US3126375A
(en)
|
|
1964-03-24 |
|
Chioacyl |
US2789118A
(en)
|
1956-03-30 |
1957-04-16 |
American Cyanamid Co |
16-alpha oxy-belta1, 4-pregnadienes
|
US2990401A
(en)
|
1958-06-18 |
1961-06-27 |
American Cyanamid Co |
11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
|
US3048581A
(en)
|
1960-04-25 |
1962-08-07 |
Olin Mathieson |
Acetals and ketals of 16, 17-dihydroxy steroids
|
US3749712A
(en)
|
1970-09-25 |
1973-07-31 |
Sigma Tau Ind Farmaceuti |
Triamcinolone acetonide esters and process for their preparation
|
SE378109B
(lt)
|
1972-05-19 |
1975-08-18 |
Bofors Ab |
|
SE378110B
(lt)
|
1972-05-19 |
1975-08-18 |
Bofors Ab |
|
US3996359A
(en)
|
1972-05-19 |
1976-12-07 |
Ab Bofors |
Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
|
US4294926A
(en)
|
1979-06-15 |
1981-10-13 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
US4319039A
(en)
|
1979-06-15 |
1982-03-09 |
Merck & Co., Inc. |
Preparation of ammonium salt of hypocholesteremic fermentation product
|
US4444784A
(en)
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
DK149080C
(da)
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
JPS5889191A
(ja)
|
1981-11-20 |
1983-05-27 |
Sankyo Co Ltd |
3−ヒドロキシ−ml−236b誘導体の製造法
|
US5354772A
(en)
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
US4911165A
(en)
|
1983-01-12 |
1990-03-27 |
Ethicon, Inc. |
Pliabilized polypropylene surgical filaments
|
US4681893A
(en)
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
US4885314A
(en)
|
1987-06-29 |
1989-12-05 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
US4782084A
(en)
|
1987-06-29 |
1988-11-01 |
Merck & Co., Inc. |
HMG-COA reductase inhibitors
|
US4820850A
(en)
|
1987-07-10 |
1989-04-11 |
Merck & Co., Inc. |
Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
|
US5030447A
(en)
|
1988-03-31 |
1991-07-09 |
E. R. Squibb & Sons, Inc. |
Pharmaceutical compositions having good stability
|
US5180589A
(en)
|
1988-03-31 |
1993-01-19 |
E. R. Squibb & Sons, Inc. |
Pravastatin pharmaceuatical compositions having good stability
|
US4916239A
(en)
|
1988-07-19 |
1990-04-10 |
Merck & Co., Inc. |
Process for the lactonization of mevinic acids and analogs thereof
|
EP0360390A1
(en)
|
1988-07-25 |
1990-03-28 |
Glaxo Group Limited |
Spirolactam derivatives
|
US5118853A
(en)
|
1988-10-13 |
1992-06-02 |
Sandoz Ltd. |
Processes for the synthesis of 3-disubstituted aminoacroleins
|
US5290946A
(en)
|
1988-10-13 |
1994-03-01 |
Sandoz Ltd. |
Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
|
WO1990005525A1
(en)
|
1988-11-23 |
1990-05-31 |
Pfizer Inc. |
Quinuclidine derivatives as substance p antagonists
|
US4929437A
(en)
|
1989-02-02 |
1990-05-29 |
Merck & Co., Inc. |
Coenzyme Q10 with HMG-CoA reductase inhibitors
|
US5164372A
(en)
|
1989-04-28 |
1992-11-17 |
Fujisawa Pharmaceutical Company, Ltd. |
Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
|
US5189164A
(en)
|
1989-05-22 |
1993-02-23 |
Sandoz Ltd. |
Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
PH27357A
(en)
|
1989-09-22 |
1993-06-21 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives and pharmaceutical compositions comprising the same
|
US5286634A
(en)
|
1989-09-28 |
1994-02-15 |
Stadler Joan K |
Synergistic method for host cell transformation
|
FI97540C
(fi)
|
1989-11-06 |
1997-01-10 |
Sanofi Sa |
Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
|
FR2654725B1
(fr)
|
1989-11-23 |
1992-02-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2654726B1
(fr)
|
1989-11-23 |
1992-02-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'isoindolone et leur preparation.
|
GB8929070D0
(en)
|
1989-12-22 |
1990-02-28 |
Fujisawa Pharmaceutical Co |
Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
|
WO1991009844A1
(en)
|
1990-01-04 |
1991-07-11 |
Pfizer Inc. |
Substance p antagonists
|
US5232929A
(en)
|
1990-11-28 |
1993-08-03 |
Pfizer Inc. |
3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
EP0515681A4
(en)
|
1990-02-15 |
1993-12-29 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compound
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
US5420245A
(en)
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
AU648317B2
(en)
|
1990-06-01 |
1994-04-21 |
Pfizer Inc. |
3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them
|
DK0540526T3
(da)
|
1990-07-23 |
1995-04-18 |
Pfizer |
Quinuclidinderivater
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
ATE121389T1
(de)
|
1990-09-28 |
1995-05-15 |
Pfizer |
Ringverknüpfte analoge von stickstoffenthaltenden nichtaromatischen heterocyclen.
|
GB9023116D0
(en)
|
1990-10-24 |
1990-12-05 |
Fujisawa Pharmaceutical Co |
Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
|
ATE129409T1
(de)
|
1990-12-21 |
1995-11-15 |
Fujisawa Pharmaceutical Co |
Neue verwendung von peptidderivat.
|
EP0566589A1
(en)
|
1991-01-10 |
1993-10-27 |
Pfizer Inc. |
N-alkyl quinuclidinium salts as substance p antagonists
|
ATE154354T1
(de)
|
1991-02-11 |
1997-06-15 |
Merck Sharp & Dohme |
Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung
|
ES2065175T3
(es)
|
1991-03-01 |
1995-02-01 |
Pfizer |
Derivados de 1-azabiciclo(3.2.2)nonan-3-amina.
|
US5747469A
(en)
|
1991-03-06 |
1998-05-05 |
Board Of Regents, The University Of Texas System |
Methods and compositions comprising DNA damaging agents and p53
|
CA2106200C
(en)
|
1991-03-26 |
1996-11-19 |
Terry J. Rosen |
Stereoselective preparation of substituted piperidines
|
FR2677361A1
(fr)
|
1991-06-04 |
1992-12-11 |
Adir |
Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676053B1
(fr)
|
1991-05-03 |
1993-08-27 |
Sanofi Elf |
Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
FR2676055B1
(fr)
|
1991-05-03 |
1993-09-03 |
Sanofi Elf |
Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
|
FR2676443B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole et leur preparation.
