RU2017121299A - ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) - Google Patents
ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) Download PDFInfo
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A61K9/5107—Excipients; Inactive ingredients
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Claims (20)
1. Молекула двухцепочечной малой интерферирующей нуклеиновой кислоты (миНК), содержащая любой из R-008380648-000E, R-008380783-000R, R-008380665-000N, R-008380645-000D, R-008380408-000R, R-008380633-000U, R-008380767-000R, R-008380730-000C, R-008380777-000H, R-008380740-000V, R-008380558-000M, R-008380406-000Y, R-008380764-000P, R-008380772-000P, R-008380389-000D, R-008380362-000H, R-008380363-000S, R-008380340-000F, R-008380689-000H, R-008380756-000P, R-008380736-000E, R-008380757-000Y, R-008380753-000N, R-008380737-000N, R-008380734-000M или R-008380791-000R.
2. Композиция, содержащая двухцепочечную малую интерферирующую нуклеиновую кислоту (миНК) по п.1 и фармацевтически приемлемый носитель или разбавитель.
3. Композиция, содержащая:
(a) двухцепочечную малую интерферирующую нуклеиновую кислоту (миНК) по п.1;
(b) катионный липид;
(c) холестерин;
(d) DSPC и
(e) PEG-DMG.
4. Композиция, содержащая:
(a) двухцепочечную малую интерферирующую нуклеиновую кислоту (миНК) по п.1;
(b) (13Z,16Z)-N,N-диметил-3-нонилдокоза-13,16-диен-1-амин;
(c) холестерин;
(d) DSPC и
(e) PEG-DMG.
5. Композиция по п.4, где (13Z,16Z)-N,N-диметил-3-нонилдокоза-13,16-диен-1-амин, холестерин, DSPC и PEG-DMG находятся в молярном отношении 50:30:10:2, соответственно.
6. Композиция, содержащая композицию по п.5 и фармацевтически приемлемый носитель или разбавитель.
7. Способ лечения индивидуума, являющегося человеком, страдающего состоянием, опосредованного действием или потерей действия вируса гепатита B (HBV), включающий введение указанному индивидууму эффективного количества молекулы двухцепочечной малой интерферирующей нуклеиновой кислоты (миНК) по п.1.
8. Способ по п.6, где состояние представляет собой инфекцию HBV.
9. Способ по п.6, где состояние представляет собой печеночноклеточную карциному.
10. Набор, содержащий двухцепочечную малую интерферирующую нуклеиновую кислоту (миНК) по п.1.
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US37455510P | 2010-08-17 | 2010-08-17 | |
US61/374,555 | 2010-08-17 |
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RU2013111850A Division RU2624045C2 (ru) | 2010-08-17 | 2011-08-12 | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
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RU2017121299A true RU2017121299A (ru) | 2019-01-29 |
RU2017121299A3 RU2017121299A3 (ru) | 2021-01-26 |
RU2745848C2 RU2745848C2 (ru) | 2021-04-01 |
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RU2013111850A RU2624045C2 (ru) | 2010-08-17 | 2011-08-12 | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
RU2017121299A RU2745848C2 (ru) | 2010-08-17 | 2011-08-12 | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
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RU2013111850A RU2624045C2 (ru) | 2010-08-17 | 2011-08-12 | ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК) |
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US (5) | US9029341B2 (ru) |
EP (3) | EP3587574B1 (ru) |
JP (5) | JP2013537423A (ru) |
KR (2) | KR102413007B1 (ru) |
CN (2) | CN108676800B (ru) |
AU (1) | AU2011292261B2 (ru) |
CA (1) | CA2807307C (ru) |
DK (1) | DK2606134T3 (ru) |
HR (1) | HRP20191232T1 (ru) |
HU (1) | HUE044815T2 (ru) |
LT (1) | LT2606134T (ru) |
RU (2) | RU2624045C2 (ru) |
SI (1) | SI2606134T1 (ru) |
WO (1) | WO2012024170A2 (ru) |
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- 2019-07-10 HR HRP20191232 patent/HRP20191232T1/hr unknown
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2021
- 2021-07-27 JP JP2021122646A patent/JP2021176318A/ja active Pending
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2023
- 2023-01-18 JP JP2023006010A patent/JP2023052480A/ja active Pending
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