ES2030627A6 - Procedimiento para la obtencion de compuestos benzopiranicos. - Google Patents
Procedimiento para la obtencion de compuestos benzopiranicos.Info
- Publication number
- ES2030627A6 ES2030627A6 ES9003264A ES9003264A ES2030627A6 ES 2030627 A6 ES2030627 A6 ES 2030627A6 ES 9003264 A ES9003264 A ES 9003264A ES 9003264 A ES9003264 A ES 9003264A ES 2030627 A6 ES2030627 A6 ES 2030627A6
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- alkoxycarbonyl
- optionally substituted
- pharmacological activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS BENZOPIRANICOS DE FORMULA GENERAL I UTILES COMO REGULADORES DE LA CONTRACCION DE LA MUSCULATURA LISA EN LOS SISTEMAS CARDIOVACULAR, BRONCOPULMONAR Y DIGESTIVO: EN DONDE RBS1 REPRESENTA UN GRUPO CIANO O NITRO; RBS2 REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO; RBS3 REPRESENTA UN ATOMO DE NITROGENO O UN GRUPO CSI1-4 ALQUILO Y RBS4 ES CSI1-4 ALQUILO O RBS3 Y RBS4 JUNTOS SON POLIMETILENO; RBS5 ES OH Y RBS6 HIDROGENO, O BIEN LOS DOS JUNTOS FORMAN UN DOBLE ENLACE; RBS7 ES HIDROGENO O CSI1-6 ALQUILO; RBS8 ES UN GRUPO CICLOPENTILO, CICLOHEXILO, 1-PIPERAZINILO, 1-PIRROLIDINILO, 2-PIRROLIDINILO, 1-PIPERIDINILO, 2-PIPERIDINILO, 3-PIPERIDINILO, 4-PIPERIDINILO O 1-MORFOLINILO, OPCIONALMENTE SUSTITUIDOS POR UNO O DOS GRUPOS RBS9; RBS9 ES UN GRUPO HIDROXILO, OXO, CSI1-6-ALCOXICARBONILO, CSI1-6 ALQUILAMINOCARBONILO, CSI1-6 ALQUILCARBONILO, CSI1-6 ALQUILOXICARBONILMETILO, FENILOXICARBONILO O FENILMETILOXICARBONILO Y X ES UN ATOMO DE OXIGENO O AZUFRE, CARACTERIZADO PORQUE SE HACE REACCIONAR EL CORRESPONDIENTE 3-HIDROXI-4-AMINOBENZOPIRANO CON UN ACIDO CARBOXILICO EN PRESENCIA DE DICICLOHEXILCARBODIIMIDA EN EL SENO DE UN DISOLVENTE POLAR COMO DIMETILFORMAMIDA.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003264A ES2030627A6 (es) | 1990-11-28 | 1990-11-28 | Procedimiento para la obtencion de compuestos benzopiranicos. |
EP91120417A EP0488301A1 (en) | 1990-11-28 | 1991-11-28 | New benzopyran compounds with pharmacological activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003264A ES2030627A6 (es) | 1990-11-28 | 1990-11-28 | Procedimiento para la obtencion de compuestos benzopiranicos. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2030627A6 true ES2030627A6 (es) | 1992-11-01 |
Family
ID=8270142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9003264A Expired - Lifetime ES2030627A6 (es) | 1990-11-28 | 1990-11-28 | Procedimiento para la obtencion de compuestos benzopiranicos. |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0488301A1 (es) |
ES (1) | ES2030627A6 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994012493A1 (en) * | 1992-11-25 | 1994-06-09 | Sandoz, Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-benzopyr ans, their use as pharmaceuticals |
US5574049A (en) * | 1994-07-22 | 1996-11-12 | Sandoz Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans |
GB9510477D0 (en) * | 1995-05-24 | 1995-07-19 | Sandoz Ltd | Organic compounds |
GB9822024D0 (en) * | 1998-10-09 | 1998-12-02 | Novartis Ag | Organic compounds |
TWI346112B (en) * | 2004-02-25 | 2011-08-01 | Nissan Chemical Ind Ltd | Benzopyran compound |
EP1836183A2 (en) | 2004-12-13 | 2007-09-26 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
CA2620846A1 (en) * | 2005-09-01 | 2007-03-08 | Janssen Pharmaceutica N.V. | Benzopyran and pyranopyridine derivatives as potassium channel openers |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0095316B1 (en) * | 1982-05-21 | 1986-12-03 | Beecham Group Plc | Pharmaceutically active aminobenzopyrans |
DE3479726D1 (de) * | 1983-05-18 | 1989-10-19 | Beecham Group Plc | Benzopyran derivatives. |
-
1990
- 1990-11-28 ES ES9003264A patent/ES2030627A6/es not_active Expired - Lifetime
-
1991
- 1991-11-28 EP EP91120417A patent/EP0488301A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP0488301A1 (en) | 1992-06-03 |
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