|
FR2676442B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676446B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
FR2676447B1
(fr)
|
1991-05-17 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux derives du thiopyranopyrrole et leur preparation.
|
US5292726A
(en)
|
1991-05-22 |
1994-03-08 |
Merck & Co., Inc. |
N,N-diacylpiperazines
|
PL170513B1
(en)
|
1991-05-22 |
1996-12-31 |
Pfizer |
Method of obtaining novel derivatives of 3-amino quinuclidine
|
PL171379B1
(en)
|
1991-05-31 |
1997-04-30 |
Pfizer |
Method of obtaining novel derivatives of quinuclidine
|
GB9113219D0
(en)
|
1991-06-19 |
1991-08-07 |
Fujisawa Pharmaceutical Co |
Peptide compound,processes for preparation thereof and pharmaceutical composition comprising the same
|
ATE142199T1
(de)
|
1991-06-20 |
1996-09-15 |
Pfizer |
Fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen
|
TW202432B
(lt)
|
1991-06-21 |
1993-03-21 |
Pfizer |
|
US5288730A
(en)
|
1991-06-24 |
1994-02-22 |
Merck Sharp & Dohme Limited |
Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
|
EP0536817A1
(en)
|
1991-07-05 |
1993-04-14 |
MERCK SHARP & DOHME LTD. |
Azabicyclic compounds as tachykinin antagonists
|
ATE133657T1
(de)
|
1991-07-05 |
1996-02-15 |
Merck Sharp & Dohme |
Aromatische verbindungen, diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische anwendung
|
WO1993001169A2
(en)
|
1991-07-05 |
1993-01-21 |
Merck Sharp & Dohme Limited |
Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
|
US5495047A
(en)
|
1991-07-10 |
1996-02-27 |
Merck, Sharp & Dohme (Ltd.) |
Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy
|
DE69208089T2
(de)
|
1991-07-10 |
1996-08-22 |
Merck Sharp & Dohme |
Aromatische verbindungen diese enthaltende pharmazeutische zusammensetzungen und ihre therapeutische verwendung
|
MY110227A
(en)
|
1991-08-12 |
1998-03-31 |
Ciba Geigy Ag |
1-acylpiperindine compounds.
|
US5459270A
(en)
|
1991-08-20 |
1995-10-17 |
Merck Sharp & Dohme Limited |
Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
|
EP0916346A3
(en)
|
1991-09-20 |
2000-12-06 |
Glaxo Group Limited |
NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis
|
HU9400728D0
(en)
|
1991-09-26 |
1994-06-28 |
Pfizer |
Fused tricyclic nitrogen containing heterocycles as substance p receptor antagonists
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
WO1993009116A1
(en)
|
1991-11-07 |
1993-05-13 |
Yoshitomi Pharmaceutical Industries, Ltd. |
Quinuclidine compound and medicinal use thereof
|
EP0613458B1
(en)
|
1991-11-12 |
1998-01-07 |
Pfizer Inc. |
Acyclic ethylenediamine derivatives as substance p receptor antagonists
|
CA2083891A1
(en)
|
1991-12-03 |
1993-06-04 |
Angus Murray Macleod |
Heterocyclic compounds, compositions containing them and their use in therapy
|
HU9203780D0
(en)
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
GB9200535D0
(en)
|
1992-01-10 |
1992-02-26 |
Fujisawa Pharmaceutical Co |
New compound
|
GB9201179D0
(en)
|
1992-01-21 |
1992-03-11 |
Glaxo Group Ltd |
Chemical compounds
|
US5328927A
(en)
|
1992-03-03 |
1994-07-12 |
Merck Sharpe & Dohme, Ltd. |
Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them
|
JP2656702B2
(ja)
|
1992-03-23 |
1997-09-24 |
ファイザー製薬株式会社 |
ペプチド性キヌクリジン
|
FR2689888B1
(fr)
|
1992-04-10 |
1994-06-10 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
|
EP0636130A1
(en)
|
1992-04-15 |
1995-02-01 |
Merck Sharp & Dohme Ltd. |
Azacyclic compounds
|
GB2266529A
(en)
|
1992-05-01 |
1993-11-03 |
Merck Sharp & Dohme |
Tetrahydroisoquinoline derivatives
|
CA2135646A1
(en)
|
1992-05-11 |
1993-11-25 |
Kenneth G. Draper |
Method and reagent for inhibiting viral replication
|
US20030206887A1
(en)
*
|
1992-05-14 |
2003-11-06 |
David Morrissey |
RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
|
US5977343A
(en)
|
1992-05-14 |
1999-11-02 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
EP0641328B1
(en)
|
1992-05-18 |
2001-11-21 |
Pfizer Inc. |
Bridged aza-bicyclic derivatives as substance p antagonists
|
GB9211193D0
(en)
|
1992-05-27 |
1992-07-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5719147A
(en)
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
IL106142A
(en)
|
1992-06-29 |
1997-03-18 |
Merck & Co Inc |
Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
|
US5637699A
(en)
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
US5612336A
(en)
|
1992-07-13 |
1997-03-18 |
Merck, Sharp & Dohme Ltd. |
Heterocyclic amide derivatives as tachykinin antagonists
|
WO1994002595A1
(en)
|
1992-07-17 |
1994-02-03 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of animal diseases
|
GB2268931A
(en)
|
1992-07-22 |
1994-01-26 |
Merck Sharp & Dohme |
Azabicyclic tachykinin-receptor antagonists
|
AU675447B2
(en)
|
1992-07-28 |
1997-02-06 |
Merck Sharp & Dohme Limited |
Carboxamidomethyl piperidine and analogues
|
GB2269170A
(en)
|
1992-07-29 |
1994-02-02 |
Merck Sharp & Dohme |
Azatricyclic tachykinin antagonists
|
WO1994003429A1
(en)
|
1992-07-31 |
1994-02-17 |
Merck Sharp & Dohme Limited |
Substituted amines as tachykinin receptor antagonists
|
EP0654029A1
(en)
|
1992-08-04 |
1995-05-24 |
Pfizer Inc. |
3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
|
GB9216911D0
(en)
|
1992-08-10 |
1992-09-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
JP3507494B2
(ja)
|
1992-08-13 |
2004-03-15 |
ワーナー−ランバート・コンパニー |
タキキニン拮抗薬
|
ES2164072T3
(es)
|
1992-08-19 |
2002-02-16 |
Pfizer |
Heterociclos no aromaticos que contienen nitrogeno sustituidos con bencilamino.
