RS51190B - Aminoacilni derivati kao prolekovi i lekovi za lečenje tromboembolijskih bolesti - Google Patents

Aminoacilni derivati kao prolekovi i lekovi za lečenje tromboembolijskih bolesti

Info

Publication number
RS51190B
RS51190B RSP-2009/0408A RSP20090408A RS51190B RS 51190 B RS51190 B RS 51190B RS P20090408 A RSP20090408 A RS P20090408A RS 51190 B RS51190 B RS 51190B
Authority
RS
Serbia
Prior art keywords
denotes
group
thromboembolitic
medicaments
disorders
Prior art date
Application number
RSP-2009/0408A
Other languages
English (en)
Inventor
Hans-Georg Lerchen
Ursula Krenz
Karl-Heinz Schlemmer
Elisabeth Perzborn
Joerg Keldenich
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of RS51190B publication Critical patent/RS51190B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Jedinjenje formule (I)u kojojR1 označava vodonik ili (C1-C4)-alkil, koji može biti supstituisan sa hidroksi (C1-C4)-alkoksi,R2 označava vodonik ili (C1-C4)-alkiliL označava (C1-C4)-alkandiil-grupu, u kojoj CH2-grupa može biti supstituisana sa O atomom, ili označava grupu formuleiliu kojoj* označava mesto vezivanja za N-atom,R3 označava bočnu grupu prirodne α-aminokiseline ili njene homologe ili izomereiliR3 je povezano sa R1 i oba zajedno obrazuju (CH2)3 ili (CH2)4 grupu, R4 označava vodonik ili metil, R5 označava (C1-C4)-alkil,iR6 označava vodonik ili (C1-C4)-alkil,kao i njegove soli, solvati i solvati njegovih soli.Prijava sadrži još 10 patentnih zahteva.
RSP-2009/0408A 2006-02-16 2007-02-06 Aminoacilni derivati kao prolekovi i lekovi za lečenje tromboembolijskih bolesti RS51190B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006007146A DE102006007146A1 (de) 2006-02-16 2006-02-16 Aminoacyl-Prodrugs
PCT/EP2007/001135 WO2007093328A1 (de) 2006-02-16 2007-02-06 Aminoacyl-prodrug derivate und arzneimittel zur behandlung von thromboembolischen erkrankungen

Publications (1)

Publication Number Publication Date
RS51190B true RS51190B (sr) 2010-10-31

Family

ID=38179935

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0408A RS51190B (sr) 2006-02-16 2007-02-06 Aminoacilni derivati kao prolekovi i lekovi za lečenje tromboembolijskih bolesti

Country Status (23)

Country Link
US (2) US8101601B2 (sr)
EP (1) EP1987026B1 (sr)
JP (1) JP5225864B2 (sr)
KR (1) KR20080094696A (sr)
CN (1) CN101384585B (sr)
AT (1) ATE440839T1 (sr)
AU (1) AU2007214766B2 (sr)
BR (1) BRPI0708064A2 (sr)
CA (1) CA2642376C (sr)
CY (1) CY1109375T1 (sr)
DE (2) DE102006007146A1 (sr)
DK (1) DK1987026T3 (sr)
ES (1) ES2330689T3 (sr)
HK (1) HK1130252A1 (sr)
HR (1) HRP20090629T1 (sr)
IL (1) IL192987A0 (sr)
PL (1) PL1987026T3 (sr)
PT (1) PT1987026E (sr)
RS (1) RS51190B (sr)
RU (1) RU2435768C2 (sr)
SI (1) SI1987026T1 (sr)
WO (1) WO2007093328A1 (sr)
ZA (1) ZA200806891B (sr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007032347A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102007032345A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
US7816355B1 (en) 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
CN101875655B (zh) * 2009-04-28 2012-05-09 天津药物研究院 氨基苯甲酸衍生物及其制备方法和用途
US8971019B2 (en) 2012-03-16 2015-03-03 Avx Corporation Wet capacitor cathode containing an alkyl-substituted poly(3,4-ethylenedioxythiophene)
CN102746287B (zh) * 2012-06-21 2014-05-28 成都苑东药业有限公司 一种恶唑烷酮化合物及其制备方法
WO2014102820A2 (en) 2012-12-26 2014-07-03 Wanbury Ltd. Rivaroxaban intermediate and preparation thereof
WO2014102822A2 (en) * 2012-12-26 2014-07-03 Wanbury Ltd. Aldehyde derivative of substitute oxazolidinones
CN114384185A (zh) * 2022-01-20 2022-04-22 北京航空航天大学 用于检测γ-氨基丁酸含量的试剂在制备诊断静脉流出障碍性疾病的试剂盒中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377278C (en) * 1999-06-25 2010-03-23 Vertex Pharmaceuticals Incorporated Prodrugs of carbamate inhibitors of impdh
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
EP1451164A2 (en) * 2001-07-12 2004-09-01 PHARMACIA & UPJOHN COMPANY Amide derivatives having improved solubility
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004002044A1 (de) 2004-01-15 2005-08-04 Bayer Healthcare Ag Herstellverfahren
DE102004062475A1 (de) 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
DE102005047558A1 (de) 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II

Also Published As

Publication number Publication date
WO2007093328A1 (de) 2007-08-23
US20120088761A1 (en) 2012-04-12
US8101601B2 (en) 2012-01-24
EP1987026A1 (de) 2008-11-05
HK1130252A1 (en) 2009-12-24
ATE440839T1 (de) 2009-09-15
CY1109375T1 (el) 2014-07-02
CA2642376A1 (en) 2007-08-23
SI1987026T1 (sl) 2010-01-29
JP5225864B2 (ja) 2013-07-03
ZA200806891B (en) 2010-02-24
CA2642376C (en) 2014-08-12
KR20080094696A (ko) 2008-10-23
PT1987026E (pt) 2009-10-30
DE102006007146A1 (de) 2007-08-23
ES2330689T3 (es) 2009-12-14
BRPI0708064A2 (pt) 2011-05-17
US20110034453A1 (en) 2011-02-10
US8334284B2 (en) 2012-12-18
PL1987026T3 (pl) 2010-03-31
CN101384585B (zh) 2012-09-26
RU2435768C2 (ru) 2011-12-10
EP1987026B1 (de) 2009-08-26
CN101384585A (zh) 2009-03-11
HRP20090629T1 (hr) 2010-01-31
DK1987026T3 (da) 2009-11-02
AU2007214766B2 (en) 2013-05-02
AU2007214766A1 (en) 2007-08-23
DE502007001402D1 (de) 2009-10-08
IL192987A0 (en) 2009-02-11
RU2008136769A (ru) 2010-03-27
JP2009526788A (ja) 2009-07-23

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