MX9707232A - Compuestos triciclicos de amida y urea, utiles para la inhibicion de la funcion de la proteina g y para el tratamiento de enfermedades proliferativas. - Google Patents
Compuestos triciclicos de amida y urea, utiles para la inhibicion de la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.Info
- Publication number
- MX9707232A MX9707232A MX9707232A MX9707232A MX9707232A MX 9707232 A MX9707232 A MX 9707232A MX 9707232 A MX9707232 A MX 9707232A MX 9707232 A MX9707232 A MX 9707232A MX 9707232 A MX9707232 A MX 9707232A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibition
- treatment
- compounds useful
- proliferative diseases
- protein function
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevos compuestos de la Formula (7.0a), (7.0b) o (7.0c). Se describe también un método para inhibir la funcion Ras y por lo tanto para inhibir el desarrollo normal de células. El método comprende administrar un compuesto que tiene la formula (7.0a), (7.0b) o (7.0c) a un sistema biologico. En particular, el método inhibe el desarrollo normal de células en un mamífero tal como un ser humano.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08410443 | 1995-03-24 | ||
| US08/410,443 US5700806A (en) | 1995-03-24 | 1995-03-24 | Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| PCT/US1996/003313 WO1996030362A1 (en) | 1995-03-24 | 1996-03-21 | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707232A true MX9707232A (es) | 1997-11-29 |
| MXPA97007232A MXPA97007232A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| TW349097B (en) | 1999-01-01 |
| IL117602A0 (en) | 1996-07-23 |
| DE69634691T2 (de) | 2006-02-23 |
| AR002722A1 (es) | 1998-04-29 |
| EP0815099B1 (en) | 2005-05-04 |
| WO1996030362A1 (en) | 1996-10-03 |
| NZ305137A (en) | 1999-04-29 |
| JP3095781B2 (ja) | 2000-10-10 |
| JPH10505104A (ja) | 1998-05-19 |
| CA2216163A1 (en) | 1996-10-03 |
| CA2216163C (en) | 2001-06-05 |
| US5807852A (en) | 1998-09-15 |
| DE69634691D1 (de) | 2005-06-09 |
| AU5307696A (en) | 1996-10-16 |
| US5700806A (en) | 1997-12-23 |
| HUP9801331A3 (en) | 1999-06-28 |
| AU711238B2 (en) | 1999-10-07 |
| EP0815099A1 (en) | 1998-01-07 |
| HUP9801331A2 (hu) | 1999-05-28 |
| ES2238689T3 (es) | 2005-09-01 |
| ATE294791T1 (de) | 2005-05-15 |
| KR19980703256A (ko) | 1998-10-15 |
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