EA201791014A1 - Композиции на основе irna против вируса гепатита в (hbv) и способы их применения - Google Patents

Композиции на основе irna против вируса гепатита в (hbv) и способы их применения

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Publication number
EA201791014A1
EA201791014A1 EA201791014A EA201791014A EA201791014A1 EA 201791014 A1 EA201791014 A1 EA 201791014A1 EA 201791014 A EA201791014 A EA 201791014A EA 201791014 A EA201791014 A EA 201791014A EA 201791014 A1 EA201791014 A1 EA 201791014A1
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EA
Eurasian Patent Office
Prior art keywords
hbv
virus
methods
based compositions
against hepatitis
Prior art date
Application number
EA201791014A
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English (en)
Other versions
EA039127B1 (ru
Inventor
Грегори Хинкл
Лаура Сепп-Лорензино
Васант Джадхав
Мартин Майер
Стюарт Милстейн
Мутхиах Манохаран
Каллантхоттатхил Г. Раджив
Original Assignee
Элнилэм Фармасьютикалз, Инк.
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Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Priority claimed from PCT/US2015/059916 external-priority patent/WO2016077321A1/en
Publication of EA201791014A1 publication Critical patent/EA201791014A1/ru
Publication of EA039127B1 publication Critical patent/EA039127B1/ru

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Wood Science & Technology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Настоящее изобретение относится к средствам для RNAi, например двухнитевым средствам для RNAi, целенаправленно воздействующим на геном вируса гепатита В (HBV), и к способам применения таких средств для RNAi для ингибирования экспрессии одного или нескольких генов HBV, и к способам лечения субъектов с инфекцией HBV и/или ассоциированным с HBV нарушением, например хронической инфекцией, вызванной вирусом гепатита В.
EA201791014A 2015-03-24 2015-11-10 КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ EA039127B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562137464P 2015-03-24 2015-03-24
PCT/US2015/059916 WO2016077321A1 (en) 2014-11-10 2015-11-10 Hepatitis b virus (hbv) irna compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
EA201791014A1 true EA201791014A1 (ru) 2017-10-31
EA039127B1 EA039127B1 (ru) 2021-12-08

Family

ID=80631230

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202191771A EA202191771A1 (ru) 2015-03-24 2015-11-10 КОМПОЗИЦИИ НА ОСНОВЕ RNAi ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EA201791014A EA039127B1 (ru) 2015-03-24 2015-11-10 КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA202191771A EA202191771A1 (ru) 2015-03-24 2015-11-10 КОМПОЗИЦИИ НА ОСНОВЕ RNAi ПРОТИВ ВИРУСА ГЕПАТИТА В (HBV) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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EA (2) EA202191771A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114340664A (zh) * 2019-06-18 2022-04-12 爱尔兰詹森科学公司 乙型肝炎病毒(HBV)疫苗和靶向HBV的RNAi的组合

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070027099A1 (en) * 2003-05-19 2007-02-01 Lin Marie C Gene therapy of HBV infection via adeno-associated viral vector mediated long term expression of small hairpin RNA (shRNA)
US7067249B2 (en) * 2003-05-19 2006-06-27 The University Of Hong Kong Inhibition of hepatitis B virus (HBV) replication by RNA interference
CN101314047A (zh) * 2007-06-01 2008-12-03 中国科学院微生物研究所 治疗病毒感染的方法及其药物
CN103275971A (zh) * 2008-06-13 2013-09-04 厦门大学 可用于乙型肝炎病毒感染治疗的rna干扰靶点
CA2807307C (en) * 2010-08-17 2021-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
EP3505528B1 (en) * 2011-04-21 2020-11-25 Ionis Pharmaceuticals, Inc. Modulation of hepatitis b virus (hbv) expression
CN103014045B (zh) * 2012-12-30 2014-09-17 中国人民解放军第三军医大学 表达特异性HBV shRNA的重组HBV载体及其构建方法和应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114340664A (zh) * 2019-06-18 2022-04-12 爱尔兰詹森科学公司 乙型肝炎病毒(HBV)疫苗和靶向HBV的RNAi的组合

Also Published As

Publication number Publication date
EA202191771A1 (ru) 2022-01-31
EA039127B1 (ru) 2021-12-08

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