MX2012004560A - Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7. - Google Patents

Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7.

Info

Publication number
MX2012004560A
MX2012004560A MX2012004560A MX2012004560A MX2012004560A MX 2012004560 A MX2012004560 A MX 2012004560A MX 2012004560 A MX2012004560 A MX 2012004560A MX 2012004560 A MX2012004560 A MX 2012004560A MX 2012004560 A MX2012004560 A MX 2012004560A
Authority
MX
Mexico
Prior art keywords
alpha
acetylcholine receptor
receptor ligands
nicotinic acetylcholine
compounds
Prior art date
Application number
MX2012004560A
Other languages
English (en)
Inventor
John E Macor
Dalton King
Richard E Olson
James H Ii Cook
Ivar M Mcdonald
Nenghui Wang
F Christopher Zusi
Christiana I Iwuagwu
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2012004560A publication Critical patent/MX2012004560A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de la fórmula (Ver Formula) incluyendo sus sales, así como composiciones y métodos para usar los compuestos. Los compuestos son ligandos para el receptor nicotínico 7 y pueden ser útiles para el tratamiento de varios trastornos del sistema nervioso central, especialmente trastornos afectivos y neurodegenerativos.
MX2012004560A 2009-10-29 2009-10-29 Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7. MX2012004560A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/062492 WO2011053292A1 (en) 2009-10-29 2009-10-29 Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands

Publications (1)

Publication Number Publication Date
MX2012004560A true MX2012004560A (es) 2012-05-08

Family

ID=41361291

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004560A MX2012004560A (es) 2009-10-29 2009-10-29 Compuestos de quinuclidina como ligandos del receptor de acetilcolina nicotinico alfa-7.

Country Status (14)

Country Link
EP (1) EP2493892B1 (es)
JP (1) JP5619907B2 (es)
KR (1) KR20120099060A (es)
CN (1) CN102791718B (es)
AU (1) AU2009354790A1 (es)
BR (1) BR112012010054A2 (es)
CA (1) CA2779177C (es)
EA (1) EA201270610A1 (es)
ES (1) ES2544970T3 (es)
IL (1) IL219366A0 (es)
MX (1) MX2012004560A (es)
NZ (1) NZ600240A (es)
TN (1) TN2012000191A1 (es)
WO (1) WO2011053292A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY170236A (en) 2010-10-06 2019-07-11 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
KR102148355B1 (ko) * 2012-07-27 2020-08-26 사토 파머슈티컬 가부시키가이샤 디플루오로메틸렌 화합물
US10174052B2 (en) * 2014-11-04 2019-01-08 Bristol-Myers Squibb Company Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
JP7032903B2 (ja) * 2016-10-12 2022-03-09 田辺三菱製薬株式会社 スルホンアミド化合物の製造方法
CN116217571A (zh) * 2023-03-28 2023-06-06 上海锐谱医药科技有限公司 一种制备药物砌块1,2,4-三唑并[4,3-a]吡啶-3-胺的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
KR20070090922A (ko) * 2004-12-15 2007-09-06 아스트라제네카 아베 니코틴성 아세틸콜린 수용체 리간드
ITMI20061279A1 (it) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche
US7863291B2 (en) * 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands

Also Published As

Publication number Publication date
CN102791718A (zh) 2012-11-21
NZ600240A (en) 2014-04-30
KR20120099060A (ko) 2012-09-06
JP2013509405A (ja) 2013-03-14
BR112012010054A2 (pt) 2016-05-24
EA201270610A1 (ru) 2013-02-28
ES2544970T3 (es) 2015-09-07
IL219366A0 (en) 2012-06-28
CN102791718B (zh) 2015-11-25
TN2012000191A1 (en) 2013-12-12
WO2011053292A1 (en) 2011-05-05
EP2493892A1 (en) 2012-09-05
AU2009354790A1 (en) 2012-06-14
CA2779177A1 (en) 2011-05-05
EP2493892B1 (en) 2015-07-01
CA2779177C (en) 2016-08-30
JP5619907B2 (ja) 2014-11-05

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