DK1019392T3 - Tricykliske amider anvendelige til inhibering af G-proteinfunktion og til behandling af proliferative sygdomme - Google Patents

Tricykliske amider anvendelige til inhibering af G-proteinfunktion og til behandling af proliferative sygdomme

Info

Publication number
DK1019392T3
DK1019392T3 DK96944779T DK96944779T DK1019392T3 DK 1019392 T3 DK1019392 T3 DK 1019392T3 DK 96944779 T DK96944779 T DK 96944779T DK 96944779 T DK96944779 T DK 96944779T DK 1019392 T3 DK1019392 T3 DK 1019392T3
Authority
DK
Denmark
Prior art keywords
inhibiting
proliferative diseases
protein function
treating proliferative
amides useful
Prior art date
Application number
DK96944779T
Other languages
English (en)
Inventor
Ronald J Doll
Joseph M Kelly
F George Njoroge
Alan K Mallams
Stacy W Remiszewski
Arthur G Taveras
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1019392T3 publication Critical patent/DK1019392T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK96944779T 1995-12-22 1996-12-19 Tricykliske amider anvendelige til inhibering af G-proteinfunktion og til behandling af proliferative sygdomme DK1019392T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57795195A 1995-12-22 1995-12-22
US61576096A 1996-03-13 1996-03-13

Publications (1)

Publication Number Publication Date
DK1019392T3 true DK1019392T3 (da) 2006-03-20

Family

ID=27077386

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96944779T DK1019392T3 (da) 1995-12-22 1996-12-19 Tricykliske amider anvendelige til inhibering af G-proteinfunktion og til behandling af proliferative sygdomme

Country Status (24)

