DE602007005811D1 - 6-substituierte isochinolinderivate als rock-1-inhibitoren - Google Patents

6-substituierte isochinolinderivate als rock-1-inhibitoren

Info

Publication number
DE602007005811D1
DE602007005811D1 DE602007005811T DE602007005811T DE602007005811D1 DE 602007005811 D1 DE602007005811 D1 DE 602007005811D1 DE 602007005811 T DE602007005811 T DE 602007005811T DE 602007005811 T DE602007005811 T DE 602007005811T DE 602007005811 D1 DE602007005811 D1 DE 602007005811D1
Authority
DE
Germany
Prior art keywords
alkyl
halogen
substituted
rock
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007005811T
Other languages
English (en)
Inventor
Peter Christopher Ray
Steven Laats
John Richard Morphy
Brad Sherborne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of DE602007005811D1 publication Critical patent/DE602007005811D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE602007005811T 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1-inhibitoren Active DE602007005811D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119142 2006-08-18
PCT/EP2007/058593 WO2008020081A1 (en) 2006-08-18 2007-08-17 6-substituted isoquinoline derivatives as rock-1 inhibitors

Publications (1)

Publication Number Publication Date
DE602007005811D1 true DE602007005811D1 (de) 2010-05-20

Family

ID=37062542

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007005811T Active DE602007005811D1 (de) 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1-inhibitoren

Country Status (10)

Country Link
US (1) US7893088B2 (de)
EP (1) EP2054389B1 (de)
JP (1) JP5341758B2 (de)
CN (1) CN101522633B (de)
AT (1) ATE463483T1 (de)
CA (1) CA2660489A1 (de)
DE (1) DE602007005811D1 (de)
ES (1) ES2341809T3 (de)
MX (1) MX2009001804A (de)
WO (1) WO2008020081A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2611295C (en) * 2005-06-28 2014-04-22 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
CA2615577C (en) 2005-07-26 2014-09-09 Sanofi-Aventis Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
EP1912949B1 (de) 2005-07-26 2011-08-24 Sanofi Cyclohexylaminisochinolonderivate als rho-kinase-inhibitor
ES2364511T3 (es) * 2006-12-27 2011-09-05 Sanofi Derivados de isoquinolona e isoquinolinona sustituidos con cicloalquilamina.
WO2008077551A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinolone derivatives
AU2007338406B2 (en) 2006-12-27 2012-08-09 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of Rho-kinase
MX2009006517A (es) 2006-12-27 2009-06-26 Sanofi Aventis Nuevos derivados de isoquinolina e isoquinolinona sustituidos.
ES2363105T3 (es) * 2006-12-27 2011-07-20 Sanofi-Aventis Isoquinolinas sustituidas y su uso como inhibidores de rho-quinasa.
CN101578266B (zh) * 2006-12-27 2013-10-30 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹啉和异喹啉酮衍生物
WO2008077554A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
SI2303845T1 (sl) * 2008-06-24 2013-12-31 Sanofi Bi- in policiklični substituirani izokinolin in izokinolinski derivati kot inhibitorji rho-kinaze
NZ590070A (en) * 2008-06-24 2012-02-24 Sanofi Aventis Substituted isoquinolines and isoquinolinones as rho kinase inhibitors
BRPI0914735A2 (pt) * 2008-06-24 2019-09-24 Sanofi Aventis isoquinolinas e isoquinolinonas 6-substituídas
US8299096B2 (en) * 2008-06-26 2012-10-30 Inspire Pharmaceuticals, Inc. Method for treating pulmonary diseases using rho kinase inhibitor compounds
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20220002266A1 (en) * 2018-11-09 2022-01-06 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and use thereof
WO2021155195A1 (en) * 2020-01-29 2021-08-05 Georgetown University Compositions and methods for treating neurodegenerative, neurodevelopmental, myodegenerative, and lysosomal storage disorders
CN111440150B (zh) * 2020-05-12 2021-04-06 中国药科大学 一种一氧化氮供体型法舒地尔衍生物及其制备方法和用途
WO2023196291A1 (en) * 2022-04-05 2023-10-12 University Of Washington Method to improve cell viability of cardiomyocytes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100833A1 (fr) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Inhibiteurs de rho kinase
JPWO2004009555A1 (ja) 2002-07-22 2005-11-17 旭化成ファーマ株式会社 ５−置換イソキノリン誘導体
AU2003264427A1 (en) 2002-09-12 2004-04-30 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
EP1912949B1 (de) 2005-07-26 2011-08-24 Sanofi Cyclohexylaminisochinolonderivate als rho-kinase-inhibitor
US7618985B2 (en) 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives

Also Published As

Publication number Publication date
US7893088B2 (en) 2011-02-22
JP5341758B2 (ja) 2013-11-13
MX2009001804A (es) 2009-02-26
CN101522633B (zh) 2012-05-09
CN101522633A (zh) 2009-09-02
JP2010501480A (ja) 2010-01-21
ES2341809T3 (es) 2010-06-28
WO2008020081A1 (en) 2008-02-21
US20080045566A1 (en) 2008-02-21
EP2054389B1 (de) 2010-04-07
EP2054389A1 (de) 2009-05-06
CA2660489A1 (en) 2008-02-21
ATE463483T1 (de) 2010-04-15

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