EA201792444A1 - КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ ФАКТОРА XII (ФАКТОРА ХАГЕМАНА) (F12), ПЛАЗМЕННОГО КАЛЛИКРЕИНА B (ФАКТОРА ФЛЕТЧЕРА) 1 (KLKB1) И КИНИНОГЕНА 1 (KNG1) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents

КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ ФАКТОРА XII (ФАКТОРА ХАГЕМАНА) (F12), ПЛАЗМЕННОГО КАЛЛИКРЕИНА B (ФАКТОРА ФЛЕТЧЕРА) 1 (KLKB1) И КИНИНОГЕНА 1 (KNG1) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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EA201792444A1
EA201792444A1 EA201792444A EA201792444A EA201792444A1 EA 201792444 A1 EA201792444 A1 EA 201792444A1 EA 201792444 A EA201792444 A EA 201792444A EA 201792444 A EA201792444 A EA 201792444A EA 201792444 A1 EA201792444 A1 EA 201792444A1
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Prior art keywords
factor
gene
kng1
klkb1
kininogen
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EA201792444A
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English (en)
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Акин Акинк
Грегори Хинкл
Мартин Майер
Джеймс Батлер
Дзингсюань Лю
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Элнилэм Фармасьютикалз, Инк.
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Publication of EA201792444A1 publication Critical patent/EA201792444A1/ru

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Abstract

Настоящее изобретение относится к средствам для RNAi, например к двухнитевым средствам для RNAi, целенаправленно воздействующим на ген плазменного калликреина В (фактора Флетчера) 1 (KLKB1), ген фактора XII (фактора Хагемана (F12) или ген кининогена 1 (KNG1), и к способам применения таких средств для RNAi для ингибирования экспрессии гена KLKB1, гена F12 и/или гена KNG1, и к способам лечения субъектов с наследственным ангионевротическим отеком (HAE) и/или нарушением, ассоциированным с контактным путем активации свертывания крови.
EA201792444A 2015-05-06 2016-05-05 КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ ФАКТОРА XII (ФАКТОРА ХАГЕМАНА) (F12), ПЛАЗМЕННОГО КАЛЛИКРЕИНА B (ФАКТОРА ФЛЕТЧЕРА) 1 (KLKB1) И КИНИНОГЕНА 1 (KNG1) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ EA201792444A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562157890P 2015-05-06 2015-05-06
US201562260887P 2015-11-30 2015-11-30
US201562266958P 2015-12-14 2015-12-14
PCT/US2016/030876 WO2016179342A2 (en) 2015-05-06 2016-05-05 Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna compositions and methods of use thereof

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EA201792444A1 true EA201792444A1 (ru) 2018-06-29

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EA201792444A EA201792444A1 (ru) 2015-05-06 2016-05-05 КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ ФАКТОРА XII (ФАКТОРА ХАГЕМАНА) (F12), ПЛАЗМЕННОГО КАЛЛИКРЕИНА B (ФАКТОРА ФЛЕТЧЕРА) 1 (KLKB1) И КИНИНОГЕНА 1 (KNG1) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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US (4) US20180100150A1 (ru)
EP (1) EP3292201A2 (ru)
JP (4) JP6695902B2 (ru)
KR (1) KR20180002688A (ru)
CN (2) CN108271386B (ru)
AU (3) AU2016257996A1 (ru)
BR (1) BR112017021967A2 (ru)
CA (1) CA2984636A1 (ru)
EA (1) EA201792444A1 (ru)
HK (1) HK1249920A1 (ru)
TW (3) TW202336231A (ru)
UY (1) UY36671A (ru)
WO (1) WO2016179342A2 (ru)

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JP2023512758A (ja) * 2020-02-07 2023-03-29 インテリア セラピューティクス，インコーポレイテッド カリクレイン（ｋｌｋｂ１）遺伝子編集のための組成物および方法
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