DK170489D0 - Spirocyclisk forbindelse med fem ringe og to heteroatomer, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat og indeholdende en saadan forbindelse - Google Patents
Spirocyclisk forbindelse med fem ringe og to heteroatomer, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat og indeholdende en saadan forbindelseInfo
- Publication number
- DK170489D0 DK170489D0 DK170489A DK170489A DK170489D0 DK 170489 D0 DK170489 D0 DK 170489D0 DK 170489 A DK170489 A DK 170489A DK 170489 A DK170489 A DK 170489A DK 170489 D0 DK170489 D0 DK 170489D0
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- sulphur
- chem
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010021518 Impaired gastric emptying Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 201000006549 dyspepsia Diseases 0.000 abstract 1
- 206010016766 flatulence Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 208000001288 gastroparesis Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polyesters Or Polycarbonates (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888808433A GB8808433D0 (en) | 1988-04-11 | 1988-04-11 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK170489D0 true DK170489D0 (da) | 1989-04-10 |
| DK170489A DK170489A (da) | 1989-10-12 |
Family
ID=10634939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK170489A DK170489A (da) | 1988-04-11 | 1989-04-10 | Spirocyclisk forbindelse med mindst en ring med fem led og to heteroatomer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4940703A (da) |
| EP (1) | EP0337547B1 (da) |
| JP (1) | JPH01305092A (da) |
| KR (1) | KR900016202A (da) |
| AT (1) | ATE102205T1 (da) |
| AU (1) | AU617785B2 (da) |
| DE (1) | DE68913327T2 (da) |
| DK (1) | DK170489A (da) |
| ES (1) | ES2061933T3 (da) |
| FI (1) | FI891584A (da) |
| GB (1) | GB8808433D0 (da) |
| IE (1) | IE891137L (da) |
| IL (1) | IL89822A0 (da) |
| NO (1) | NO891471L (da) |
| NZ (1) | NZ228583A (da) |
| PT (1) | PT90223B (da) |
| ZA (1) | ZA892587B (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053412A (en) * | 1990-04-10 | 1991-10-01 | Israel Institute For Biological Research | Spiro nitrogen-bridged heterocyclic compounds |
| EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
| IL97726A (en) * | 1990-04-10 | 1994-12-29 | Israel Inst Biolog Res | Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds |
| US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
| JPH05310732A (ja) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−３−カルボン酸誘導体 |
| US6060473A (en) * | 1993-04-01 | 2000-05-09 | Ucb S.A. - Dtb | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands |
| US5817679A (en) * | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
| AU701227B2 (en) * | 1993-09-10 | 1999-01-21 | Cytomed, Inc | Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists |
| US6117889A (en) * | 1994-04-01 | 2000-09-12 | University Of Virginia | 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
| EE03399B1 (et) * | 1994-08-24 | 2001-04-16 | Astra Aktiebolag | Teraapias kasutatavad spiro-asabitsüklilised ühendid ja nende valmistamise protsess |
| IL123536A0 (en) * | 1995-09-18 | 1998-10-30 | Glaxo Group Ltd | 5-HT3 Receptor antagonists for dyskinesia |
| US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| US8309577B2 (en) | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
| US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
| BRPI1007350B8 (pt) * | 2009-01-26 | 2021-05-25 | Israel Institute For Biological Res | compostos espiro heterocíclicos bicíclicos |
| PT2432467T (pt) | 2009-05-20 | 2018-04-04 | Inst Nat Sante Rech Med | Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais |
| ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| CN102686595A (zh) * | 2009-10-28 | 2012-09-19 | 百时美施贵宝公司 | 作为α-7 烟碱乙酰胆碱受体配体的氮杂二环化合物 |
| US8278320B2 (en) | 2009-10-28 | 2012-10-02 | Bristol-Myers Squibb Company | Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| MX2012004560A (es) * | 2009-10-29 | 2012-05-08 | Bristol Myers Squibb Co | Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7. |
| EP2563796B1 (en) | 2010-04-30 | 2015-03-18 | Bristol-Myers Squibb Company | Aza-bicyclic amine n-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs |
| JP5714745B2 (ja) * | 2014-04-28 | 2015-05-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 |
