UY35582A - COMPOSICIONES DE ARNi DE SERPINA1 Y SUS MÉTODOS DE USO - Google Patents

COMPOSICIONES DE ARNi DE SERPINA1 Y SUS MÉTODOS DE USO

Info

Publication number
UY35582A
UY35582A UY35582A UY35582A UY35582A UY 35582 A UY35582 A UY 35582A UY 35582 A UY35582 A UY 35582A UY 35582 A UY35582 A UY 35582A UY 35582 A UY35582 A UY 35582A
Authority
UY
Uruguay
Prior art keywords
serpina1
methods
arni
compositions
rnai agents
Prior art date
Application number
UY35582A
Other languages
English (en)
Inventor
Sehgal Alfica
Charisse Klaus
Bettencourt Brian
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of UY35582A publication Critical patent/UY35582A/es

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

La invención se relaciona con agentes de ARNi, por ejemplo, agentes de ARNi de doble hebra, que se dirigen contra el gen de Serpina1, y métodos para usar dichos agentes de ARNi para inhibir la expresión de Serpina1 y métodos para tratar a sujetos que tienen una enfermedad asociada a Serpina1, tal como un trastorno de hígado.
UY35582A 2013-05-22 2014-05-22 COMPOSICIONES DE ARNi DE SERPINA1 Y SUS MÉTODOS DE USO UY35582A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361826125P 2013-05-22 2013-05-22
US201361898695P 2013-11-01 2013-11-01
US201461979727P 2014-04-15 2014-04-15
US201461989028P 2014-05-06 2014-05-06

Publications (1)

Publication Number Publication Date
UY35582A true UY35582A (es) 2014-10-31

Family

ID=51934144

Family Applications (1)

Application Number Title Priority Date Filing Date
UY35582A UY35582A (es) 2013-05-22 2014-05-22 COMPOSICIONES DE ARNi DE SERPINA1 Y SUS MÉTODOS DE USO

Country Status (33)

Country Link
US (5) US9574192B2 (es)
EP (2) EP3412774A1 (es)
JP (3) JP6495250B2 (es)
KR (3) KR102295648B1 (es)
CN (2) CN113018307A (es)
AU (2) AU2014268509B2 (es)
BR (1) BR112015029139B1 (es)
CA (1) CA2912826A1 (es)
CL (1) CL2015003441A1 (es)
CY (1) CY1122159T1 (es)
DK (1) DK2999785T3 (es)
DO (1) DOP2015000288A (es)
EA (1) EA038792B1 (es)
ES (1) ES2676146T3 (es)
GT (1) GT201500330A (es)
HK (1) HK1221979A1 (es)
HR (1) HRP20181030T1 (es)
HU (1) HUE038146T2 (es)
IL (3) IL242637B (es)
LT (1) LT2999785T (es)
MX (1) MX2021000656A (es)
MY (1) MY176712A (es)
PE (2) PE20210921A1 (es)
PL (1) PL2999785T3 (es)
PT (1) PT2999785T (es)
RS (1) RS57418B1 (es)
RU (1) RU2015154721A (es)
SG (3) SG11201509712YA (es)
SI (1) SI2999785T1 (es)
TW (2) TW201936624A (es)
UY (1) UY35582A (es)
WO (1) WO2014190137A1 (es)
ZA (1) ZA201509252B (es)

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EP4012031A1 (en) 2013-07-03 2022-06-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded rna
MX2016015126A (es) 2014-05-22 2017-02-23 Alnylam Pharmaceuticals Inc Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas.
TW201620526A (zh) * 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
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RU2754188C2 (ru) 2015-12-07 2021-08-30 Джензим Корпорейшн Способы и композиции для лечения ассоциированного с serpinc1 расстройства
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WO2019100039A1 (en) * 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
CN118685406A (zh) 2018-05-14 2024-09-24 阿尔尼拉姆医药品有限公司 血管紧张素原(AGT)iRNA组合物及其使用方法
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