|
US5387595A
(en)
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
NO179904C
(no)
|
1992-09-04 |
1997-01-08 |
Takeda Chemical Industries Ltd |
Kondenserte heterocykliske forbindelser og deres anvendelse
|
US5563161A
(en)
|
1992-09-10 |
1996-10-08 |
Merck Sharp & Dohme Ltd. |
Alcohols and ethers with aromatic substituents as tachykinin-antagonists
|
US6235886B1
(en)
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
GB9220286D0
(en)
|
1992-09-25 |
1992-11-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
JP2656699B2
(ja)
|
1992-10-21 |
1997-09-24 |
ファイザー製薬株式会社 |
置換ベンジルアミノキヌクリジン
|
GB9222262D0
(en)
|
1992-10-23 |
1992-12-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9222486D0
(en)
|
1992-10-26 |
1992-12-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
JPH08502510A
(ja)
|
1992-10-28 |
1996-03-19 |
メルク シヤープ エンド ドーム リミテツド |
タキキニン拮抗剤としてのアリールメチルオキシメチルピペリジン
|
JP2656700B2
(ja)
|
1992-10-28 |
1997-09-24 |
ファイザー製薬株式会社 |
置換キヌクリジン誘導体
|
US5554627A
(en)
|
1992-10-30 |
1996-09-10 |
Merck, Sharp & Dohme Ltd. |
Tachykinin antagonists
|
NZ254604A
(en)
|
1992-11-12 |
1997-06-24 |
Pfizer |
Quinuclidine derivative and pharmaceutical compositions thereof
|
US5261188A
(en)
|
1992-11-23 |
1993-11-16 |
The Standard Products Company |
Belt weatherstrip with bulb
|
PT675886E
(pt)
|
1992-12-10 |
2000-12-29 |
Pfizer |
Heterociclos nao aromaticos com substituintes aminometileno e sua utilizacao como antagonistas da substancia p
|
US5604260A
(en)
|
1992-12-11 |
1997-02-18 |
Merck Frosst Canada Inc. |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
|
US5661162A
(en)
|
1992-12-14 |
1997-08-26 |
Merck Sharp & Dohme Limited |
4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperdines as tachykinin receptor antagonists
|
GB9226581D0
(en)
|
1992-12-21 |
1993-02-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2111902A1
(en)
|
1992-12-21 |
1994-06-22 |
Jack Beuford Campbell |
Antitumor compositions and methods of treatment
|
GB9300051D0
(en)
|
1993-01-04 |
1993-03-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU6027694A
(en)
|
1993-01-15 |
1994-08-15 |
G.D. Searle & Co. |
Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
|
US5466689A
(en)
|
1993-02-08 |
1995-11-14 |
Takeda Chemical Industries, Ltd. |
Morpholine derivatives and their use
|
ES2116583T3
(es)
|
1993-02-18 |
1998-07-16 |
Merck Sharp & Dohme |
Compuestos azaciclicos, composiciones que los contienen y su uso como antagonistas de taquicininas.
|
US5674889A
(en)
|
1993-02-22 |
1997-10-07 |
Merck, Sharp & Dohme, Ltd. |
Aromatic compounds, compositions containing them and their use in therapy
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
US5298627A
(en)
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
CA2157117C
(en)
|
1993-03-04 |
1999-01-05 |
Manoj C. Desai |
Spirocyclic piperidine derivatives
|
US5409944A
(en)
|
1993-03-12 |
1995-04-25 |
Merck Frosst Canada, Inc. |
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
|
ES2122261T3
(es)
|
1993-03-17 |
1998-12-16 |
Minnesota Mining & Mfg |
Formulacion de aerosol que contiene un adyuvante de dispersion derivado de un ester, una amida o un mercaptoester.
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
US5496833A
(en)
|
1993-04-13 |
1996-03-05 |
Merck Sharp & Dohme Limited |
Piperidine tachykinin receptor antagonists
|
EP0696280B1
(en)
|
1993-05-06 |
1997-09-24 |
Merrell Pharmaceuticals Inc. |
Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
|
WO1994026723A2
(en)
|
1993-05-14 |
1994-11-24 |
Genentech, Inc. |
ras FARNESYL TRANSFERASE INHIBITORS
|
US5602098A
(en)
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
IL109646A0
(en)
|
1993-05-19 |
1994-08-26 |
Pfizer |
Heteroatom substituted alkyl benzylamino-quinuclidines
|
US5380738A
(en)
|
1993-05-21 |
1995-01-10 |
Monsanto Company |
2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
|
AU680020B2
(en)
|
1993-06-07 |
1997-07-17 |
Merck & Co., Inc. |
Spiro-substituted azacycles as neurokinin antagonists
|
GB9602877D0
(en)
|
1996-02-13 |
1996-04-10 |
Merck Frosst Canada Inc |
3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
|
US5436265A
(en)
|
1993-11-12 |
1995-07-25 |
Merck Frosst Canada, Inc. |
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
|
US5474995A
(en)
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
EP0634402A1
(en)
|
1993-07-14 |
1995-01-18 |
Takeda Chemical Industries, Ltd. |
Isochinolinone derivatives, their production and use
|
US5869499A
(en)
|
1993-07-15 |
1999-02-09 |
Pfizer Inc |
Benzyloxyquinuclidines as substance P antagonists
|
GB9315808D0
(en)
|
1993-07-30 |
1993-09-15 |
Merck Sharp & Dohme |
Therapeutic agents
|
TW365603B
(en)
|
1993-07-30 |
1999-08-01 |
Rhone Poulenc Rorer Sa |
Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
|
GB9317987D0
(en)
|
1993-08-26 |
1993-10-13 |
Glaxo Group Ltd |
Chemical compounds
|
AU679566B2
(en)
|
1993-09-03 |
1997-07-03 |
Isis Pharmaceuticals, Inc. |
Amine-derivatized nucleosides and oligonucleosides
|
EP1209157A1
(en)
|
1993-09-17 |
2002-05-29 |
Pfizer Inc. |
Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds
|
DE69433744T2
(de)
|
1993-09-17 |
2004-10-14 |
Pfizer Inc. |
3-amino-5-carboxy-substituierte piperidine und 3-amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten
|
WO1995008542A1
(fr)
|
1993-09-22 |
1995-03-30 |
Kyowa Hakko Kogyo Co., Ltd. |
Inhibiteur de la farnesyl-transferase
|
IL111002A
(en)
|
1993-09-22 |
1998-09-24 |
Glaxo Group Ltd |
History of piperidine, their preparation and the pharmaceutical preparations containing them
|
US5624803A
(en)
|
1993-10-14 |
1997-04-29 |
The Regents Of The University Of California |
In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
|
US5661152A
(en)
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
WO1995010514A1
(en)
|
1993-10-15 |
1995-04-20 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
DE69429438T2
(de)
|
1993-10-15 |
2002-08-08 |
Schering Corp., Kenilworth |
Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
|
ES2157994T3
(es)
|
1993-10-25 |
2001-09-01 |
Parke Davis & Co |
Inhibidores tetra y pentapeptidos sustituidos de la proteina farnesiltransferasa.
