (es) | Nuevos derivados de aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos. | |
ES8506001A1 (es) | Un procedimiento para preparar compuestos de imidazol fusionados | |
EA199900242A1 (ru) | Аралкил- и аралкилиден-гетероциклические лактамы и имиды | |
KR960013370A (ko) | 트리글리세리드 과다 방지 조성물 | |
CS621987A2 (en) | Coating composition | |
ATE181731T1 (de) | Isothioharnstoff-derivate als no synthase hemmer | |
MA23639A1 (fr) | Derives pyrrocarbazole, leur preparation, les compositions pharmaceutiques les contenant, leur utilisation dans le traitement des tumeurs malignes. | |
MX9306310A (es) | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
EA200300044A1 (ru) | Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции | |
FR2696466B1 (fr) | Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant. | |
IT1196423B (it) | Benzotiazolin-composti | |
FR2659653B1 (fr) | Derives de l'uree, leur preparation et les medicaments les contenant. | |
NZ218453A (en) | Pharmaceutical compositions containing a synergistic mixture of a dihydropyridine derivative and pyridazodiazepine derivative | |
ATE38987T1 (de) | Neue 2h-1-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten. | |
EA200000116A1 (ru) | Противогрибковые соединения на основе 2,4,4-тризамещенных-1,3-диоксоланов | |
MY118312A (en) | Angiogenesis inhibiting 5- substituted- 1,2,4- thiadiazolyl derivatives | |
BE896635A (fr) | Compositions pharmaceutiques analgesiques contenant des 5-phenyl-1,4-benzodiazepines. | |
DE3166645D1 (en) | Dibenzoxazonine, dibenzoxazecine, dibenzoxaazacycloundecane derivatives and their corresponding thia- and aza derivatives, their preparation and pharmaceutical compositions | |
ATE19629T1 (de) | N-substituierte derivate des tetrahydroisophthalimids. | |
IL106597A0 (en) | Androst-4-eno(4,5-b)pyrrole derivatives,their preparation and pharmaceutical compositions containing them | |
FI882421A (fi) | 5-fenyl-1,2,3a,4,5,9b-hexahydro-3h -benz(e)indol, deras framstaellning och anvaendning som laekemedel. | |
GB1115037A (en) | Improvements in or relating to indolylethylamines |