BR0109457A - Composto, composição farmacêutica,método de preparação de composições farmacêuticas, processo para prepapação de compostos, e, métodos de tratamento de distúrbios psiquiátricos, de distúrbios gastrointestinais e de distúrbios cardiovasculares - Google Patents

Composto, composição farmacêutica,método de preparação de composições farmacêuticas, processo para prepapação de compostos, e, métodos de tratamento de distúrbios psiquiátricos, de distúrbios gastrointestinais e de distúrbios cardiovasculares

Info

Publication number
BR0109457A
BR0109457A BR0109457-2A BR0109457A BR0109457A BR 0109457 A BR0109457 A BR 0109457A BR 0109457 A BR0109457 A BR 0109457A BR 0109457 A BR0109457 A BR 0109457A
Authority
BR
Brazil
Prior art keywords
preparing
compound
methods
pharmaceutical composition
pharmaceutical compositions
Prior art date
Application number
BR0109457-2A
Other languages
English (en)
Inventor
Josephus H M Lange
Cornelis G Kruse
Jacobus Tipker
Martinus T M Tulp
Bernardus J Van Vliet
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of BR0109457A publication Critical patent/BR0109457A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO DE PREPARAçãO DE COMPOSIçõES FARMACêUTICAS, PROCESSO PARA PREPARAçãO DE COMPOSTOS, E, MéTODOS DE TRATAMENTO DE DISTúRBIOS PSIQUIáTRICOS, DE DISTúRBIOS GASTROINTESTINAIS E DE DISTúRBIOS CARDIOVASCULARES". A presente invenção refere-se a um grupo de novos derivados de 4,5-diidro-1H-pirazol, que são potentes antagonistas de receptor CB~ 1~ de Cannabis. Os compostos possuem fórmula geral (I) em que R e R~ 1~ são iguais ou diferentes e representam fenila, tienila ou piridila, grupos esses que podem ser substituidos com 1,2 ou 3 substituintes Y, ou R e/ou R~ 1~ representam naftila, R~ 2~ representa hidrogênio, hidróxi, C~ 1- 3~alcóxi, acetilóxi ou propionilóxi, Aa representa um dos grupos (i), (ii), (iii), (iv) ou (v), Bb representa sulfonila ou carbonila, R~ 3~ representa benzila, fenila, tienila ou piridila que podem ser substituídas com 1, 2 ou 3 substituintes Y ou R~ 3~ representa C~ 1-8~ alquila ramificada ou não ramificada ou C~ 3-8~ cicloalquila ou R~ 3~ representa naftila.
BR0109457-2A 2000-03-23 2001-03-22 Composto, composição farmacêutica,método de preparação de composições farmacêuticas, processo para prepapação de compostos, e, métodos de tratamento de distúrbios psiquiátricos, de distúrbios gastrointestinais e de distúrbios cardiovasculares BR0109457A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00201032 2000-03-23
NL1014728 2000-03-23
PCT/EP2001/003247 WO2001070700A1 (en) 2000-03-23 2001-03-22 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity

Publications (1)

Publication Number Publication Date
BR0109457A true BR0109457A (pt) 2003-06-03

Family

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Family Applications (1)

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BR0109457-2A BR0109457A (pt) 2000-03-23 2001-03-22 Composto, composição farmacêutica,método de preparação de composições farmacêuticas, processo para prepapação de compostos, e, métodos de tratamento de distúrbios psiquiátricos, de distúrbios gastrointestinais e de distúrbios cardiovasculares

Country Status (26)

Country Link
US (1) US6476060B2 (pt)
EP (1) EP1268435B1 (pt)
JP (1) JP2004500401A (pt)
KR (1) KR100800277B1 (pt)
CN (1) CN1205188C (pt)
AT (1) ATE346047T1 (pt)
AU (2) AU4250101A (pt)
BR (1) BR0109457A (pt)
CA (1) CA2401832C (pt)
CY (1) CY1105967T1 (pt)
DE (1) DE60124685T2 (pt)
DK (1) DK1268435T3 (pt)
DZ (1) DZ3335A1 (pt)
ES (1) ES2272449T3 (pt)
HK (1) HK1052349B (pt)
HU (1) HUP0204519A3 (pt)
IL (2) IL151452A0 (pt)
MX (1) MXPA02009258A (pt)
NO (1) NO324173B1 (pt)
PL (1) PL208098B1 (pt)
PT (1) PT1268435E (pt)
RU (1) RU2245878C2 (pt)
SI (1) SI1268435T1 (pt)
SK (1) SK287074B6 (pt)
UA (1) UA74367C2 (pt)
WO (1) WO2001070700A1 (pt)

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