BR0313961A - Processos e intermediários para preparar triazolo-piridinas - Google Patents
Processos e intermediários para preparar triazolo-piridinasInfo
- Publication number
- BR0313961A BR0313961A BR0313961-1A BR0313961A BR0313961A BR 0313961 A BR0313961 A BR 0313961A BR 0313961 A BR0313961 A BR 0313961A BR 0313961 A BR0313961 A BR 0313961A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- pyridines
- intermediates
- processes
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
"PROCESSOS E INTERMEDIáRIOS PARA PREPARAR TRIAZOLO-PIRIDINAS". A presente invenção refere-se com um novo processo de preparar triazolo-piridinas de fórmula I em que R^ 1^ é selecionado do grupo composto por hidrogênio, (C~ 1~-C~ 6~)alquila ou outros substituintes adequados; R^ 3^ é selecionado do grupo composto por hidrogênio, (C~ 1~-C~ 6~)alquila ou outros substituintes adequados; s é um número inteiro de 0-5; R^ 4^ é hidrogênio ou um substituinte adequado; e com intermediários para a sua preparação. Os compostos preparados de acordo com os métodos da presente invenção são inibidores potentes das cinases MAP, preferencialmente da cinase p38. Aqueles são úteis no tratamento de inflamação, osteoartrite, artrite reumatóide, câncer, reperfusão ou isquemia no acidente vascular cerebral ou ataque cardíaco, doenças auto-imunes e outras perturbações.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40708502P | 2002-08-30 | 2002-08-30 | |
PCT/IB2003/003669 WO2004020438A2 (en) | 2002-08-30 | 2003-08-18 | Novel processes and intermediates for preparing triazolo-pyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313961A true BR0313961A (pt) | 2005-07-19 |
Family
ID=31978416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313961-1A BR0313961A (pt) | 2002-08-30 | 2003-08-18 | Processos e intermediários para preparar triazolo-piridinas |
Country Status (10)
Country | Link |
---|---|
US (1) | US20040053959A1 (pt) |
EP (1) | EP1537107A2 (pt) |
JP (1) | JP2006508914A (pt) |
AR (1) | AR041192A1 (pt) |
AU (1) | AU2003253188A1 (pt) |
BR (1) | BR0313961A (pt) |
CA (1) | CA2496812A1 (pt) |
MX (1) | MXPA05002123A (pt) |
TW (1) | TW200413367A (pt) |
WO (1) | WO2004020438A2 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004072072A1 (en) * | 2003-02-14 | 2004-08-26 | Pfizer Products Inc. | Triazolo-pyridines as anti-inflammatory compounds |
EP1781655A2 (en) * | 2004-08-18 | 2007-05-09 | Pharmacia & Upjohn Company LLC | Triazolopyridine compounds useful for the treatment of inflammation |
US7579360B2 (en) * | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
US7572807B2 (en) * | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
TW200817410A (en) | 2006-08-07 | 2008-04-16 | Incyte Corp | Triazolotriazines as kinase inhibitors |
ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
GEP20125658B (en) | 2006-11-22 | 2012-10-10 | Incyte Corp | Imidazotriazines and imidazo pyrimidines as kinase inhibitors |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
HUE034716T2 (hu) | 2008-05-21 | 2018-02-28 | Incyte Holdings Corp | 2-Fluor-N-metil-4-[7-(kinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamid sói és eljárások ezek elõállítására |
EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
JP5714030B2 (ja) | 2010-02-03 | 2015-05-07 | インサイト コーポレーションIncyte Corporation | C−Met阻害剤としてのイミダゾ[1,2−b][1,2,4]トリアジン |
JP5957526B2 (ja) | 2011-09-15 | 2016-07-27 | ノバルティス アーゲー | チロシンキナーゼとしての6−置換3−(キノリン−6−イルチオ)−[1,2,4]トリアゾロ[4,3−a]ピラジン |
CA3128468A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
WO2024054476A1 (en) * | 2022-09-09 | 2024-03-14 | Fmc Corporation | New processes for synthesis of (3-chloro-2-pyridyl)hydrazine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69433501T2 (de) * | 1993-11-08 | 2004-11-04 | Smithkline Beecham Corp. | Oxazole zur behandlung von zytokinvermittelten erkrankungen |
ES2205167T3 (es) * | 1996-01-11 | 2004-05-01 | Smithkline Beecham Corporation | Nuevos compuestos de imidazol sustituidos. |
US6207687B1 (en) * | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
US6469018B1 (en) * | 1999-01-08 | 2002-10-22 | Smithkline Beecham Corporation | Compounds |
CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
OA12552A (en) * | 2001-03-09 | 2006-06-06 | Pfizer Prod Inc | Triazolopyridines as anti-inflammatory agents. |
-
2003
- 2003-08-18 BR BR0313961-1A patent/BR0313961A/pt not_active IP Right Cessation
- 2003-08-18 JP JP2004532401A patent/JP2006508914A/ja active Pending
- 2003-08-18 MX MXPA05002123A patent/MXPA05002123A/es unknown
- 2003-08-18 EP EP03791115A patent/EP1537107A2/en not_active Withdrawn
- 2003-08-18 AU AU2003253188A patent/AU2003253188A1/en not_active Abandoned
- 2003-08-18 WO PCT/IB2003/003669 patent/WO2004020438A2/en not_active Application Discontinuation
- 2003-08-18 CA CA002496812A patent/CA2496812A1/en not_active Abandoned
- 2003-08-27 US US10/649,247 patent/US20040053959A1/en not_active Abandoned
- 2003-08-28 AR ARP030103117A patent/AR041192A1/es unknown
- 2003-08-29 TW TW092123949A patent/TW200413367A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1537107A2 (en) | 2005-06-08 |
AU2003253188A1 (en) | 2004-03-19 |
AU2003253188A8 (en) | 2004-03-19 |
WO2004020438A3 (en) | 2004-07-22 |
JP2006508914A (ja) | 2006-03-16 |
CA2496812A1 (en) | 2004-03-11 |
WO2004020438A2 (en) | 2004-03-11 |
MXPA05002123A (es) | 2005-06-06 |
US20040053959A1 (en) | 2004-03-18 |
AR041192A1 (es) | 2005-05-04 |
TW200413367A (en) | 2004-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A,5A,6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010. |