BG106079A - Cyclocarbamate derivatives as progesterone receptor modulators - Google Patents

Cyclocarbamate derivatives as progesterone receptor modulators

Info

Publication number
BG106079A
BG106079A BG106079A BG10607901A BG106079A BG 106079 A BG106079 A BG 106079A BG 106079 A BG106079 A BG 106079A BG 10607901 A BG10607901 A BG 10607901A BG 106079 A BG106079 A BG 106079A
Authority
BG
Bulgaria
Prior art keywords
substituted
alkyl
alkoxy
aminoalkyl
alkynyl
Prior art date
Application number
BG106079A
Other languages
Bulgarian (bg)
Inventor
Puwen Zhang
Eugene Teferenko
Andrew Fensome
Jay Wrobel
James Edwards
Todd Jones
Christopher Tegley
Lin Zhi
III Horace FLETCHER
Original Assignee
Ligand Pharmaceuticals, Inc.
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,633 external-priority patent/US6509334B1/en
Application filed by Ligand Pharmaceuticals, Inc., Wyeth filed Critical Ligand Pharmaceuticals, Inc.
Publication of BG106079A publication Critical patent/BG106079A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides compounds of formula wherein R1 and R2 may be single substituents or fused to form spirocycle or heterospirocycle ring; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, CORC; RC is H, C1 to C3 alkyl, substituted C 1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy, substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2 or 3 heteroatoms from the group including O, S, SO2 or NR6 and containing one or two independent substituents from the group including H, halogen, CN, NO2, amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C33 aminoalkyl, CORF, or NRGCORF; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions using the compounds as antagonists of the progesterone receptor. 22 claims
BG106079A 1999-05-04 2001-11-02 Cyclocarbamate derivatives as progesterone receptor modulators BG106079A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18301299P 1999-05-04 1999-05-04
US09/552,633 US6509334B1 (en) 1999-05-04 2000-04-19 Cyclocarbamate derivatives as progesterone receptor modulators
PCT/US2000/011822 WO2000066571A1 (en) 1999-05-04 2000-05-01 Cyclocarbamate derivatives as progesterone receptor modulators

Publications (1)

Publication Number Publication Date
BG106079A true BG106079A (en) 2002-05-31

Family

ID=26878647

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106079A BG106079A (en) 1999-05-04 2001-11-02 Cyclocarbamate derivatives as progesterone receptor modulators

Country Status (19)

Country Link
EP (1) EP1173426A1 (en)
JP (1) JP2002543193A (en)
KR (1) KR20010114250A (en)
CN (1) CN1145618C (en)
AU (1) AU766428B2 (en)
BG (1) BG106079A (en)
BR (1) BR0010213A (en)
CA (1) CA2371726A1 (en)
CZ (1) CZ20013951A3 (en)
EA (1) EA004512B1 (en)
HU (1) HUP0201609A3 (en)
IL (1) IL146280A0 (en)
MX (1) MXPA01011286A (en)
NO (1) NO321361B1 (en)
NZ (1) NZ515355A (en)
PL (1) PL351127A1 (en)
SG (1) SG114650A1 (en)
SK (1) SK15912001A3 (en)
TR (1) TR200103286T2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005238520B2 (en) * 2004-04-27 2011-09-08 Wyeth Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
EP1844768A1 (en) * 2005-01-19 2007-10-17 Dainippon Sumitomo Pharma Co., Ltd. Aromatic sulfone compound as aldosterone receptor modulator
ES2549084T3 (en) 2007-10-05 2015-10-22 Msd K.K. Benzoxazinone derivatives
CN111925353B (en) * 2020-08-31 2022-04-08 苏州大学附属第二医院 Preparation method of 2-thiophenecarbonitrile

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510235A1 (en) * 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same
WO1995020389A1 (en) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
DK0800519T3 (en) * 1994-12-22 2004-03-01 Ligand Pharm Inc Steroid receptor modulator compounds and methods
ATE248826T1 (en) * 1996-10-02 2003-09-15 Bristol Myers Squibb Pharma Co 4,4-DISUBSTITUTED 1,4-DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE APPLICABLE AS HIV REVERS TRANSCRIPTASE INHIBITORS, INTERMEDIATE PRODUCTS AND METHODS FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
IL146280A0 (en) 2002-07-25
EP1173426A1 (en) 2002-01-23
JP2002543193A (en) 2002-12-17
CZ20013951A3 (en) 2002-05-15
BR0010213A (en) 2002-02-19
NO20015378D0 (en) 2001-11-02
CN1349517A (en) 2002-05-15
SK15912001A3 (en) 2002-06-04
EA200101176A1 (en) 2002-04-25
HUP0201609A3 (en) 2002-12-28
HUP0201609A2 (en) 2002-08-28
SG114650A1 (en) 2005-09-28
MXPA01011286A (en) 2003-07-14
PL351127A1 (en) 2003-03-24
NO20015378L (en) 2002-01-03
CN1145618C (en) 2004-04-14
AU4688600A (en) 2000-11-17
AU766428B2 (en) 2003-10-16
EA004512B1 (en) 2004-04-29
CA2371726A1 (en) 2000-11-09
NO321361B1 (en) 2006-05-02
NZ515355A (en) 2004-02-27
KR20010114250A (en) 2001-12-31
TR200103286T2 (en) 2002-07-22

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