TR200103286T2 - Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri - Google Patents

Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri

Info

Publication number
TR200103286T2
TR200103286T2 TR2001/03286T TR200103286T TR200103286T2 TR 200103286 T2 TR200103286 T2 TR 200103286T2 TR 2001/03286 T TR2001/03286 T TR 2001/03286T TR 200103286 T TR200103286 T TR 200103286T TR 200103286 T2 TR200103286 T2 TR 200103286T2
Authority
TR
Turkey
Prior art keywords
substituted
alkyl
progesterone receptor
receptor modulators
alkenyl
Prior art date
Application number
TR2001/03286T
Other languages
English (en)
Inventor
Zhang Puwen
A. Terefenko Eugene
A. Fletcher Horace Iii
Fensome Anderw
E. Wrobel Jay
Zhi Lin
K. Jones Todd
M.Tegley Christopher
P. Edwards James
Original Assignee
American Home Products Corporation
Ligand Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,633 external-priority patent/US6509334B1/en
Application filed by American Home Products Corporation, Ligand Pharmaceuticals, Inc. filed Critical American Home Products Corporation
Publication of TR200103286T2 publication Critical patent/TR200103286T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Bulus Formül (I) bilesiklerini veya bunlarin farmasötik olarak uygun tuzlarini, ve ayni zamanda projesteron reseptörü antagonistleri olarak bilesiklerin kullanilmasiyla farmasötik bilesimler ve yöntemler saglamaktadir, ki burada R1 ve R2 ayri sübtitüe gruplari olabilir veya spirosiklik veya heterospirosiklik halkalar olusturacak sekilde birlesik olabilir; R3 asagidakilerden seçilir: H, OH, NH2, C1-C6 alkil, sübstitüe edilmis C1-C6 alkil, C3-C6 alkenil, sübstitüe edilmis C1-C6 alkenil, alkinil, veya sübstitüe edilmis alkinil, CORc;Rc asagidakilerden seçilir: H, C1-C3 alkil, sübstitüe edilmis C1-C3 alkil , aril, sübstitüe edilmis aril, C1-C3 alkoksi, DEVAMI VAR
TR2001/03286T 1999-05-04 2000-05-01 Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri TR200103286T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18301299P 1999-05-04 1999-05-04
US09/552,633 US6509334B1 (en) 1999-05-04 2000-04-19 Cyclocarbamate derivatives as progesterone receptor modulators

Publications (1)

Publication Number Publication Date
TR200103286T2 true TR200103286T2 (tr) 2002-07-22

Family

ID=26878647

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03286T TR200103286T2 (tr) 1999-05-04 2000-05-01 Projesteron reseptörü modülatörleri olarak siklokarbamat türevleri

Country Status (19)

Country Link
EP (1) EP1173426A1 (tr)
JP (1) JP2002543193A (tr)
KR (1) KR20010114250A (tr)
CN (1) CN1145618C (tr)
AU (1) AU766428B2 (tr)
BG (1) BG106079A (tr)
BR (1) BR0010213A (tr)
CA (1) CA2371726A1 (tr)
CZ (1) CZ20013951A3 (tr)
EA (1) EA004512B1 (tr)
HU (1) HUP0201609A3 (tr)
IL (1) IL146280A0 (tr)
MX (1) MXPA01011286A (tr)
NO (1) NO321361B1 (tr)
NZ (1) NZ515355A (tr)
PL (1) PL351127A1 (tr)
SG (1) SG114650A1 (tr)
SK (1) SK15912001A3 (tr)
TR (1) TR200103286T2 (tr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582755B2 (en) * 2004-04-27 2009-09-01 Wyeth Cyanopyrrole-containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
WO2006077821A1 (ja) * 2005-01-19 2006-07-27 Dainippon Sumitomo Pharma Co., Ltd. アルドステロン受容体調節剤としての芳香族スルホン化合物
EP2210880B1 (en) * 2007-10-05 2015-08-26 Msd K.K. Benzoxazinone derivatives
CN111925353B (zh) * 2020-08-31 2022-04-08 苏州大学附属第二医院 一种2-噻吩甲腈的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
NZ300739A (en) * 1994-12-22 2000-05-26 Ligand Pharm Inc Steroid receptor modulator compounds
CA2268953A1 (en) * 1996-10-02 1998-04-09 Du Pont Pharmaceuticals Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same

Also Published As

Publication number Publication date
CA2371726A1 (en) 2000-11-09
HUP0201609A3 (en) 2002-12-28
MXPA01011286A (es) 2003-07-14
EP1173426A1 (en) 2002-01-23
CN1145618C (zh) 2004-04-14
AU766428B2 (en) 2003-10-16
EA004512B1 (ru) 2004-04-29
IL146280A0 (en) 2002-07-25
EA200101176A1 (ru) 2002-04-25
KR20010114250A (ko) 2001-12-31
SG114650A1 (en) 2005-09-28
NZ515355A (en) 2004-02-27
NO20015378L (no) 2002-01-03
CN1349517A (zh) 2002-05-15
SK15912001A3 (sk) 2002-06-04
HUP0201609A2 (en) 2002-08-28
PL351127A1 (en) 2003-03-24
CZ20013951A3 (cs) 2002-05-15
NO321361B1 (no) 2006-05-02
NO20015378D0 (no) 2001-11-02
BR0010213A (pt) 2002-02-19
AU4688600A (en) 2000-11-17
BG106079A (en) 2002-05-31
JP2002543193A (ja) 2002-12-17

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