DOP2002000349A - Nuevos compuestos antiinflamatorios de bencimidazol - Google Patents
Nuevos compuestos antiinflamatorios de bencimidazolInfo
- Publication number
- DOP2002000349A DOP2002000349A DO2002000349A DO2002000349A DOP2002000349A DO P2002000349 A DOP2002000349 A DO P2002000349A DO 2002000349 A DO2002000349 A DO 2002000349A DO 2002000349 A DO2002000349 A DO 2002000349A DO P2002000349 A DOP2002000349 A DO P2002000349A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- bencimidazol
- alkyl
- new
- hydrogen
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a nuevas triazolo piridinas de fórmula I en la que Het es un heterociclo de 5 miembros opcionalmente sustituido que contiene de uno a dos heteroátomos seleccionados entre nitrógeno, azufre y oxígeno, debiendo ser al menos uno de dichos heteroátomos nitrógeno; R2 se selecciona entre el grupo compuesto por hidrógeno, alquilo C1-C6 u otros sustituyentes adecuados; R3 se selecciona entre el grupo compuesto por hidrógeno, alquilo C1-C6 u otros sustituyentes adecuados; s es un número entero de 0-5; a intermedios para su preparación, a composiciones farmacéuticas que las contienen y a su uso en medicina. Los compuestos de la presente invención son potentes inhibidores de las MAP quinasas, preferiblemente de la quinasa p3a. son utiles en el tratamiento de la inflamación,, la osteoartritis, la artritis reumatoide, el cancer la reperfusion o isquemia en apoplejia o en un ataque cardiaco, enfermedades autoinmunes y otros trastornos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27479101P | 2001-03-09 | 2001-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2002000349A true DOP2002000349A (es) | 2002-10-15 |
Family
ID=23049627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2002000349A DOP2002000349A (es) | 2001-03-09 | 2002-02-28 | Nuevos compuestos antiinflamatorios de bencimidazol |
Country Status (17)
Country | Link |
---|---|
US (1) | US7056918B2 (es) |
EP (1) | EP1370557B1 (es) |
JP (1) | JP2004526727A (es) |
AP (1) | AP2002002460A0 (es) |
AT (1) | ATE309997T1 (es) |
BR (1) | BR0207957A (es) |
CA (1) | CA2440211A1 (es) |
DE (1) | DE60207390T2 (es) |
DO (1) | DOP2002000349A (es) |
ES (1) | ES2251582T3 (es) |
GT (1) | GT200200043A (es) |
MX (1) | MXPA03008142A (es) |
PA (1) | PA8540901A1 (es) |
PE (1) | PE20030200A1 (es) |
TN (1) | TNSN02021A1 (es) |
UY (1) | UY27198A1 (es) |
WO (1) | WO2002072576A1 (es) |
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US5756499A (en) | 1996-01-11 | 1998-05-26 | Smithkline Beecham Corporation | Substituted imidazole compounds |
ZA97175B (en) | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
TW517055B (en) * | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
JP2002516325A (ja) | 1998-05-26 | 2002-06-04 | スミスクライン・ビーチャム・コーポレイション | 新規な置換イミダゾール化合物 |
US6207687B1 (en) * | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
WO2000010563A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
US6350744B1 (en) | 1998-11-20 | 2002-02-26 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
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JP2002534385A (ja) | 1999-01-08 | 2002-10-15 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
-
2002
- 2002-01-30 BR BR0207957-7A patent/BR0207957A/pt not_active IP Right Cessation
- 2002-01-30 ES ES02716257T patent/ES2251582T3/es not_active Expired - Lifetime
- 2002-01-30 WO PCT/IB2002/000334 patent/WO2002072576A1/en active IP Right Grant
- 2002-01-30 CA CA002440211A patent/CA2440211A1/en not_active Abandoned
- 2002-01-30 JP JP2002571492A patent/JP2004526727A/ja not_active Withdrawn
- 2002-01-30 EP EP02716257A patent/EP1370557B1/en not_active Expired - Lifetime
- 2002-01-30 AP APAP/P/2002/002460A patent/AP2002002460A0/en unknown
- 2002-01-30 MX MXPA03008142A patent/MXPA03008142A/es active IP Right Grant
- 2002-01-30 DE DE60207390T patent/DE60207390T2/de not_active Expired - Fee Related
- 2002-01-30 AT AT02716257T patent/ATE309997T1/de not_active IP Right Cessation
- 2002-02-28 DO DO2002000349A patent/DOP2002000349A/es unknown
- 2002-03-05 GT GT200200043A patent/GT200200043A/es unknown
- 2002-03-06 UY UY27198A patent/UY27198A1/es not_active Application Discontinuation
- 2002-03-06 PE PE2002000180A patent/PE20030200A1/es not_active Application Discontinuation
- 2002-03-08 PA PA20028540901A patent/PA8540901A1/es unknown
- 2002-03-08 TN TNTNSN02021A patent/TNSN02021A1/fr unknown
- 2002-03-11 US US10/094,717 patent/US7056918B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1370557B1 (en) | 2005-11-16 |
EP1370557A1 (en) | 2003-12-17 |
UY27198A1 (es) | 2002-11-29 |
US20030092749A1 (en) | 2003-05-15 |
CA2440211A1 (en) | 2002-09-19 |
US7056918B2 (en) | 2006-06-06 |
GT200200043A (es) | 2003-02-11 |
DE60207390T2 (de) | 2006-07-20 |
WO2002072576A1 (en) | 2002-09-19 |
AP2002002460A0 (en) | 2002-06-30 |
ES2251582T3 (es) | 2006-05-01 |
JP2004526727A (ja) | 2004-09-02 |
MXPA03008142A (es) | 2003-12-12 |
DE60207390D1 (de) | 2005-12-22 |
TNSN02021A1 (fr) | 2005-12-23 |
BR0207957A (pt) | 2004-02-25 |
PE20030200A1 (es) | 2003-03-12 |
ATE309997T1 (de) | 2005-12-15 |
PA8540901A1 (es) | 2002-10-28 |
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