JOP20170161A1 - عوامل RNAi للعدوى بفيروس التهاب الكبد ب - Google Patents

عوامل RNAi للعدوى بفيروس التهاب الكبد ب

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Publication number
JOP20170161A1
JOP20170161A1 JOP/2017/0161A JOP20170161A JOP20170161A1 JO P20170161 A1 JOP20170161 A1 JO P20170161A1 JO P20170161 A JOP20170161 A JO P20170161A JO P20170161 A1 JOP20170161 A1 JO P20170161A1
Authority
JO
Jordan
Prior art keywords
hepatitis
rnai
virus infection
triggers
rnai agents
Prior art date
Application number
JOP/2017/0161A
Other languages
English (en)
Inventor
H Wakefield Darren
B Rozema David
Li Zhen
J Almeida Lauren
Zhu Rui
L Lewis David
I Wooddell Christine
Pei Tao
D Given Bruce
Original Assignee
Arrowhead Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of JOP20170161A1 publication Critical patent/JOP20170161A1/ar

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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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Abstract

يتعلق الاختراع الحالي بوصف تركيبات وطرق لتثبيط التعبير الجينى عن فيروس التهاب الكبد ب. حيث يتم وصف عوامل تداخل في الحمض RNA(RNAi) لتثبيط التعبير الجينى عن فيروس التهاب الكبد ب. يمكن استهداف عوامل HBV RNAi التي تم الكشف عنها في الطلب الحالي إلى الخلايا، مثل الخلايا الكبدية، على سبيل المثال، باستخدام المركبات الترابطية المستهدفة المترافقة. كما يتم وصف التركيبات الصيدلانية التي تشتمل على واحد أو أكثر من عوامل HBV RNAi اختيارياً مع واحد أو أكثر من العلاجات الإضافية. يوفر توصيل عوامل HBV RNAi إلى الكبد المصاب بالعدوى في الكائن الحي تثبيط للتعبير الجينى HBV وعلاج الأمراض والحالات المرتبطة بالعدوى بفيروس HBV.
JOP/2017/0161A 2016-08-04 2016-08-04 عوامل RNAi للعدوى بفيروس التهاب الكبد ب JOP20170161A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662370754P 2016-08-04 2016-08-04
US201762534733P 2017-07-20 2017-07-20
US201762540639P 2017-08-03 2017-08-03

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JOP20170161A1 true JOP20170161A1 (ar) 2019-01-30

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Application Number Title Priority Date Filing Date
JOP/2017/0161A JOP20170161A1 (ar) 2016-08-04 2016-08-04 عوامل RNAi للعدوى بفيروس التهاب الكبد ب
JOP/2019/0015A JOP20190015A1 (ar) 2016-08-04 2017-06-16 عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب

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JOP/2019/0015A JOP20190015A1 (ar) 2016-08-04 2017-06-16 عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب

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US (5) US10780108B2 (ar)
EP (1) EP3494123A4 (ar)
JP (3) JP7237816B2 (ar)
KR (4) KR102650107B1 (ar)
CN (2) CN109843902B (ar)
AU (2) AU2017306692B2 (ar)
BR (1) BR112019002117A2 (ar)
CA (2) CA3229270A1 (ar)
CL (4) CL2019000278A1 (ar)
CO (1) CO2019002017A2 (ar)
CR (3) CR20220468A (ar)
EC (1) ECSP19015395A (ar)
IL (2) IL264575B2 (ar)
JO (2) JOP20170161A1 (ar)
MA (1) MA45863A (ar)
MX (3) MX2019001493A (ar)
NZ (1) NZ750390A (ar)
PE (1) PE20190567A1 (ar)
PH (1) PH12019500245A1 (ar)
SG (2) SG10201913585SA (ar)
TW (2) TW202018081A (ar)
UY (1) UY37353A (ar)
WO (1) WO2018027106A2 (ar)

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