|
WO1995011880A1
(en)
|
1993-10-27 |
1995-05-04 |
Merck Sharp & Dohme Limited |
Substituted amides as tachykinin antagonists
|
US5344991A
(en)
|
1993-10-29 |
1994-09-06 |
G.D. Searle & Co. |
1,2 diarylcyclopentenyl compounds for the treatment of inflammation
|
DK0677039T3
(da)
|
1993-11-04 |
1999-09-27 |
Abbott Lab |
Cyclobutanderivater som squalen-syntetase- og protein-farnesyltransferaseinhibitorer
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
NZ275691A
(en)
|
1993-11-05 |
1998-03-25 |
Warner Lambert Co |
Di and tripeptides and compositions thereof which inhibit farnesyl transferase
|
US6403577B1
(en)
|
1993-11-17 |
2002-06-11 |
Eli Lilly And Company |
Hexamethyleneiminyl tachykinin receptor antagonists
|
US5466823A
(en)
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
IT1271462B
(it)
|
1993-12-03 |
1997-05-28 |
Menarini Farma Ind |
Antagonisti delle tachichinine,procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche.
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
IL111960A
(en)
|
1993-12-17 |
1999-12-22 |
Merck & Co Inc |
Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
|
JPH09506898A
(ja)
|
1993-12-21 |
1997-07-08 |
イーライ・リリー・アンド・カンパニー |
非ペプチドタキキニン受容体アンタゴニスト
|
ES2164758T3
(es)
|
1993-12-29 |
2002-03-01 |
Merck Sharp & Dohme |
Derivados de morfolina sustituidos y su uso como agentes terapeuticos.
|
JP2895630B2
(ja)
|
1993-12-29 |
1999-05-24 |
フアイザー・インコーポレイテツド |
ジアザビシクロニューロキニンアンタゴニスト
|
AU685212B2
(en)
|
1994-01-13 |
1998-01-15 |
Merck Sharp & Dohme Limited |
Gem-disubstituted azacyclic tachykinin antagonists
|
AU1462795A
(en)
|
1994-01-28 |
1995-08-15 |
Merck Sharp & Dohme Limited |
Aralkylamino substituted azacyclic therapeutic agents
|
US5393790A
(en)
|
1994-02-10 |
1995-02-28 |
G.D. Searle & Co. |
Substituted spiro compounds for the treatment of inflammation
|
GB9402688D0
(en)
|
1994-02-11 |
1994-04-06 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5610165A
(en)
|
1994-02-17 |
1997-03-11 |
Merck & Co., Inc. |
N-acylpiperidine tachykinin antagonists
|
US5902880A
(en)
|
1994-08-19 |
1999-05-11 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
TW385308B
(en)
|
1994-03-04 |
2000-03-21 |
Merck & Co Inc |
Prodrugs of morpholine tachykinin receptor antagonists
|
WO1995024612A1
(de)
|
1994-03-07 |
1995-09-14 |
International Business Machines Corporation |
Verfahren und vorrichtung zur schnellen interpolation von zwischenwerten aus periodischen phasenverschobenen signalen und zur erkennung von defekten in einem drehkörper
|
AU2122795A
(en)
|
1994-03-15 |
1995-10-03 |
Eisai Co. Ltd. |
Isoprenyl transferase inhibitors
|
FR2718136B1
(fr)
|
1994-03-29 |
1996-06-21 |
Sanofi Sa |
Composés aromatiques aminés, procédé pour leur obtention et compositions pharmaceutiques les contenant.
|
AU1615895A
(en)
|
1994-03-31 |
1995-10-12 |
Bristol-Myers Squibb Company |
Imidazole-containing inhibitors of farnesyl protein transferase
|
US5523430A
(en)
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
US5610145A
(en)
|
1994-04-15 |
1997-03-11 |
Warner-Lambert Company |
Tachykinin antagonists
|
IL113472A0
(en)
|
1994-04-29 |
1995-07-31 |
Lilly Co Eli |
Non-peptidyl tachykinin receptor antogonists
|
JPH10500944A
(ja)
|
1994-05-05 |
1998-01-27 |
メルク シヤープ エンド ドーム リミテツド |
モルホリン誘導体及びタキキニンのアンタゴニストとしてのそれらの使用
|
JPH09512806A
(ja)
|
1994-05-07 |
1997-12-22 |
ベーリンガー インゲルハイム コマンディトゲゼルシャフト |
新規なアミノ酸誘導体、その製造方法及びこれらの化合物を含む医薬組成物(ii)
|
US5510510A
(en)
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
US6447796B1
(en)
|
1994-05-16 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Sustained release hydrophobic bioactive PLGA microspheres
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
NZ287284A
(en)
|
1994-06-06 |
1998-10-28 |
Warner Lambert Co |
N-[2-(phenyl(substituted)ethylamino)-1-(indolylmethyl)-1-methyl -2-oxoethyl] carbamic acid ester derivatives, medicaments and intermediates
|
EP0686629A3
(en)
|
1994-06-10 |
1999-02-10 |
Eli Lilly And Company |
Cyclohexyl tachykinine receptor antagonists
|
WO1995034535A1
(fr)
|
1994-06-10 |
1995-12-21 |
Rhone-Poulenc Rorer S.A. |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
US5571792A
(en)
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
RU2151769C1
(ru)
|
1994-07-12 |
2000-06-27 |
Эли Лилли Энд Компани |
Тригидрат дигидрохлорида (r)-3-(1н-индол-3-ил)-1-[n-(2-метоксибензил)ацетиламино]-2-[n-(2-(4-(пиперидин-1-ил)пиперидин-1-ил)ацетил)амино]пропана и фармацевтический состав
|
CA2154116A1
(en)
|
1994-07-22 |
1996-01-23 |
Philip Arthur Hipskind |
1-aryl-2-acetamidopentanone derivatives for use as tachykinin receptor antagonists
|
GB9415997D0
(en)
|
1994-08-08 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9415996D0
(en)
|
1994-08-08 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
TW432061B
(en)
|
1994-08-09 |
2001-05-01 |
Pfizer Res & Dev |
Lactams
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
WO1996005168A1
(fr)
|
1994-08-11 |
1996-02-22 |
Banyu Pharmaceutical Co., Ltd. |
Derive d'amide substitue
|
EP0805154A1
(en)
|
1994-08-12 |
1997-11-05 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
PT777659E
(pt)
|
1994-08-15 |
2001-09-28 |
Merck Sharp & Dohme |
Derivados de morfolina e sua utilizacao como agentes terapeuticos
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
US6146886A
(en)
|
1994-08-19 |
2000-11-14 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
HU221434B
(en)
|
1994-08-25 |
2002-10-28 |
Merrell Pharma Inc |
Substituted piperidines, pharmaceutical compositions containing them and their use
|
EP0699655B1
(en)
|
1994-08-29 |
1997-09-24 |
Akzo Nobel N.V. |
Process for the preparation of quaternary diesters
|
GB9417956D0
(en)
|
1994-09-02 |
