FI891584A7 - Spirocykliska foereningar med femledade ringar vilka innehaoller tvao heteroatomer. - Google Patents

Spirocykliska foereningar med femledade ringar vilka innehaoller tvao heteroatomer. Download PDF

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Publication number
FI891584A7
FI891584A7 FI891584A FI891584A FI891584A7 FI 891584 A7 FI891584 A7 FI 891584A7 FI 891584 A FI891584 A FI 891584A FI 891584 A FI891584 A FI 891584A FI 891584 A7 FI891584 A7 FI 891584A7
Authority
FI
Finland
Prior art keywords
spirocykliska
heteratomer
femledade
ringar
tvao
Prior art date
Application number
FI891584A
Other languages
English (en)
Other versions
FI891584A0 (fi
Inventor
Raymond Baker
Clare O Kneen
John Saunders
Christopher Swain
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of FI891584A0 publication Critical patent/FI891584A0/fi
Publication of FI891584A7 publication Critical patent/FI891584A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Addiction (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Luminescent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI891584A 1988-04-11 1989-04-03 Spirocykliska foereningar med femledade ringar vilka innehaoller tvao heteroatomer. FI891584A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808433A GB8808433D0 (en) 1988-04-11 1988-04-11 Therapeutic agents

Publications (2)

Publication Number Publication Date
FI891584A0 FI891584A0 (fi) 1989-04-03
FI891584A7 true FI891584A7 (fi) 1989-10-12

Family

ID=10634939

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891584A FI891584A7 (fi) 1988-04-11 1989-04-03 Spirocykliska foereningar med femledade ringar vilka innehaoller tvao heteroatomer.

Country Status (17)

Country Link
US (1) US4940703A (fi)
EP (1) EP0337547B1 (fi)
JP (1) JPH01305092A (fi)
KR (1) KR900016202A (fi)
AT (1) ATE102205T1 (fi)
AU (1) AU617785B2 (fi)
DE (1) DE68913327T2 (fi)
DK (1) DK170489A (fi)
ES (1) ES2061933T3 (fi)
FI (1) FI891584A7 (fi)
GB (1) GB8808433D0 (fi)
IE (1) IE891137L (fi)
IL (1) IL89822A0 (fi)
NO (1) NO891471L (fi)
NZ (1) NZ228583A (fi)
PT (1) PT90223B (fi)
ZA (1) ZA892587B (fi)

Families Citing this family (25)

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US5053412A (en) * 1990-04-10 1991-10-01 Israel Institute For Biological Research Spiro nitrogen-bridged heterocyclic compounds
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical compositions containing compounds with bridged and unbridged heterocyclic groups, spiro-connected with oxazoline and thiazoline groups, and some new such compounds
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
AU701227B2 (en) * 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
CZ289512B6 (cs) * 1994-08-24 2002-02-13 Astra Aktiebolag Spiro-azabicyklické sloučeniny pouľitelné při terapii
CZ82698A3 (cs) * 1995-09-18 1998-08-12 Glaxo Group Limited Použití antagonistů 5-HT3 receptorů pro výrobu farmaceutického prostředku k léčení diskinese
US8309577B2 (en) 2008-04-23 2012-11-13 Bristol-Myers Squibb Company Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
US7863291B2 (en) 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
WO2010084499A2 (en) * 2009-01-26 2010-07-29 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
RU2608458C2 (ru) 2009-05-20 2017-01-18 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Антагонисты серотониновых 5-нт3-рецепторов для применения при лечении вестибулярных нарушений с повреждениями
US8507516B2 (en) 2009-10-28 2013-08-13 Bristol-Myers Squibb Company Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
US8278320B2 (en) 2009-10-28 2012-10-02 Bristol-Myers Squibb Company Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
MX2012004560A (es) * 2009-10-29 2012-05-08 Bristol Myers Squibb Co Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7.
WO2011137313A1 (en) 2010-04-30 2011-11-03 Bristol-Myers Squibb Company Aza-bicyclic amine n-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs
JP5714745B2 (ja) * 2014-04-28 2015-05-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物
WO2020180876A1 (en) * 2019-03-04 2020-09-10 Beth Israel Deaconess Medical Center, Inc. Orai channel inhibitors
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
PE20240687A1 (es) 2020-12-30 2024-04-10 Tyra Biosciences Inc Compuestos de indazol como inhibidores de cinasas

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646053A (en) * 1970-05-18 1972-02-29 American Cyanamid Co Certain-(2-amino-4-thiazolyl)indoles
JPS4917534B1 (fi) * 1970-10-06 1974-05-01
GB1301254A (fi) * 1971-07-08 1972-12-29
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
AT357555B (de) * 1975-11-11 1980-07-25 Mundipharma Ag Verfahren zum herstellen von neuen spiro-(1,3- dioxolan-4,3')chinuclidinen, ihren salzen und isomeren
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4342769A (en) * 1978-10-02 1982-08-03 Schering Corporation 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
EP0083566A1 (en) * 1980-04-10 1983-07-13 Sandoz Ag Isoxazolyl indoles
US4332804A (en) * 1981-03-23 1982-06-01 Syntex (U.S.A.) Inc. 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
DE3218172A1 (de) * 1982-05-14 1983-11-17 Hoechst Ag, 6230 Frankfurt Polyalkyldiazaspirodecanderivate, verfahren zu ihrer herstellung und ihre verwendung als stabilisatoren
DE3504284A1 (de) * 1985-02-08 1986-08-14 Sandoz-Patent-GmbH, 7850 Lörrach Spiro-dithiolane, ihre herstellung und verwendung
DE3501225A1 (de) * 1985-01-16 1986-07-24 Sandoz-Patent-GmbH, 7850 Lörrach Spirodioxolane, ihre herstellung und verwendung
DE3504286A1 (de) * 1985-02-08 1986-08-14 Sandoz-Patent-GmbH, 7850 Lörrach Spiro-oxothiolane, ihre herstellung und verwendung
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
AU3263289A (en) 1989-10-12
DE68913327T2 (de) 1994-07-28
PT90223A (pt) 1989-11-10
AU617785B2 (en) 1991-12-05
NO891471L (no) 1989-10-12
IE891137L (en) 1989-10-11
EP0337547B1 (en) 1994-03-02
ATE102205T1 (de) 1994-03-15
DK170489D0 (da) 1989-04-10
JPH01305092A (ja) 1989-12-08
FI891584A0 (fi) 1989-04-03
PT90223B (pt) 1994-07-29
NZ228583A (en) 1990-02-26
KR900016202A (ko) 1990-11-12
EP0337547A1 (en) 1989-10-18
NO891471D0 (no) 1989-04-10
GB8808433D0 (en) 1988-05-11
ZA892587B (en) 1990-03-28
DK170489A (da) 1989-10-12
ES2061933T3 (es) 1994-12-16
US4940703A (en) 1990-07-10
IL89822A0 (en) 1989-12-15
DE68913327D1 (de) 1994-04-07

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Legal Events

Date Code Title Description
FA Application withdrawn [patent]

Owner name: MERCK SHARP & DOHME LIMITED