| WO2020180876A1 (en) * | 2019-03-04 | 2020-09-10 | Beth Israel Deaconess Medical Center, Inc. | Orai channel inhibitors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646053A (en) * | 1970-05-18 | 1972-02-29 | American Cyanamid Co | Certain-(2-amino-4-thiazolyl)indoles |
| JPS4917534B1 (da) * | 1970-10-06 | 1974-05-01 | ||
| GB1301254A (da) * | 1971-07-08 | 1972-12-29 | ||
| US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
| AT357555B (de) * | 1975-11-11 | 1980-07-25 | Mundipharma Ag | Verfahren zum herstellen von neuen spiro-(1,3- dioxolan-4,3')chinuclidinen, ihren salzen und isomeren |
| IL48452A (en) * | 1975-11-11 | 1979-07-25 | Purdue Frederick Co | Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them |
| US4342769A (en) * | 1978-10-02 | 1982-08-03 | Schering Corporation | 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants |
| US4203990A (en) * | 1979-04-30 | 1980-05-20 | G. D. Searle & Co. | Anti-diarrheal 2-substituted quinuclidines |
| EP0038298B1 (en) * | 1980-04-10 | 1984-07-25 | Sandoz Ag | Isoxazolyl indolamines |
| US4332804A (en) * | 1981-03-23 | 1982-06-01 | Syntex (U.S.A.) Inc. | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
| DE3218172A1 (de) * | 1982-05-14 | 1983-11-17 | Hoechst Ag, 6230 Frankfurt | Polyalkyldiazaspirodecanderivate, verfahren zu ihrer herstellung und ihre verwendung als stabilisatoren |
| DE3501225A1 (de) * | 1985-01-16 | 1986-07-24 | Sandoz-Patent-GmbH, 7850 Lörrach | Spirodioxolane, ihre herstellung und verwendung |
| DE3504284A1 (de) * | 1985-02-08 | 1986-08-14 | Sandoz-Patent-GmbH, 7850 Lörrach | Spiro-dithiolane, ihre herstellung und verwendung |
| DE3504286A1 (de) * | 1985-02-08 | 1986-08-14 | Sandoz-Patent-GmbH, 7850 Lörrach | Spiro-oxothiolane, ihre herstellung und verwendung |
| NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
| DE3789039T2 (de) * | 1986-06-27 | 1994-06-09 | Beecham Group Plc | Verbrückte bicyclische N-heterocyclische Verbindungen. |
| HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
| US4707484A (en) * | 1986-11-25 | 1987-11-17 | Hoffmann-La Roche Inc. | Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives |
| NZ227684A (en) * | 1988-01-30 | 1991-07-26 | Merck Sharp & Dohme | Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions |
-
1988
- 1988-04-11 GB GB888808433A patent/GB8808433D0/en active Pending
-
1989
- 1989-04-03 NZ NZ228583A patent/NZ228583A/xx unknown
- 1989-04-03 IL IL89822A patent/IL89822A0/xx unknown
- 1989-04-03 FI FI891584A patent/FI891584A/fi not_active Application Discontinuation
- 1989-04-04 US US07/333,076 patent/US4940703A/en not_active Expired - Fee Related
- 1989-04-06 ES ES89200862T patent/ES2061933T3/es not_active Expired - Lifetime
- 1989-04-06 DE DE68913327T patent/DE68913327T2/de not_active Expired - Fee Related
- 1989-04-06 AT AT89200862T patent/ATE102205T1/de not_active IP Right Cessation
- 1989-04-06 EP EP89200862A patent/EP0337547B1/en not_active Expired - Lifetime
- 1989-04-07 PT PT90223A patent/PT90223B/pt active IP Right Grant
- 1989-04-08 KR KR1019890004644A patent/KR900016202A/ko not_active Application Discontinuation
- 1989-04-10 JP JP1088177A patent/JPH01305092A/ja active Pending
- 1989-04-10 AU AU32632/89A patent/AU617785B2/en not_active Ceased
- 1989-04-10 IE IE891137A patent/IE891137L/xx unknown
- 1989-04-10 ZA ZA892587A patent/ZA892587B/xx unknown
- 1989-04-10 DK DK170489A patent/DK170489A/da not_active IP Right Cessation
- 1989-04-10 NO NO89891471A patent/NO891471L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ228583A (en) | 1990-02-26 |
| GB8808433D0 (en) | 1988-05-11 |
| ES2061933T3 (es) | 1994-12-16 |
| PT90223B (pt) | 1994-07-29 |
| ATE102205T1 (de) | 1994-03-15 |
| FI891584A0 (fi) | 1989-04-03 |
| DK170489A (da) | 1989-10-12 |
| US4940703A (en) | 1990-07-10 |
| NO891471L (no) | 1989-10-12 |
| AU617785B2 (en) | 1991-12-05 |
| PT90223A (pt) | 1989-11-10 |
| AU3263289A (en) | 1989-10-12 |
| FI891584A (fi) | 1989-10-12 |
| NO891471D0 (no) | 1989-04-10 |
| EP0337547B1 (en) | 1994-03-02 |
| DE68913327T2 (de) | 1994-07-28 |
| EP0337547A1 (en) | 1989-10-18 |
| DE68913327D1 (de) | 1994-04-07 |
| IE891137L (en) | 1989-10-11 |
| IL89822A0 (en) | 1989-12-15 |
| JPH01305092A (ja) | 1989-12-08 |
| KR900016202A (ko) | 1990-11-12 |
| ZA892587B (en) | 1990-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| AHB | Application shelved due to non-payment | ||
| PBP | Patent lapsed |