1994-10-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9418545D0
(en)
|
1994-09-15 |
1994-11-02 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5457107A
(en)
|
1994-09-16 |
1995-10-10 |
Merck & Co., Inc. |
Polymorphic form of a tachykinin receptor antagonist
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
DE69525355T2
(de)
|
1994-09-30 |
2002-09-19 |
Novartis Ag, Basel |
1-acyl-4-aliphatische aminopiperidin verbindungen
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
TW397825B
(en)
|
1994-10-14 |
2000-07-11 |
Novartis Ag |
Aroyl-piperidine derivatives
|
FR2725986B1
(fr)
|
1994-10-21 |
1996-11-29 |
Adir |
Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
EP0709375B1
(en)
|
1994-10-25 |
2005-05-18 |
AstraZeneca AB |
Therapeutic heterocycles
|
GB9421709D0
(en)
|
1994-10-27 |
1994-12-14 |
Zeneca Ltd |
Therapeutic compounds
|
DE69507284T2
(de)
|
1994-11-22 |
1999-07-01 |
Philips Electronics N.V., Eindhoven |
Halbleiter mit einem träger auf dem ein substrat mit einem halbleiter-element mittels einer klebeschicht und ein leiterbahn-muster befestigt sind
|
CA2162786A1
(en)
|
1994-11-22 |
1996-05-23 |
Philip Arthur Hipskind |
Heterocyclic tachykinin receptor antagonists
|
FR2727411B1
(fr)
|
1994-11-30 |
1997-01-03 |
Rhone Poulenc Rorer Sa |
Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
|
AU3971295A
(en)
|
1994-12-09 |
1996-06-26 |
Warner-Lambert Company |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
AU4412096A
(en)
|
1994-12-13 |
1996-07-03 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
|
PE38997A1
(es)
|
1994-12-13 |
1997-10-02 |
Novartis Ag |
Antagonista de taquicinina
|
GB9426103D0
(en)
|
1994-12-23 |
1995-02-22 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2211017A1
(en)
|
1995-01-09 |
1996-07-18 |
Magla International Ltd. |
Wear resistant image printing on latex surfaces
|
ES2229259T3
(es)
|
1995-01-12 |
2005-04-16 |
Glaxo Group Limited |
Derivados de piperidina con actividad antagonista de taquiquinina.
|
EP0794789A4
(en)
|
1995-01-12 |
1999-05-26 |
Univ Pittsburgh |
PRENYL TRANSFERASE INHIBITORS
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
FR2729951B1
(fr)
|
1995-01-30 |
1997-04-18 |
Sanofi Sa |
Nouveaux composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques en contenant
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
US5633272A
(en)
|
1995-02-13 |
1997-05-27 |
Talley; John J. |
Substituted isoxazoles for the treatment of inflammation
|
GB9505492D0
(en)
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9505491D0
(en)
|
1995-03-18 |
1995-05-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5554641A
(en)
|
1995-03-20 |
1996-09-10 |
Horwell; David C. |
Nonpeptides as tachykinin antagonists
|
GB9505692D0
(en)
|
1995-03-21 |
1995-05-10 |
Glaxo Group Ltd |
Chemical compounds
|
TW394773B
(en)
|
1995-03-24 |
2000-06-21 |
Takeda Chemical Industries Ltd |
Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
US5565568A
(en)
|
1995-04-06 |
1996-10-15 |
Eli Lilly And Company |
2-acylaminopropanamides as tachykinin receptor antagonists
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
JP3038016B2
(ja)
|
1995-04-07 |
2000-05-08 |
シェーリング コーポレイション |
ファルネシルタンパク質トランスフェラーゼを阻害する、カルボニルピペラジニルおよびカルボニルピペリジニル化合物
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
ATE277021T1
(de)
|
1995-04-13 |
2004-10-15 |
Aventis Pharma Inc |
Neue substituierte piperazinderivate mit tachykininrezeptor-antagonistischer wirkung
|
EE03997B1
(et)
|
1995-04-14 |
2003-04-15 |
Glaxo Wellcome Inc. |
Albuterooli doseeriv inhalaator
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
EP0846116A1
(en)
|
1995-05-25 |
1998-06-10 |
Fujisawa Pharmaceutical Co., Ltd. |
1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
CA2222328C
(en)
|
1995-06-07 |
2012-01-10 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
WO1997000252A1
(en)
|
1995-06-16 |
1997-01-03 |
Warner-Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
GB9513118D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9513121D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9513117D0
(en)
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
DE69612003T2
(de)
|
1995-07-07 |
2001-06-21 |
Pfizer Inc., New York |
Substituierte benzolaktamverbindungen als substanz-p-antagonisten
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
TW340842B
(en)
|
1995-08-24 |
1998-09-21 |
Pfizer |
Substituted benzylaminopiperidine compounds
|
US6020343A
(en)
|
1995-10-13 |
2000-02-01 |
Merck Frosst Canada, Inc. |
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
|
WO1997014671A1
(en)
|
1995-10-18 |
1997-04-24 |
Merck & Co., Inc. |
Cyclopentyl tachykinin receptor antagonists
|
DE69627377T2
(de)
|
1995-11-06 |
2004-02-05 |
University Of Pittsburgh |
Inhibitoren der protein-isoprenyl-transferase
|
DE19541283A1
(de)
|
1995-11-06 |
1997-05-07 |
Boehringer Ingelheim Kg |
Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
|
GB9523244D0
(en)
|
1995-11-14 |
1996-01-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
ATE218556T1
(de)
|
1995-11-17 |
2002-06-15 |
Biotechnolog Forschung Gmbh |
Epothilon-derivate und deren herstellung
|
EP0862435A4
(en)
|
1995-11-22 |
1999-02-03 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
JP2000500760A
(ja)
|
1995-11-23 |
2000-01-25 |
メルク シヤープ エンド ドーム リミテツド |
スピロピペリジン誘導体およびタキキニン拮抗薬としてのその使用
|
GB9524157D0
(en)
|
1995-11-25 |
1996-01-24 |
Pfizer Ltd |
Therapeutic agents
|
RU2135494C1
(ru)
|
1995-12-01 |
1999-08-27 |
Санкио Компани Лимитед |
Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
|
TR199800825T2
(xx)
|
1995-12-08 |
1998-08-21 |
Janssen Pharmaceutica N.V. |
Farnesil protein transferini inhibe eden (imidazol-5-il) metil-2-kinolinon t�revleri.
