MX9804956A - Amidas triciclicas utiles para la inhibicion de la funcion de la proteina -g y para el tratamiento de las enfermedades proliferativas. - Google Patents

Amidas triciclicas utiles para la inhibicion de la funcion de la proteina -g y para el tratamiento de las enfermedades proliferativas.

Info

Publication number
MX9804956A
MX9804956A MX9804956A MX9804956A MX9804956A MX 9804956 A MX9804956 A MX 9804956A MX 9804956 A MX9804956 A MX 9804956A MX 9804956 A MX9804956 A MX 9804956A MX 9804956 A MX9804956 A MX 9804956A
Authority
MX
Mexico
Prior art keywords
inhibition
treatment
proliferative diseases
protein function
amides useful
Prior art date
Application number
MX9804956A
Other languages
English (en)
Inventor
Ronald J Doll
Joseph M Kelly
F George Njoroge
Alan K Mallams
Stacy W Remiszewski
Arthur G Taveras
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9804956A publication Critical patent/MX9804956A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se presentan compuestos novedosos de conformidad con las formulas (1.0), (4.0), (22,0), (27.0), (32.0) y (39.0). Se presentan también métodos para inhibir el crecimiento anormal de células, para inhibir la farnesilproteintransferasa y para el tratamiento de cánceres usando los compuestos novedosos.
MX9804956A 1995-12-22 1998-06-19 Amidas triciclicas utiles para la inhibicion de la funcion de la proteina -g y para el tratamiento de las enfermedades proliferativas. MX9804956A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57795195A 1995-12-22 1995-12-22
US61576096A 1996-03-13 1996-03-13

Publications (1)

Publication Number Publication Date
MX9804956A true MX9804956A (es) 1998-09-30

Family

ID=27077386

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804956A MX9804956A (es) 1995-12-22 1998-06-19 Amidas triciclicas utiles para la inhibicion de la funcion de la proteina -g y para el tratamiento de las enfermedades proliferativas.

Country Status (24)

Country Link
EP (2) EP1019392B1 (es)
JP (1) JP3193725B2 (es)
KR (1) KR100295224B1 (es)
CN (1) CN1326847C (es)
AR (1) AR005152A1 (es)
AT (1) ATE309238T1 (es)
AU (1) AU730194B2 (es)
BR (1) BR9612203A (es)
CA (2) CA2240846C (es)
CZ (1) CZ292791B6 (es)
DE (1) DE69635424T2 (es)
DK (1) DK1019392T3 (es)
ES (1) ES2248826T3 (es)
HK (1) HK1025571A1 (es)
HU (1) HU228352B1 (es)
IL (1) IL125062A (es)
MX (1) MX9804956A (es)
MY (1) MY119007A (es)
NO (1) NO318232B1 (es)
NZ (1) NZ326035A (es)
PL (1) PL185597B1 (es)
SK (1) SK86198A3 (es)
TW (1) TW350844B (es)
WO (1) WO1997023478A1 (es)

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Also Published As

Publication number Publication date
TW350844B (en) 1999-01-21
EP1380581A1 (en) 2004-01-14
BR9612203A (pt) 1999-07-13
HUP9903705A2 (hu) 2000-05-28
WO1997023478A1 (en) 1997-07-03
HU228352B1 (en) 2013-03-28
HK1025571A1 (en) 2000-11-17
SK86198A3 (en) 1999-02-11
CA2358394C (en) 2006-05-02
HUP9903705A3 (en) 2002-04-29
JP3193725B2 (ja) 2001-07-30
CA2358394A1 (en) 1997-07-03
NO318232B1 (no) 2005-02-21
EP1019392A1 (en) 2000-07-19
ES2248826T3 (es) 2006-03-16
CZ193898A3 (cs) 1998-10-14
CZ292791B6 (cs) 2003-12-17
NO982878D0 (no) 1998-06-19
CN1209127A (zh) 1999-02-24
DE69635424D1 (de) 2005-12-15
AR005152A1 (es) 1999-04-14
PL327312A1 (en) 1998-12-07
NZ326035A (en) 2000-01-28
PL185597B1 (pl) 2003-06-30
IL125062A (en) 2003-11-23
MY119007A (en) 2005-03-31
AU730194B2 (en) 2001-03-01
ATE309238T1 (de) 2005-11-15
AU1331197A (en) 1997-07-17
KR19990076655A (ko) 1999-10-15
EP1019392B1 (en) 2005-11-09
KR100295224B1 (ko) 2001-09-17
DK1019392T3 (da) 2006-03-20
CA2240846C (en) 2002-07-16
JPH11501671A (ja) 1999-02-09
NO982878L (no) 1998-08-24
IL125062A0 (en) 1999-01-26
DE69635424T2 (de) 2006-08-03
CA2240846A1 (en) 1997-07-03
CN1326847C (zh) 2007-07-18

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