DE3864636D1 - Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen. - Google Patents

Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.

Info

Publication number
DE3864636D1
DE3864636D1 DE8888114257T DE3864636T DE3864636D1 DE 3864636 D1 DE3864636 D1 DE 3864636D1 DE 8888114257 T DE8888114257 T DE 8888114257T DE 3864636 T DE3864636 T DE 3864636T DE 3864636 D1 DE3864636 D1 DE 3864636D1
Authority
DE
Germany
Prior art keywords
lower alkyl
halogen
amino
activation
gastromotoric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888114257T
Other languages
English (en)
Inventor
Yasuo Itoh
Hideo Kato
Eiichi Koshinaka
Nobuo Ogawa
Hiroyuki Nishino
Jun Sakaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
HOKURIKU PHARMACEUTICAL CO Ltd KATSUYAMA FUKUI JP
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62221211A external-priority patent/JPS6466153A/ja
Priority claimed from JP62236250A external-priority patent/JPS6479144A/ja
Priority claimed from JP62242765A external-priority patent/JPS6485960A/ja
Priority claimed from JP62249749A external-priority patent/JPH0193568A/ja
Application filed by HOKURIKU PHARMACEUTICAL CO Ltd KATSUYAMA FUKUI JP, Hokuriku Pharmaceutical Co Ltd filed Critical HOKURIKU PHARMACEUTICAL CO Ltd KATSUYAMA FUKUI JP
Application granted granted Critical
Publication of DE3864636D1 publication Critical patent/DE3864636D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Hybrid Electric Vehicles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
DE8888114257T 1987-09-05 1988-09-01 Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen. Expired - Lifetime DE3864636D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP62221211A JPS6466153A (en) 1987-09-05 1987-09-05 Amide compound and digestive tract motion-activator containing said compound as active ingredient
JP62236250A JPS6479144A (en) 1987-09-22 1987-09-22 Amide compound and agent for promoting motion of digestive tract containing said compound
JP62242765A JPS6485960A (en) 1987-09-29 1987-09-29 Amide compound and reactivator for motion of digestive tube comprising said compound as active ingredient
JP62249749A JPH0193568A (ja) 1987-10-05 1987-10-05 アミド化合物、及びそれを有効成分とする消化管運動賦活剤

Publications (1)

Publication Number Publication Date
DE3864636D1 true DE3864636D1 (de) 1991-10-10

Family

ID=27476995

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888114257T Expired - Lifetime DE3864636D1 (de) 1987-09-05 1988-09-01 Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.

Country Status (15)

Country Link
US (1) US4983633A (de)
EP (1) EP0306827B1 (de)
KR (1) KR940000058B1 (de)
AT (1) ATE66913T1 (de)
AU (1) AU606988B2 (de)
BG (1) BG48932A3 (de)
CA (1) CA1335101C (de)
DE (1) DE3864636D1 (de)
DK (1) DK169816B1 (de)
ES (1) ES2037779T3 (de)
FI (1) FI87644C (de)
HU (1) HU198447B (de)
SU (1) SU1627082A3 (de)
UA (1) UA6330A1 (de)
YU (1) YU46706B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970702247A (ko) * 1994-03-30 1997-05-13 고야 마사시 벤조산 화합물 및 이들의 약제로서의 용도(benzoic acid compound and use thereof as medicine)
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
AU1180400A (en) * 1998-11-16 2000-06-05 Hokuriku Seiyaku Co. Ltd Remedies for digestive tract functional disorder
WO2001010823A1 (de) 1999-08-07 2001-02-15 Boehringer Ingelheim Pharma Kg Carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE10235312A1 (de) 2002-08-01 2004-02-12 Basf Ag Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte
CN1305837C (zh) * 2004-06-11 2007-03-21 吉林修正药业新药研发中心 一种改进的伊托必利原料药的制备方法
KR100595117B1 (ko) * 2004-07-28 2006-06-30 일양약품주식회사 이토프라이드·염산염 중간체인4-[2-(디메틸아미노)에톡시]벤질아민의 새로운 제조방법
ITMI20042168A1 (it) * 2004-11-12 2005-02-12 Erregierre Spa Processo di preparazione di itopride cloridrato
KR100663167B1 (ko) * 2005-10-27 2007-01-02 동우신테크 주식회사 염산 이토프리드의 제조방법
WO2007074386A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar A novel process for synthesis of itopride and it’s novel intermediate-n-(4-hydroxybenzyl)-3,4-dimethoxybenzamide
KR100836528B1 (ko) * 2007-07-25 2008-06-10 주식회사 휴온스 이토프리드 염산염의 제조방법
CN101967103A (zh) * 2010-09-28 2011-02-09 浙江金伯士药业有限公司 一种伊托必利中间体的制备新方法
CN103073446B (zh) * 2011-10-26 2014-12-24 珠海保税区丽珠合成制药有限公司 盐酸伊托必利的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1069640B (de) * 1959-11-26 F. Hoffmann-La Roche S. Co. Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von anfemetisch wirksamen Benzylaminderivaten
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
NL130752C (de) * 1964-05-07

Also Published As

Publication number Publication date
DK492288A (da) 1989-03-06
HU198447B (en) 1989-10-30
FI884077A (fi) 1989-03-06
US4983633A (en) 1991-01-08
SU1627082A3 (ru) 1991-02-07
EP0306827B1 (de) 1991-09-04
FI884077A0 (fi) 1988-09-05
DK492288D0 (da) 1988-09-05
FI87644C (fi) 1993-02-10
HUT47531A (en) 1989-03-28
AU606988B2 (en) 1991-02-21
FI87644B (fi) 1992-10-30
BG48932A3 (en) 1991-06-14
ATE66913T1 (de) 1991-09-15
CA1335101C (en) 1995-04-04
EP0306827A1 (de) 1989-03-15
KR940000058B1 (ko) 1994-01-05
DK169816B1 (da) 1995-03-06
YU160088A (en) 1990-06-30
UA6330A1 (uk) 1994-12-29
AU2186288A (en) 1989-03-09
YU46706B (sh) 1994-04-05
ES2037779T3 (es) 1993-07-01
KR890005036A (ko) 1989-05-11

Similar Documents

Publication Publication Date Title
ATE163012T1 (de) N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE3854280D1 (de) Neue cyclische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung.
DE69534029D1 (de) Herstellung von Camptothecinderivaten durch intramolekulare Cyclisierung
DE69133455D1 (de) Zwischenprodukte zur Herstellung von Camptothecin und Analogen
DE3775882D1 (de) Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeuren ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
DE3864636D1 (de) Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.
DK170489D0 (da) Spirocyclisk forbindelse med fem ringe og to heteroatomer, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat og indeholdende en saadan forbindelse
DE69429570T2 (de) Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
ATE9464T1 (de) Neue carbonsaeureamide, ihre herstellung und ihre verwendung als arzneimittel.
DE3769563D1 (de) Neue derivate von 4,5-dihydro-oxazolen, verfahren zu ihrer herstellung und ihre verwendung.
DE3866148D1 (de) Chinolincarbonsaeure-derivate, diese enthaltende zusammensetzung, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von medikamenten.
ATE8389T1 (de) Amino-alkoxy-pyrazole, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
AU590748B2 (en) Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
ATE63544T1 (de) 4-cyanopiperidine-derivate, herstellung und anwendung.
IT1213440B (it) 2-ditioalchil-diidropiridine, un metodo per la loro preparazione e composizioni farmaceutiche chele contengono.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ABBOTT JAPAN CO.,LTD., TOKIO/TOKYO, JP