|
GB9525296D0
(en)
|
1995-12-11 |
1996-02-07 |
Merck Sharp & Dohme |
Therapeutic agents
|
PL185597B1
(pl)
|
1995-12-22 |
2003-06-30 |
Schering Corp |
Tricykliczne amidy, środek farmaceutyczny i ich zastosowania
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
WO1997026246A1
(en)
|
1996-01-16 |
1997-07-24 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
AU715202B2
(en)
|
1996-04-03 |
2000-01-20 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
WO1997038986A1
(en)
|
1996-04-12 |
1997-10-23 |
G.D. Searle & Co. |
Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors
|
GEP20012500B
(en)
|
1996-05-22 |
2001-07-25 |
Warner Lambert Co |
Inhibitors of Protein Farnesyl Transferase
|
CA2260216A1
(en)
|
1996-07-15 |
1998-01-22 |
Bristol-Myers Squibb Company |
Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
|
US5861419A
(en)
|
1996-07-18 |
1999-01-19 |
Merck Frosst Canad, Inc. |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
|
DE69734362T2
(de)
|
1996-12-03 |
2006-07-20 |
Sloan-Kettering Institute For Cancer Research |
Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
|
AUPO434196A0
(en)
|
1996-12-24 |
1997-01-23 |
Crown In The Right Of The Queensland Department Of Health, The |
An improved therapeutic
|
JP2001507699A
(ja)
|
1996-12-30 |
2001-06-12 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシル蛋白トランスフェラーゼ阻害薬
|
EP1003374A4
(en)
|
1996-12-30 |
2000-05-31 |
Merck & Co Inc |
INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
|
US6001311A
(en)
|
1997-02-05 |
1999-12-14 |
Protogene Laboratories, Inc. |
Apparatus for diverse chemical synthesis using two-dimensional array
|
US6126919A
(en)
|
1997-02-07 |
2000-10-03 |
3M Innovative Properties Company |
Biocompatible compounds for pharmaceutical drug delivery systems
|
US6235310B1
(en)
|
1997-04-04 |
2001-05-22 |
Valentis, Inc. |
Methods of delivery using cationic lipids and helper lipids
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
EP1027033B1
(en)
|
1997-05-14 |
2009-07-22 |
The University Of British Columbia |
High efficiency encapsulation of nucleic acids in lipid vesicles
|
AU7983798A
(en)
|
1997-06-23 |
1999-01-04 |
Sequus Pharmaceuticals, Inc. |
Liposome-entrapped polynucleotide composition and method
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
TW589189B
(en)
|
1997-08-04 |
2004-06-01 |
Scras |
Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
|
US6054576A
(en)
|
1997-10-02 |
2000-04-25 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
JP2002500201A
(ja)
|
1998-01-05 |
2002-01-08 |
ユニバーシティ オブ ワシントン |
膜破壊剤を使用する増強された輸送
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
CA2326823A1
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
GB9827152D0
(en)
|
1998-07-03 |
1999-02-03 |
Devgen Nv |
Characterisation of gene function using double stranded rna inhibition
|
CA2335393C
(en)
|
1998-07-20 |
2008-09-23 |
Inex Pharmaceuticals Corporation |
Liposomal encapsulated nucleic acid-complexes
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
CA2361201A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Kdrに特異的な抗体およびその使用
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
ATE408699T1
(de)
|
1999-03-10 |
2008-10-15 |
Phogen Ltd |
Verabreichung von nukleinsäuren und proteinen an zellen
|
AU4972900A
(en)
|
1999-04-08 |
2000-11-14 |
Arch Development Corporation |
Use of anti-vegf antibody to enhance radiation in cancer therapy
|
DE60026030T2
(de)
|
1999-07-14 |
2006-08-10 |
Alza Corp., Mountain View |
Neutrales lipopolymer und liposomale zusammensetzungen daraus
|
AU1086501A
(en)
|
1999-10-15 |
2001-04-30 |
Carnegie Institution Of Washington |
Rna interference pathway genes as tools for targeted genetic interference
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
CA2388646C
(en)
|
1999-10-27 |
2009-01-27 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US6401406B1
(en)
|
2000-02-11 |
2002-06-11 |
Domald K. Komara |
Retainment device for concrete block inspection plates
|
US7365196B2
(en)
|
2000-03-20 |
2008-04-29 |
Merck Sharp & Dohme Ltd. |
Sulphonamido-substituted bridged bicycloalkyl derivatives
|
GB0012671D0
(en)
|
2000-05-24 |
2000-07-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
ATE506372T1
(de)
|
2000-09-01 |
2011-05-15 |
Ribozyme Pharm Inc |
Verfahren zur herstellung von nukleosidderivate
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
GB0025173D0
(en)
|
2000-10-13 |
2000-11-29 |
Merck Sharp & Dohme |
Therapeutic agents
|
US7138400B2
(en)
|
2000-11-02 |
2006-11-21 |
Merck Sharp & Dohme Limited |
Sulfamides as gamma-secretase inhibitors
|
UA74849C2
(en)
|
2000-11-17 |
2006-02-15 |
Lilly Co Eli |
Lactam
|
US20020130430A1
(en)
|
2000-12-29 |
2002-09-19 |
Castor Trevor Percival |
Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
|
US20050164220A1
(en)
|
2001-03-19 |
2005-07-28 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke: method of treatment
|
WO2004028341A2
(en)
|
2001-03-19 |
2004-04-08 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke; methods of treatment
|
GB0108592D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0108591D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
US6960584B2
(en)
|
2001-04-10 |
2005-11-01 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
WO2002083064A2
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
A method of treating cancer
|
ATE400274T1
(de)
|
2001-04-10 |
2008-07-15 |
Merck & Co Inc |
Hemmstoffe der akt aktivität
|
US6958334B2
(en)
|
2001-04-10 |
2005-10-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
WO2002087541A1
(en)
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20030158133A1
(en)
|
2001-08-01 |
2003-08-21 |
Movsesian Matthew A. |
Isoform-selective inhibitors and activators of PDE3 cyclic nucleotide phosphodiesterases
|
GB0119152D0
(en)
|
2001-08-06 |
2001-09-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2003013526A1
(en)
|
2001-08-08 |
2003-02-20 |
Merck & Co. Inc. |
Anticoagulant compounds
|
MXPA04001607A
(es)
|
2001-08-21 |
2004-07-08 |
Merck Sharp & Dohme |
Ciclohexilsulfonas novedosas.
