MX2012000577A - Compuestos de amino spiro apropiados para el tratamiento entre otras cosas de trastornos de sueño y adiccion a los farmacos. - Google Patents

Compuestos de amino spiro apropiados para el tratamiento entre otras cosas de trastornos de sueño y adiccion a los farmacos.

Info

Publication number
MX2012000577A
MX2012000577A MX2012000577A MX2012000577A MX2012000577A MX 2012000577 A MX2012000577 A MX 2012000577A MX 2012000577 A MX2012000577 A MX 2012000577A MX 2012000577 A MX2012000577 A MX 2012000577A MX 2012000577 A MX2012000577 A MX 2012000577A
Authority
MX
Mexico
Prior art keywords
treatment
inter alia
sleep disorders
compounds suitable
amino compounds
Prior art date
Application number
MX2012000577A
Other languages
English (en)
Inventor
Luigi Piero Stasi
Lucio Rovati
Original Assignee
Rottapharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Spa filed Critical Rottapharm Spa
Publication of MX2012000577A publication Critical patent/MX2012000577A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se relaciona con un compuesto spiro-amino de la Fórmula (VI) en donde m es 1 ó 2 ó 3, n es 1 ó 2, R se selecciona de un anillo aromático de 5 ó 6 miembros y un anillo heteroaromático de 5 ó 6 miembros que comprende de 1 a 3 heteroátomos seleccionados de S, O y N, tal anillo es substituido con uno o dos sustituyentes seleccionados del grupo que consiste de alquilo(C1-C3), halógeno, cicloalquiloxi(C3-C5), alquilcarbonilo(C1-C3), fenilo opcionalmente substituido con uno o más átomos de halógeno, un heterociclo de 5 ó 6 miembros que comprende por lo menos un átomo de nitrógeno; P es un sustituyente Q o COQ, en donde Q es seleccionado del grupo que consiste de fenilo, piridilo, pirimidilo, quinolilo, isoquinolilo, quinoxalilo, benzofuranilo, imidazotriazolilo, tal Q es opcionalmente substituido con uno o más sustituyentes seleccionados del grupo que consiste de alquilo(C1-C3), halógeno, trifluorometilo, carbamido, metilcarbamido, carboxi; metilcarboxi o una sal farmacéuticamente aceptable del mismo.
MX2012000577A 2009-07-15 2010-07-15 Compuestos de amino spiro apropiados para el tratamiento entre otras cosas de trastornos de sueño y adiccion a los farmacos. MX2012000577A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09425285A EP2275421A1 (en) 2009-07-15 2009-07-15 Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
PCT/EP2010/060206 WO2011006960A1 (en) 2009-07-15 2010-07-15 Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction

Publications (1)

Publication Number Publication Date
MX2012000577A true MX2012000577A (es) 2012-05-08

Family

ID=41820711

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000577A MX2012000577A (es) 2009-07-15 2010-07-15 Compuestos de amino spiro apropiados para el tratamiento entre otras cosas de trastornos de sueño y adiccion a los farmacos.

Country Status (12)

