ECSP20024210A - Uso de inhibidores de p38 para reducir la expresión de dux4 - Google Patents

Uso de inhibidores de p38 para reducir la expresión de dux4

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Publication number
ECSP20024210A
ECSP20024210A ECSENADI202024210A ECDI202024210A ECSP20024210A EC SP20024210 A ECSP20024210 A EC SP20024210A EC SENADI202024210 A ECSENADI202024210 A EC SENADI202024210A EC DI202024210 A ECDI202024210 A EC DI202024210A EC SP20024210 A ECSP20024210 A EC SP20024210A
Authority
EC
Ecuador
Prior art keywords
dux4
expression
reduce
inhibitors
methods
Prior art date
Application number
ECSENADI202024210A
Other languages
English (en)
Inventor
Ning Shen
Owen Brendan Wallace
Lucienne V Ronco
Angela Marie Cacace
Aaron Nakwon Chang
Alan Scott Robertson
Soto Luis Gustavo Alejandro Rojas
Lorin A Thompson
Original Assignee
Fulcrum Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fulcrum Therapeutics Inc filed Critical Fulcrum Therapeutics Inc
Publication of ECSP20024210A publication Critical patent/ECSP20024210A/es

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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Abstract

La presente invención hace referencia a composiciones y métodos para inhibir la cinasa p38 para reducir la expresión de proteínas y genes de DUX4 y los genes posteriores regulados por DUX4. La presente invención hace referencia además a métodos para el tratamiento de pacientes que padecen de enfermedades y trastornos asociados con un aumento de la expresión de DUX4 o la expresión de una forma anómala de DUX4, tal como distrofia muscular facioescapulohumeral (FSHD).
ECSENADI202024210A 2017-10-05 2020-05-04 Uso de inhibidores de p38 para reducir la expresión de dux4 ECSP20024210A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762568754P 2017-10-05 2017-10-05
US201762568673P 2017-10-05 2017-10-05
US201862682563P 2018-06-08 2018-06-08
US201862682565P 2018-06-08 2018-06-08

Publications (1)

Publication Number Publication Date
ECSP20024210A true ECSP20024210A (es) 2020-07-31

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Application Number Title Priority Date Filing Date
ECSENADI202024210A ECSP20024210A (es) 2017-10-05 2020-05-04 Uso de inhibidores de p38 para reducir la expresión de dux4

Country Status (28)

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US (5) US11479770B2 (es)
EP (3) EP3692144A1 (es)
JP (5) JP7012152B2 (es)
KR (2) KR20200067170A (es)
CN (4) CN111868237A (es)
AU (2) AU2018346712B2 (es)
BR (2) BR112020006169A2 (es)
CA (4) CA3128468A1 (es)
CL (3) CL2020000911A1 (es)
CO (2) CO2020005351A2 (es)
DK (1) DK3691620T3 (es)
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