|
WO2004012669A2
(en)
|
2002-08-01 |
2004-02-12 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides
|
US20050191627A1
(en)
|
2001-09-28 |
2005-09-01 |
Incyte Corporation |
Enzymes
|
FR2830766B1
(fr)
|
2001-10-12 |
2004-03-12 |
Optis France Sa |
Dispositif de delivrance de medicaments par iontophorese transpalpebrale
|
FR2830767B1
(fr)
|
2001-10-12 |
2004-03-12 |
Optis France Sa |
Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
US7141540B2
(en)
|
2001-11-30 |
2006-11-28 |
Genta Salus Llc |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
|
JP4464136B2
(ja)
|
2001-12-06 |
2010-05-19 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有糸分裂キネシン阻害薬
|
US7244723B2
(en)
|
2001-12-06 |
2007-07-17 |
Merck & Co., Inc. |
Substituted furopyrimidinones as a mitotic kinesin inhibitors
|
ATE447577T1
(de)
|
2001-12-06 |
2009-11-15 |
Merck & Co Inc |
Mitotische kinesin-hemmer
|
ES2291543T3
(es)
|
2001-12-06 |
2008-03-01 |
MERCK & CO., INC. |
Inhibicion de kinesina mitotica.
|
DE60231439D1
(de)
|
2001-12-06 |
2009-04-16 |
Merck & Co Inc |
Mitotische kinesinhemmer
|
WO2003052075A2
(en)
|
2001-12-14 |
2003-06-26 |
Incyte Genomics, Inc. |
Enzymes
|
US7662952B2
(en)
*
|
2002-02-20 |
2010-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA)
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
EP1492487B1
(en)
|
2002-03-08 |
2009-11-11 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
AU2003226250B2
(en)
|
2002-04-08 |
2007-08-16 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
CA2480800C
(en)
|
2002-04-08 |
2008-09-23 |
Mark T. Bilodeau |
Inhibitors of akt activity
|
AU2003230802B2
(en)
|
2002-04-08 |
2007-08-09 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
AU2003226271B2
(en)
|
2002-04-08 |
2007-10-18 |
Merck Sharp & Dohme Corp. |
Fused quinoxaline derivatives as inhibitors of Akt activity
|
EP1496981A2
(en)
|
2002-04-08 |
2005-01-19 |
Merck & Co., Inc. |
Method of treating cancer
|
GB0209991D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU2003229932B2
(en)
|
2002-05-01 |
2008-12-11 |
Merck Sharp & Dohme Limited |
Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
|
GB0209997D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0209995D0
(en)
|
2002-05-01 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
US20050203110A1
(en)
|
2002-05-23 |
2005-09-15 |
Coleman Paul J. |
Mitotic kinesin inhibitors
|
WO2003099211A2
(en)
|
2002-05-23 |
2003-12-04 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
CA2486215A1
(en)
|
2002-06-14 |
2003-12-24 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
MXPA04012642A
(es)
|
2002-06-14 |
2005-03-23 |
Merck & Co Inc |
Inhibidores de la cinesina mitotica.
|
US20040077540A1
(en)
|
2002-06-28 |
2004-04-22 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
|
US6989442B2
(en)
|
2002-07-12 |
2006-01-24 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
WO2004011647A1
(en)
*
|
2002-07-26 |
2004-02-05 |
Chiron Corporation |
Modified small interfering rna molecules and methods of use
|
US8216609B2
(en)
|
2002-08-05 |
2012-07-10 |
Torrent Pharmaceuticals Limited |
Modified release composition of highly soluble drugs
|
GB0223038D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223040D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
WO2004037171A2
(en)
|
2002-10-18 |
2004-05-06 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
US8133903B2
(en)
|
2003-10-21 |
2012-03-13 |
Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center |
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
|
US20040102360A1
(en)
|
2002-10-30 |
2004-05-27 |
Barnett Stanley F. |
Combination therapy
|
JP2006507299A
(ja)
|
2002-10-30 |
2006-03-02 |
メルク エンド カムパニー インコーポレーテッド |
Akt活性の阻害薬
|
GB0225475D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0225474D0
(en)
|
2002-11-01 |
2002-12-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2004058700A2
(en)
|
2002-12-20 |
2004-07-15 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
EP1581497A4
(en)
|
2002-12-20 |
2009-03-18 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
US7816337B2
(en)
|
2003-02-18 |
2010-10-19 |
Roche Madison Inc. |
Reversible attachment of a membrane active polymer to a polynucleotide
|
WO2004080887A1
(en)
|
2003-03-07 |
2004-09-23 |
Massachusetts Institute Of Technology |
Three dimensional mecrofabrication
|
GB0308318D0
(en)
|
2003-04-10 |
2003-05-14 |
Merck Sharp & Dohme |
Therapeutic agents
|
US7304063B2
(en)
|
2003-04-24 |
2007-12-04 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
ATE446752T1
(de)
|
2003-04-24 |
2009-11-15 |
Merck & Co Inc |
Hemmer der akt aktivität
|
ATE512957T1
(de)
|
2003-04-24 |
2011-07-15 |
Merck Sharp & Dohme |
Hemmer der akt aktivität
|
CA2522430A1
(en)
|
2003-04-24 |
2004-11-11 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
AU2004238607B2
(en)
|
2003-05-16 |
2010-05-27 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones as gamma-secretase inhibitors
|
SI2270162T1
(sl)
|
2003-06-12 |
2019-03-29 |
Alnylam Pharmaceuticals Inc. |
Konzervirana HBV in HCV zaporedja uporabna za utišanje genov