Country Link
US (1) US8859608B2 (es)
EP (2) EP2275421A1 (es)
JP (1) JP5814917B2 (es)
KR (1) KR101736424B1 (es)
CN (1) CN102471314B (es)
AU (1) AU2010272548B2 (es)
BR (1) BR112012001031A8 (es)
CA (1) CA2768329C (es)
ES (1) ES2537658T3 (es)
MX (1) MX2012000577A (es)
RU (1) RU2562609C2 (es)
WO (1) WO2011006960A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484674A1 (en) 2011-02-02 2012-08-08 Rottapharm S.P.A. Spiro aminic compounds with NK1 antagonist activity
BR112014000087B1 (pt) 2011-07-04 2021-08-17 Rottapharm Biotech S.R.L. Derivados de amina cíclica como antagonistas do receptor ep4
ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
EP2811997B1 (en) 2012-02-07 2018-04-11 Eolas Therapeutics Inc. Substituted prolines/piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ITMI20120322A1 (it) 2012-03-01 2013-09-02 Rottapharm Spa Composti di 4,4-difluoro piperidina
ITMI20120424A1 (it) 2012-03-19 2013-09-20 Rottapharm Spa Composti chimici
HUE040555T2 (hu) * 2013-12-04 2019-03-28 Idorsia Pharmaceuticals Ltd Benzimidazol prolin származékok alkalmazása
JP2017024990A (ja) * 2013-12-13 2017-02-02 大正製薬株式会社 オキサゾリジン及びオキサジナン誘導体
US10221170B2 (en) 2014-08-13 2019-03-05 Eolas Therapeutics, Inc. Difluoropyrrolidines as orexin receptor modulators
CN104610129B (zh) * 2015-01-08 2017-07-18 爱斯特（成都）生物制药有限公司 一种手性2‑取代基‑4‑哌啶酮‑1‑羧酸叔丁酯的合成方法
HUE059280T2 (hu) 2016-02-12 2022-11-28 Astrazeneca Ab Halogén-szubsztituált piperidinek mint orexin receptor modulátorok
GB2558975B (en) * 2017-09-01 2019-01-23 Chronos Therapeutics Ltd Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
WO2019043407A1 (en) * 2017-09-01 2019-03-07 Chronos Therapeutics Limited DERIVATIVES OF 2-AZABICYCLO [3.1.1] HEPTANE AND 2-AZABICYCLO [3.2.1] OCTANE SUBSTITUTED AS OREXIN RECEPTOR ANTAGONISTS
CN116583502A (zh) * 2020-09-03 2023-08-11 欧瑞夏治疗有限公司 二环-杂环衍生物及其作为食欲素-2受体激动剂的用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282927A (en) 1964-05-21 1966-11-01 Bristol Myers Co 5-phenyl-4-thiazolylpenicillins
RO115804B1 (ro) * 1992-12-11 2000-06-30 Merck & Co Inc Derivati de spiropiperidine, procedee de preparare si compozitii farmaceutice ale acestora
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
IT1286141B1 (it) 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
EP1385845B1 (en) 2001-05-05 2008-01-09 Smithkline Beecham Plc N-aroyl cyclic amines
GB0130393D0 (en) 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
US20060040937A1 (en) 2002-09-18 2006-02-23 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
AU2006282955A1 (en) * 2005-08-26 2007-03-01 Merck & Co., Inc. Diazaspirodecane orexin receptor antagonists
KR20090077051A (ko) * 2006-09-29 2009-07-14 액테리온 파마슈티칼 리미티드 3-아자-비시클로[3.1.0]헥산 유도체
US20080287479A1 (en) 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
TW200833328A (en) * 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
EP2155739B1 (en) * 2007-05-14 2010-10-06 Actelion Pharmaceuticals Ltd. 2-cyclopropyl-thiazole derivatives
ES2379744T3 (es) 2007-05-23 2012-05-03 Merck Sharp & Dohme Corp. Antagonistas de piridil-piperidina de los receptores de orexinas
EP2185512B1 (en) 2007-07-27 2010-12-29 Actelion Pharmaceuticals Ltd. Trans-3-aza-bicyclo[3.1.0]hexane derivatives
JP2010540429A (ja) 2007-09-24 2010-12-24 アクテリオン ファーマシューティカルズ リミテッド オレキシン受容体拮抗薬としてのピロリジン類及びピペリジン類
JP2011512400A (ja) * 2008-02-21 2011-04-21 アクテリオン ファーマシューティカルズ リミテッド ２−アザ−ビシクロ［２．２．１］ヘプタン誘導体

Also Published As

Publication number Publication date
AU2010272548A1 (en) 2012-02-23
CA2768329C (en) 2017-03-07
BR112012001031A8 (pt) 2017-09-19
JP5814917B2 (ja) 2015-11-17
US20120115882A1 (en) 2012-05-10
EP2275421A1 (en) 2011-01-19
EP2454252B1 (en) 2015-03-04
AU2010272548B2 (en) 2013-08-22
EP2454252A1 (en) 2012-05-23
ES2537658T3 (es) 2015-06-10
WO2011006960A1 (en) 2011-01-20
RU2562609C2 (ru) 2015-09-10
CN102471314A (zh) 2012-05-23
CA2768329A1 (en) 2011-01-20
RU2012105284A (ru) 2013-08-20
KR20120038487A (ko) 2012-04-23
BR112012001031A2 (pt) 2016-11-22
US8859608B2 (en) 2014-10-14
KR101736424B1 (ko) 2017-05-29
CN102471314B (zh) 2015-05-13
JP2012532916A (ja) 2012-12-20

Similar Documents

Publication Publication Date Title
MX2012000577A (es) Compuestos de amino spiro apropiados para el tratamiento entre otras cosas de trastornos de sueño y adiccion a los farmacos.
MY192109A (en) Aminopyrimidinyl compounds as jak inhibitors
JO3114B1 (ar) مركبات بيريدازينون
EA201290260A1 (ru) Бензимидазол-имидазольные производные
EA200800815A1 (ru) 2-анилин-4-арилзамещенные тиазольные производные
WO2003024967A3 (en) Indolizines as kinase protein inhibitors
IN2014DN03063A (es)
JP2014525420A5 (es)
MY169179A (en) Novel piperidine compound or salt thereof
SI2751083T1 (en) Quinolone compound
JO2791B1 (en) Acid secretion inhibitor
NZ532494A (en) Dibenzylamine compound and medicinal use thereof
MX2020011652A (es) Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn.
RS54708B1 (en) ARYLETINYL DERIVATIVES
ATE463483T1 (de) 6-substituierte isochinolinderivate als rock-1- inhibitoren
MX2014015501A (es) Carboxamidas heterociclicas fungicidas.
EP2597088A4 (en) P2X4 Receptor Antagonists
JP2013509392A5 (es)
MX2009010790A (es) Derivados de heteroarilo biciclico fusionados.
MX2010008361A (es) Derivados de arilamida oxazepinopirimidona sustituidos.
AR049276A1 (es) Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen
MX2010008362A (es) Derivados de heteroarilamida diazepinopirimidona sustituidos.
MX2016008536A (es) Derivados de fluoro-naftilo.
TW200719894A (en) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives
AR063577A1 (es) Derivados 8- piperidinil - pirimido [1 2 a] pirimidin -6-ona y 8- piperidinil-2- pirimidinil- pirimido [1,2-a] pirimidin -6- ona sustituidos

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ROTTAPHARM BIOTECH S.R.L.

FG Grant or registration