UY36357A - Composiciones y métodos para la inhibición de la expresión génica de hao1 (hidroxiácido oxidasa 1 (glicolato oxidasa)) - Google Patents

Composiciones y métodos para la inhibición de la expresión génica de hao1 (hidroxiácido oxidasa 1 (glicolato oxidasa))

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Publication number
UY36357A
UY36357A UY0001036357A UY36357A UY36357A UY 36357 A UY36357 A UY 36357A UY 0001036357 A UY0001036357 A UY 0001036357A UY 36357 A UY36357 A UY 36357A UY 36357 A UY36357 A UY 36357A
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UY
Uruguay
Prior art keywords
oxidase
methods
hydroxyacyde
glycolate
inhibition
Prior art date
Application number
UY0001036357A
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English (en)
Inventor
Querbes William
Fitzgerald Kevin
Bettencourt Brian
Liebow Abigail
David V Erbe
Original Assignee
Alnylam Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of UY36357A publication Critical patent/UY36357A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03015—(S)-2-Hydroxy-acid oxidase (1.1.3.15)

Abstract

La invención se refiere a agentes de ARNi, por ejemplo, agentes de ARNi bicatenarios, que se dirigen al gen HAO1 y métodos de uso de tales agentes de ARNi para inhibir la expresión de HAO1 y métodos de tratamiento de sujetos que tienen, por ejemplo, PH1.
UY0001036357A 2014-10-10 2015-10-13 Composiciones y métodos para la inhibición de la expresión génica de hao1 (hidroxiácido oxidasa 1 (glicolato oxidasa)) UY36357A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462062751P 2014-10-10 2014-10-10
US201562147976P 2015-04-15 2015-04-15
US201562214602P 2015-09-04 2015-09-04

Publications (1)

Publication Number Publication Date
UY36357A true UY36357A (es) 2016-11-30

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UY0001036357A UY36357A (es) 2014-10-10 2015-10-13 Composiciones y métodos para la inhibición de la expresión génica de hao1 (hidroxiácido oxidasa 1 (glicolato oxidasa))

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US (3) US10478500B2 (es)
EP (2) EP4039809A1 (es)
JP (3) JP6836988B2 (es)
KR (2) KR102558604B1 (es)
CN (2) CN108064154B (es)
AU (2) AU2015330726B9 (es)
BR (1) BR112017006469A2 (es)
CA (2) CA3187050A1 (es)
CO (1) CO2017004728A2 (es)
CR (1) CR20170190A (es)
CY (1) CY1125364T1 (es)
DK (1) DK3204015T3 (es)
DO (1) DOP2017000094A (es)
EA (1) EA037115B1 (es)
EC (1) ECSP17028310A (es)
ES (1) ES2905889T3 (es)
HR (1) HRP20211971T1 (es)
HU (2) HUE057327T2 (es)
IL (3) IL310466A (es)
JO (2) JOP20200115A1 (es)
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NO (1) NO2022009I1 (es)
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PT (1) PT3204015T (es)
RS (1) RS62854B1 (es)
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SI (1) SI3204015T1 (es)
TN (1) TN2017000125A1 (es)
TW (3) TWI755351B (es)
UA (1) UA126266C2 (es)
UY (1) UY36357A (es)
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