UY36671A - COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO - Google Patents

COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO

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Publication number
UY36671A
UY36671A UY0001036671A UY36671A UY36671A UY 36671 A UY36671 A UY 36671A UY 0001036671 A UY0001036671 A UY 0001036671A UY 36671 A UY36671 A UY 36671A UY 36671 A UY36671 A UY 36671A
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Uruguay
Prior art keywords
factor
gene
kng1
methods
plasmatic
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UY0001036671A
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English (en)
Inventor
Maier Martin
Hinkle Gregory
Akinc Akin
Liu Jingxuan
Butler James
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Alnylam Pharmaceuticals Inc
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Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of UY36671A publication Critical patent/UY36671A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

La presente invenciôn se relaciona con agentes de ARM, por ejemplo, agentes de ARM de doble hebra, contra el gen de Calicremna B, Plasmática (Factor de Fletcher) I (KLKBI), el gen del Factor XII (Factor de Hageman (F 12), o el gen del Quininogeno I (KNG1), y métodos para usar dichos agentes de ARNi para inhibir La expresión de un gen KLKB1, un gen F12, y/o un gen KNG1, y métodos para tratar sujetos que tienen un angioedema hereditarlo (HAE) y10 untrastorno asociado con la via do activación por contacto.
UY0001036671A 2015-05-06 2016-05-06 COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO UY36671A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562157890P 2015-05-06 2015-05-06
US201562260887P 2015-11-30 2015-11-30
US201562266958P 2015-12-14 2015-12-14

Publications (1)

Publication Number Publication Date
UY36671A true UY36671A (es) 2016-12-30

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UY0001036671A UY36671A (es) 2015-05-06 2016-05-06 COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO

Country Status (13)

Country Link
US (4) US20180100150A1 (es)
EP (1) EP3292201A2 (es)
JP (4) JP6695902B2 (es)
KR (1) KR20180002688A (es)
CN (2) CN108271386B (es)
AU (3) AU2016257996A1 (es)
BR (1) BR112017021967A2 (es)
CA (1) CA2984636A1 (es)
EA (1) EA201792444A1 (es)
HK (1) HK1249920A1 (es)
TW (3) TWI727948B (es)
UY (1) UY36671A (es)
WO (1) WO2016179342A2 (es)

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CN118562796A (zh) * 2019-01-18 2024-08-30 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
US20240200060A1 (en) * 2019-05-22 2024-06-20 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
US20220315929A1 (en) * 2019-05-24 2022-10-06 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition and conjugate, preparation method therefor and use thereof
BR112022015380A2 (pt) * 2020-02-07 2022-09-27 Intellia Therapeutics Inc Composições e métodos para edição de gene de calicreína (klkb1)
WO2021195574A1 (en) * 2020-03-27 2021-09-30 Alnylam Pharmaceuticals, Inc. Fc FRAGMENT OF IgG RECEPTOR AND TRANSPORTER (FCGRT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
AR124408A1 (es) 2020-12-18 2023-03-22 Ionis Pharmaceuticals Inc Compuestos y métodos para modular el factor xii
WO2023019246A1 (en) * 2021-08-13 2023-02-16 Alnylam Pharmaceuticals, Inc. Factor xii (f12) irna compositions and methods of use thereof
TW202346586A (zh) * 2022-01-28 2023-12-01 大陸商上海舶望製藥有限公司 用於抑制前激肽釋放酶（pkk）蛋白表達的組合物和方法
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US20200131513A1 (en) 2020-04-30
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