MX2021006635A - Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas. - Google Patents

Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

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Publication number
MX2021006635A
MX2021006635A MX2021006635A MX2021006635A MX2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A
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Mexico
Prior art keywords
hbv
methods
hepatitis
virus
irna compositions
Prior art date
Application number
MX2021006635A
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English (en)
Inventor
Stuart Milstein
Martin Maier
Vasant Jadhav
Laura Sepp-Lorenzino
Gregory Hinkle
Muthiah Manoharan
Kallanthottathil G Rajeev
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Alnylam Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54542627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2021006635(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2021006635A publication Critical patent/MX2021006635A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a agentes de iARN, por ejemplo, agentes de iARN bicatenarios, que actúan sobre el genoma del virus de la hepatitis B (5 HBV) y métodos para utilizar tales agentes de iARN con el fin de inhibir la expresión de uno o más genes del HBV y métodos para tratar a sujetos que padecen una infección por el HBV y/o un trastorno asociado con el HBV, por ejemplo, una infección crónica de tipo hepatitis B.
MX2021006635A 2014-11-10 2017-05-08 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas. MX2021006635A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077672P 2014-11-10 2014-11-10
US201462077799P 2014-11-10 2014-11-10
US201562137464P 2015-03-24 2015-03-24

Publications (1)

Publication Number Publication Date
MX2021006635A true MX2021006635A (es) 2021-07-07

Family

ID=54542627

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017005958A MX2017005958A (es) 2014-11-10 2015-11-10 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.
MX2021006635A MX2021006635A (es) 2014-11-10 2017-05-08 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017005958A MX2017005958A (es) 2014-11-10 2015-11-10 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

Country Status (23)

Country Link
US (4) US10640770B2 (es)
EP (3) EP3218487B1 (es)
JP (5) JP2017534290A (es)
KR (3) KR20230088857A (es)
CN (4) CN113699151B (es)
AU (3) AU2015346566B2 (es)
BR (2) BR122021001218B1 (es)
CA (2) CA2967408C (es)
CY (1) CY1122520T1 (es)
DK (1) DK3218489T3 (es)
ES (1) ES2761912T3 (es)
HK (1) HK1255502A1 (es)
HR (1) HRP20192177T1 (es)
HU (1) HUE047535T2 (es)
JO (2) JOP20200092A1 (es)
MA (2) MA40851A (es)
MX (2) MX2017005958A (es)
PL (1) PL3218489T3 (es)
PT (1) PT3218489T (es)
SG (3) SG11201703638XA (es)
SI (1) SI3218489T1 (es)
TW (3) TW201628659A (es)
WO (2) WO2016077349A1 (es)

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WO2016077321A1 (en) 2016-05-19
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US20170349900A1 (en) 2017-12-07
CY1122520T1 (el) 2021-01-27
EP3647424A1 (en) 2020-05-06
BR122021001218B1 (pt) 2023-03-14
KR20170077250A (ko) 2017-07-05
KR20230088857A (ko) 2023-06-20
HRP20192177T1 (hr) 2020-02-21
MA40851A (fr) 2017-09-20
CN113699151A (zh) 2021-11-26
CN108064294A (zh) 2018-05-22
TWI769565B (zh) 2022-07-01
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CN113801882A (zh) 2021-12-17
WO2016077349A1 (en) 2016-05-19
JP2017538679A (ja) 2017-12-28
CA2967408A1 (en) 2016-05-19
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TW202237849A (zh) 2022-10-01
BR112017008868A2 (pt) 2018-01-16

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