UY36671A - COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO - Google Patents
COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMOInfo
- Publication number
- UY36671A UY36671A UY0001036671A UY36671A UY36671A UY 36671 A UY36671 A UY 36671A UY 0001036671 A UY0001036671 A UY 0001036671A UY 36671 A UY36671 A UY 36671A UY 36671 A UY36671 A UY 36671A
- Authority
- UY
- Uruguay
- Prior art keywords
- factor
- gene
- kng1
- methods
- plasmatic
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61P7/10—Antioedematous agents; Diuretics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N2310/34—Spatial arrangement of the modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
Abstract
La presente invenciôn se relaciona con agentes de ARM, por ejemplo, agentes de ARM de doble hebra, contra el gen de Calicremna B, Plasmática (Factor de Fletcher) I (KLKBI), el gen del Factor XII (Factor de Hageman (F 12), o el gen del Quininogeno I (KNG1), y métodos para usar dichos agentes de ARNi para inhibir La expresión de un gen KLKB1, un gen F12, y/o un gen KNG1, y métodos para tratar sujetos que tienen un angioedema hereditarlo (HAE) y10 untrastorno asociado con la via do activación por contacto.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562157890P | 2015-05-06 | 2015-05-06 | |
US201562260887P | 2015-11-30 | 2015-11-30 | |
US201562266958P | 2015-12-14 | 2015-12-14 |
Publications (1)
Publication Number | Publication Date |
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UY36671A true UY36671A (es) | 2016-12-30 |
Family
ID=55971215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001036671A UY36671A (es) | 2015-05-06 | 2016-05-06 | COMPOSICIONES DE ARNi CONTRA Factor XII (FACTOR DE Hageman) (F12),CALICREÍNA B, PLASMÁTICA (FACTOR DE FLETCHER) 1 (KLKB1), Y QUININÓGENO 1 (KNG1) Y MÉTODOS DE USO DE LOS MISMO |
Country Status (13)
Country | Link |
---|---|
US (4) | US20180100150A1 (es) |
EP (1) | EP3292201A2 (es) |
JP (4) | JP6695902B2 (es) |
KR (1) | KR20180002688A (es) |
CN (2) | CN108271386B (es) |
AU (3) | AU2016257996A1 (es) |
BR (1) | BR112017021967A2 (es) |
CA (1) | CA2984636A1 (es) |
EA (1) | EA201792444A1 (es) |
HK (1) | HK1249920A1 (es) |
TW (3) | TW202336231A (es) |
UY (1) | UY36671A (es) |
WO (1) | WO2016179342A2 (es) |
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CN113493789A (zh) | 2015-03-17 | 2021-10-12 | 箭头药业股份有限公司 | 用于抑制因子xii的基因表达的组合物和方法 |
CA2984636A1 (en) | 2015-05-06 | 2016-11-10 | Alnylam Pharmaceuticals, Inc. | Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna compositions and methods of use thereof |
EP3400301A4 (en) * | 2016-01-08 | 2019-11-27 | Alnylam Pharmaceuticals, Inc. | POLYNUCLEOTIDE AGENTS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) AND THEIR METHODS OF USE |
AU2018213379A1 (en) * | 2017-01-30 | 2019-07-18 | Arrowhead Pharmaceuticals Inc. | Compositions and methods for inhibition of factor XII gene expression |
US20200208150A1 (en) * | 2017-07-07 | 2020-07-02 | Alnylam Pharmaceuticals, Inc. | METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOCIATED DISEASES USING iRNA COMPOSITIONS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) |
JP7273417B2 (ja) | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
KR20200091414A (ko) | 2017-12-01 | 2020-07-30 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 이중-가닥 올리고뉴클레오티드, 조성물 및 이중-가닥 올리고뉴클레오티드를 포함하는 접합체, 그의 제조 방법 및 그의 용도 |
EP3719126A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, ASSOCIATED PREPARATION PROCESS AND USE |
JP7365052B2 (ja) | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
KR102617947B1 (ko) | 2017-12-29 | 2023-12-27 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 접합체와 제조 및 그 용도 |
JP2021533800A (ja) | 2018-08-21 | 2021-12-09 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. | 核酸、当該核酸を含む薬物組成物及び複合体ならびにその使用 |
EP3862024A4 (en) | 2018-09-30 | 2022-08-17 | Suzhou Ribo Life Science Co., Ltd. | SHORT INTERFERENT RNA CONJUGATE, METHOD FOR PREPARATION AND USE THEREOF |
WO2020147847A1 (zh) * | 2019-01-18 | 2020-07-23 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
CN113811613B (zh) * | 2019-05-22 | 2024-04-05 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
JP2022534069A (ja) * | 2019-05-24 | 2022-07-27 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体並びに調製方法と使用 |
TW202146030A (zh) * | 2020-02-07 | 2021-12-16 | 美商英特利亞醫療公司 | 用於激肽釋放酶(klkb1)基因編輯之組合物及方法 |
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WO2016179342A3 (en) | 2017-01-12 |
CN115322991A (zh) | 2022-11-11 |
TW202130811A (zh) | 2021-08-16 |
AU2024200717A1 (en) | 2024-04-18 |
WO2016179342A2 (en) | 2016-11-10 |
KR20180002688A (ko) | 2018-01-08 |
CN108271386B (zh) | 2022-07-15 |
JP2020188756A (ja) | 2020-11-26 |
US20210246447A1 (en) | 2021-08-12 |
US20240076664A1 (en) | 2024-03-07 |
AU2016257996A1 (en) | 2017-10-26 |
JP2022141707A (ja) | 2022-09-29 |
TW202336231A (zh) | 2023-09-16 |
JP6695902B2 (ja) | 2020-05-20 |
TWI727948B (zh) | 2021-05-21 |
US20180100150A1 (en) | 2018-04-12 |
CN108271386A (zh) | 2018-07-10 |
JP2018519797A (ja) | 2018-07-26 |
US10934544B2 (en) | 2021-03-02 |
BR112017021967A2 (pt) | 2018-07-31 |
EA201792444A1 (ru) | 2018-06-29 |
HK1249920A1 (zh) | 2018-11-16 |
US20200131513A1 (en) | 2020-04-30 |
TWI806034B (zh) | 2023-06-21 |
CA2984636A1 (en) | 2016-11-10 |
EP3292201A2 (en) | 2018-03-14 |
JP2024037849A (ja) | 2024-03-19 |
TW201704472A (zh) | 2017-02-01 |
AU2021258003A1 (en) | 2021-11-25 |
WO2016179342A9 (en) | 2016-12-08 |
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