|
GB0318447D0
(en)
|
2003-08-05 |
2003-09-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO2005018638A1
(en)
|
2003-08-13 |
2005-03-03 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
PE20050730A1
(es)
|
2003-08-15 |
2005-09-20 |
Merck & Co Inc |
Derivados de 2,5-dihidropirrol 2,2-disustituidos como inhibidores de quinesinas mitoticas
|
WO2005019206A1
(en)
|
2003-08-15 |
2005-03-03 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
AU2004264533B2
(en)
|
2003-08-15 |
2009-01-22 |
Merck Sharp & Dohme Corp. |
Mitotic kinesin inhibitors
|
EP1656146A4
(en)
|
2003-08-15 |
2009-04-15 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESIN
|
ATE509917T1
(de)
|
2003-09-24 |
2011-06-15 |
Merck Sharp & Dohme |
Gamma-secretase-inhibitoren
|
US7579455B2
(en)
|
2003-09-29 |
2009-08-25 |
Topigen Pharmaceutique Inc. |
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
|
JP4641526B2
(ja)
|
2003-11-03 |
2011-03-02 |
グラクソ グループ リミテッド |
流体分配デバイス
|
US20100145038A1
(en)
*
|
2003-11-24 |
2010-06-10 |
Merck & Co., Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US20060019912A1
(en)
|
2003-12-19 |
2006-01-26 |
Chiron Corporation |
Cell transfecting formulations of small interfering RNA related compositions and methods of making and use
|
US7294640B2
(en)
|
2004-02-06 |
2007-11-13 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
EP1737843B1
(en)
|
2004-04-09 |
2011-02-23 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
US7750151B2
(en)
|
2004-04-09 |
2010-07-06 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
US20060014289A1
(en)
|
2004-04-20 |
2006-01-19 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
WO2005120461A2
(en)
|
2004-05-17 |
2005-12-22 |
Inex Pharmaceuticals Corporation |
Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
|
US20060019258A1
(en)
|
2004-07-20 |
2006-01-26 |
Illumina, Inc. |
Methods and compositions for detection of small interfering RNA and micro-RNA
|
WO2006033756A2
(en)
*
|
2004-08-23 |
2006-03-30 |
Nucleonics, Inc. |
Multiple rna polymerase iii promoter expression constructs
|
US20060062758A1
(en)
|
2004-09-21 |
2006-03-23 |
Nastech Pharmaceutical Comapny Inc. |
Tight junction modulator peptide PN159 for enhanced mucosal delivery of therapeutic compounds
|
US8138161B2
(en)
*
|
2004-10-01 |
2012-03-20 |
Novartis Vaccines And Diagnostics, Inc. |
Modified small interfering RNA molecules and methods of use
|
EP1833967B1
(en)
|
2004-12-22 |
2011-04-27 |
Alnylam Pharmaceuticals, Inc. |
Conserved hbv and hcv sequences useful for gene silencing
|
US7404969B2
(en)
*
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
KR101012595B1
(ko)
*
|
2005-03-09 |
2011-02-07 |
재단법인 목암생명공학연구소 |
작은 간섭 rna 및 이를 포함하는 b형 간염 바이러스 치료용 약학 조성물
|
CA2622242A1
(en)
*
|
2005-09-12 |
2007-03-22 |
Somagenics Inc. |
Inhibition of viral gene expression using small interfering rna
|
EP2061443A4
(en)
|
2006-08-18 |
2013-07-24 |
Arrowhead Res Corp |
POLYCONJUGATE FOR IN VIVO ADMINISTRATION OF POLYNUCLEOTIDES
|
CA2689042A1
(en)
*
|
2007-02-16 |
2008-08-28 |
Merck & Co., Inc. |
Compositions and methods for potentiated activity of biologicaly active molecules
|
KR20100069679A
(ko)
*
|
2007-09-17 |
2010-06-24 |
재단법인 목암생명공학연구소 |
HBV 또는 HCV의 유전자 발현을 하향 조절하는 siRNA의 혈청 안정성 향상 및 면역 반응 저감 방법
|
US8058069B2
(en)
|
2008-04-15 |
2011-11-15 |
Protiva Biotherapeutics, Inc. |
Lipid formulations for nucleic acid delivery
|
CN101603042B
(zh)
*
|
2008-06-13 |
2013-05-01 |
厦门大学 |
可用于乙型肝炎病毒感染治疗的rna干扰靶点
|
CN101322847A
(zh)
*
|
2008-06-23 |
2008-12-17 |
淮安市第四人民医院 |
基于siRNA池干扰的复合载体介导的抗乙肝病毒基因药物
|
WO2010012244A1
(zh)
*
|
2008-08-01 |
2010-02-04 |
苏州瑞博生物技术有限公司 |
乙型肝炎病毒基因的小核酸干扰靶位点序列和小干扰核酸及组合物和应用
|
CN104119242B
(zh)
|
2008-10-09 |
2017-07-07 |
泰米拉制药公司 |
改善的氨基脂质和递送核酸的方法
|
WO2010048536A2
(en)
|
2008-10-23 |
2010-04-29 |
Alnylam Pharmaceuticals, Inc. |
Processes for preparing lipids
|
CA3039251C
(en)
|
2008-11-10 |
2024-01-09 |
Arbutus Biopharma Corporation |
Novel lipids and compositions for the delivery of therapeutics
|
WO2010080724A1
(en)
*
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
CA2751342C
(en)
|
2009-01-29 |
2019-05-07 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
|
LT2440183T
(lt)
|
2009-06-10 |
2018-08-10 |
Arbutus Biopharma Corporation |
Patobulinta lipido kompozicija
|
ES2651308T3
(es)
|
2009-10-16 |
2018-01-25 |
Glaxo Group Limited |
Inhibidores antisentido de HBV
|
CA2787411C
(en)
|
2010-01-20 |
2019-01-08 |
Magna International Inc. |
Bi-metallic component and method of making the same
|
CN108676800B
(zh)
|
2010-08-17 |
2022-11-11 |
瑟纳治疗公司 |
使用短干扰核酸(siNA)的乙型肝炎病毒(HBV)基因表达的RNA干扰介导的抑制
|
CN101948827A
(zh)
*
|
2010-08-19 |
2011-01-19 |
中国人民解放军第三〇二医院 |
一种低载量乙型肝炎病毒全基因组克隆的方法
|
LT3505528T
(lt)
*
|
2011-04-21 |
2021-04-26 |
Glaxo Group Limited |
Hepatito b viruso (hbv) raiškos moduliacija
|
ES2690538T3
(es)
|
2011-06-30 |
2018-11-21 |
Arrowhead Pharmaceuticals, Inc. |
Composiciones y métodos para inhibir la expresión génica del virus de la hepatitis B
|
CN102559657A
(zh)
*
|
2011-11-09 |
2012-07-11 |
中国人民解放军第三〇二医院 |
两片段连接法进行hbv全基因组克隆的方法
|