Country Link
EP (2) EP1380581A1 (da)
JP (1) JP3193725B2 (da)
KR (1) KR100295224B1 (da)
CN (1) CN1326847C (da)
AR (1) AR005152A1 (da)
AT (1) ATE309238T1 (da)
AU (1) AU730194B2 (da)
BR (1) BR9612203A (da)
CA (2) CA2358394C (da)
CZ (1) CZ292791B6 (da)
DE (1) DE69635424T2 (da)
DK (1) DK1019392T3 (da)
ES (1) ES2248826T3 (da)
HK (1) HK1025571A1 (da)
HU (1) HU228352B1 (da)
IL (1) IL125062A (da)
MX (1) MX9804956A (da)
MY (1) MY119007A (da)
NO (1) NO318232B1 (da)
NZ (1) NZ326035A (da)
PL (1) PL185597B1 (da)
SK (1) SK86198A3 (da)
TW (1) TW350844B (da)
WO (1) WO1997023478A1 (da)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
US5925757A (en) * 1996-07-26 1999-07-20 Schering Corporation Method for preparing carboxamides
AU3732197A (en) * 1996-07-26 1998-02-20 Schering Corporation Method for preparing substituted 1-piperidinecarboxamide derivatives
US5994364A (en) 1996-09-13 1999-11-30 Schering Corporation Tricyclic antitumor farnesyl protein transferase inhibitors
US5945429A (en) * 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6030982A (en) * 1996-09-13 2000-02-29 Schering Corporationm Compounds useful for inhibition of farnesyl protein transferase
US6040305A (en) * 1996-09-13 2000-03-21 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6071907A (en) * 1996-09-13 2000-06-06 Schering Corporation Tricyclic compounds useful as FPT inhibitors
US5985879A (en) * 1996-09-13 1999-11-16 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
CA2266014A1 (en) * 1996-09-13 1998-03-19 Schering Corporation Tricyclic compounds useful for inhibition of farnesyl protein transferase
KR20000036120A (ko) * 1996-09-13 2000-06-26 둘락 노먼 씨. 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제
SK33299A3 (en) * 1996-09-13 2000-06-12 Schering Corp Tricyclic compounds useful for inhibition of farnesyl protein transferase
CA2265764A1 (en) * 1996-09-13 1998-03-19 Schering Corporation Tricyclic compounds useful as fpt inhibitors
EP0931079B1 (en) * 1996-09-13 2001-11-21 Schering Corporation Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
EP0929544B1 (en) * 1996-09-13 2004-11-10 Schering Corporation Tricyclic antitumor compounds being farnesyl protein transferase inhibitors
US5861395A (en) * 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
US5958890A (en) * 1996-09-13 1999-09-28 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6130229A (en) * 1996-10-09 2000-10-10 Schering Corporation Tricyclic compounds having activity as RAS-FPT inhibitors
ATE361668T1 (de) * 1997-02-18 2007-06-15 Canji Inc Kombinierte tumor suppressor-gen-therapie und chemotherapie bei der neoplasmabehandlung
US20030060434A1 (en) 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US5760232A (en) * 1997-06-16 1998-06-02 Schering Corporation Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
US6576639B1 (en) 1997-06-17 2003-06-10 Schering Corporation Compounds for the inhibition of farnesyl protein transferase
US6228865B1 (en) 1997-06-17 2001-05-08 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6051582A (en) * 1997-06-17 2000-04-18 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6159984A (en) 1997-06-17 2000-12-12 Schering Corporation Farnesyl protein transferase inhibitors
US6239140B1 (en) 1997-06-17 2001-05-29 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6358968B1 (en) 1997-06-17 2002-03-19 Schering Corporation N-substituted urea inhibitors of farnesyl-protein transferase
US6225322B1 (en) 1997-06-17 2001-05-01 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
IL133388A0 (en) * 1997-06-17 2001-04-30 Schering Corp Bispyrido-cycloheptane compounds useful for inhibition of farnesyl protein transferase
JP2002504150A (ja) * 1997-06-17 2002-02-05 シェーリング コーポレイション ファルネシルタンパク質トランスフェラーゼの新規フェニル置換三環式インヒビター
US6211193B1 (en) 1997-06-17 2001-04-03 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5877177A (en) * 1997-06-17 1999-03-02 Schering Corporation Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6218401B1 (en) 1997-06-17 2001-04-17 Schering Corporation Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
NZ501571A (en) * 1997-06-17 2002-02-01 Schering Corp Novel n-substituted urea inhibitors of farnesyl-protein transferase
IL136460A0 (en) * 1997-12-22 2001-06-14 Schering Corp Molecular dispersion composition with enhanced bioavailability
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
MY137303A (en) * 1997-12-22 2009-01-30 Schering Corp Methods for treating proliferative diseases
US6096757A (en) 1998-12-21 2000-08-01 Schering Corporation Method for treating proliferative diseases
EP1091954B1 (en) * 1998-07-02 2003-03-12 Schering Corporation Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5h-benzo 5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidine
US6706883B1 (en) * 1998-07-02 2004-03-16 Schering Corporation Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine
US6535820B1 (en) * 1998-08-28 2003-03-18 Schering Corporation Crystalline farnesyl protein transferase compositions and methods for use
TW509680B (en) 1998-11-20 2002-11-11 Schering Corp A compound and process for the preparation of tricyclic compound
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6307048B1 (en) 1998-11-20 2001-10-23 Schering Corporation Enantioselective alkylation of tricyclic compounds
EP1131313B1 (en) * 1998-11-20 2003-02-26 Schering Corporation Enantioselective alkylation of tricyclic compounds
US6316462B1 (en) * 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
US7342016B2 (en) * 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US6528523B2 (en) * 2000-11-29 2003-03-04 Schering Corporation Farnesyl protein transferase inhibitors
US20040082588A1 (en) * 2002-09-30 2004-04-29 Schering Corporation Methods for treating disorders of calcium homeostasis
CN100404510C (zh) * 2002-10-03 2008-07-23 先灵公司 三环化合物的对映选择性烷基化
MXPA06001483A (es) 2003-08-07 2006-05-15 Schering Corp Inhibidores novedosos de la proteina farnesil transferasa como agentes antitumorales.
WO2005017160A2 (en) 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
EP1732549A4 (en) * 2004-03-18 2009-11-11 Brigham & Womens Hospital METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2946778A1 (en) 2006-09-22 2015-11-25 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
WO2008054598A2 (en) * 2006-09-29 2008-05-08 Schering Corporation Panel of biomarkers for prediction of fti efficacy
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
GEP20115337B (en) 2007-01-10 2011-11-25 St Di Ricerche Di Biologia Molecolare P Angeletti Spa Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
US8822497B2 (en) 2007-03-01 2014-09-02 Novartis Ag PIM kinase inhibitors and methods of their use
US8293769B2 (en) 2007-05-21 2012-10-23 Novartis Ag CSF-1R inhibitors, compositions, and methods of use
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US20110129549A1 (en) * 2008-04-17 2011-06-02 Liu Julie F Tricyclic benzo[5,6]cyclohepta[1,2-b]pyridine derivatives and uses thereof
JP2012508765A (ja) * 2008-11-13 2012-04-12 リンク・メディスン・コーポレーション ファルネシルトランスフェラーゼ阻害剤を使用するタンパク症の治療
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
JP6073677B2 (ja) 2009-06-12 2017-02-01 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 縮合複素環式化合物およびそれらの使用
MX2012004377A (es) 2009-10-14 2012-06-01 Merck Sharp & Dohme Piperidinas sustituidas que aumentan la actividad de p53 y sus usos.
AU2010343102B2 (en) 2009-12-29 2016-03-24 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US8987275B2 (en) 2010-03-16 2015-03-24 Dana-Farber Cancer Institute, Inc. Indazole compounds and their uses
EP2584903B1 (en) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
EP2601293B1 (en) 2010-08-02 2017-12-06 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
AU2011292261B2 (en) 2010-08-17 2015-05-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
EP3327125B1 (en) 2010-10-29 2020-08-05 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
US20140045832A1 (en) 2011-04-21 2014-02-13 Piramal Enterprises Limited Insulin-Like Growth Factor-1 Receptor Inhibitors
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
CA2856291C (en) 2011-11-17 2020-08-11 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
EP3453762B1 (en) 2012-05-02 2021-04-21 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
MX2015004041A (es) 2012-09-28 2015-07-06 Merck Sharp & Dohme Compuestos novedosos que son inhibidores de erk.
EP2909194A1 (en) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
RU2660349C2 (ru) 2012-11-28 2018-07-05 Мерк Шарп И Доум Корп. Композиции и способы для лечения злокачественной опухоли
US8846657B2 (en) 2012-12-20 2014-09-30 Merck Sharp & Dohme Corp. Substituted imidazopyridines as HDM2 inhibitors
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015058126A1 (en) 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
KR20160072352A (ko) 2014-12-12 2016-06-23 동보씨엠텍산업(주) 저위투입구 믹서로더
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
EP3273966B1 (en) 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
ES2844848T3 (es) 2015-04-21 2021-07-22 Eiger Biopharmaceuticals Inc Composiciones farmacéuticas que comprenden Lonafarnib y Ritonavir
WO2016201370A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
AU2016319125B2 (en) 2015-09-09 2021-04-08 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
CN110650976B (zh) 2017-04-13 2024-04-19 赛罗帕私人有限公司 抗SIRPα抗体
EP3706742B1 (en) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Prmt5 inhibitors
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
JPH11501671A (ja) 1999-02-09
ATE309238T1 (de) 2005-11-15
ES2248826T3 (es) 2006-03-16
EP1019392A1 (en) 2000-07-19
EP1019392B1 (en) 2005-11-09
CA2240846A1 (en) 1997-07-03
MY119007A (en) 2005-03-31
CA2240846C (en) 2002-07-16
CZ193898A3 (cs) 1998-10-14
HK1025571A1 (en) 2000-11-17
NZ326035A (en) 2000-01-28
HUP9903705A3 (en) 2002-04-29
NO318232B1 (no) 2005-02-21
HUP9903705A2 (hu) 2000-05-28
PL185597B1 (pl) 2003-06-30
SK86198A3 (en) 1999-02-11
NO982878D0 (no) 1998-06-19
CA2358394C (en) 2006-05-02
TW350844B (en) 1999-01-21
EP1380581A1 (en) 2004-01-14
KR19990076655A (ko) 1999-10-15
AR005152A1 (es) 1999-04-14
KR100295224B1 (ko) 2001-09-17
IL125062A (en) 2003-11-23
NO982878L (no) 1998-08-24
JP3193725B2 (ja) 2001-07-30
AU1331197A (en) 1997-07-17
BR9612203A (pt) 1999-07-13
DE69635424D1 (de) 2005-12-15
CN1326847C (zh) 2007-07-18
CA2358394A1 (en) 1997-07-03
WO1997023478A1 (en) 1997-07-03
MX9804956A (es) 1998-09-30
HU228352B1 (en) 2013-03-28
AU730194B2 (en) 2001-03-01
PL327312A1 (en) 1998-12-07
DE69635424T2 (de) 2006-08-03
CN1209127A (zh) 1999-02-24
IL125062A0 (en) 1999-01-26
CZ292791B6 (cs) 2003-12-17

Similar Documents

Publication Publication Date Title
DK1019392T3 (da) Tricykliske amider anvendelige til inhibering af G-proteinfunktion og til behandling af proliferative sygdomme
BR9604787A (pt) Compostos tricíclicos utilizáveis para inibição de função de proteína g e para tratamento de doenças proliferativas
NO973836D0 (no) Benzopyran-inneholdende forbindelser og fremgangsmåte for anvendelse derav
DK0881881T3 (da) Antiparasitært præparat til behandling og beskyttelse af kæledyr
DK1095941T3 (da) Fremgangsmåde og krystalformer for 2-methyl-thieno-benzodiazepin
DE69626104D1 (de) Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und zur behandlung von proliferativen erkrankungen
DK0740896T3 (da) Fremgangsmåde og apparat til optimering af anvendelsen af landbrugs-maskiner
DK80593D0 (da) Fremgangsmaade og anlaeg til udvejning af genstandsportioner
FI956225A0 (fi) Apparat foersedd med gaongjaern
DK0729956T3 (da) Benzothi9phenforbindelser, emllemprodukter, præparater og fremgangsmåder
DK1027208T3 (da) Fremgangsmåde og apparat til aktivering af en artikel
DK0839153T3 (da) Fremgangsmåde til fremstilling af peptider og N-carbamoyl-beskyttede peptider
DK0831098T3 (da) Mellemprodukter og fremgangsmåde til fremstilling af olanzapin
DK0635004T3 (da) 4-Diphenylmethylpiperidinderivater og fremgangsmåde til fremstilling deraf
DK0809592T3 (da) Kæde af lukkeclips samt apparat og fremgangsmåde til lukning af clipsene
DE69405421T2 (de) Verstellbares Kettenrad und Komponenten davon
DE69714504D1 (de) Benzothiopene, diese enthaltende Zubereitungen und Verfahren
DK0568072T3 (da) Fremgangsmåde til fremstilling af amidforbindelser og mikroorganisme til anvendelse deri
DK0698337T3 (da) Fremgangsmåde til adskillelse af markafgrøder og iblandinger
DE69739308D1 (de) Chromatographievorrichtung und Chromatographieverfahren
DK135192D0 (da) Fremgangsmaade og apparat til dannelse af ekstruderende enkeltstykker af iscreme og tilsvarende masser
DK0863948T3 (da) Bitumenkompositioner og fremgangsmåde til fremstilling deraf
DK0889879T3 (da) Butadienderivater og fremgangsmåde til fremstilling deraf
DE59710847D1 (de) Verfahren zum Bezahlen von Waren und Dienstleistungen
NO305869B1 (no) FramgangsmÕte og anordning for spredning av vegsalt