MX347917B - Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso. - Google Patents

Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.

Info

Publication number
MX347917B
MX347917B MX2014010584A MX2014010584A MX347917B MX 347917 B MX347917 B MX 347917B MX 2014010584 A MX2014010584 A MX 2014010584A MX 2014010584 A MX2014010584 A MX 2014010584A MX 347917 B MX347917 B MX 347917B
Authority
MX
Mexico
Prior art keywords
imidazo
pyridazine
compositions
based compounds
disclosed
Prior art date
Application number
MX2014010584A
Other languages
English (en)
Other versions
MX2014010584A (es
Inventor
Gordon Carson Kenneth
Cianchetta Giovanni
Bi Yingzhi
Alan Green Michael
Kumi Godwin
Liang Zhi
Jade Liu Ying
Main Alan
Zhang Yulian
Gregory Zipp Glenn
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2014010584A publication Critical patent/MX2014010584A/es
Publication of MX347917B publication Critical patent/MX347917B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Se describen compuestos a base de imidazo[1,2-b]piridazina de la fórmula: (ver fórmula) en donde R1, R2 y R3 se definen en la presente. También se describen composiciones que comprenden los compuestos y sus métodos de uso para tratar, manejar y/o prevenir enfermedades y trastornos mediados por la actividad de cinasa 1 asociada al adaptador.
MX2014010584A 2012-03-09 2013-03-05 Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso. MX347917B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261608758P 2012-03-09 2012-03-09
PCT/US2013/029043 WO2013134219A1 (en) 2012-03-09 2013-03-05 Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof

Publications (2)

Publication Number Publication Date
MX2014010584A MX2014010584A (es) 2014-09-18
MX347917B true MX347917B (es) 2017-05-17

Family

ID=48014284

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014010584A MX347917B (es) 2012-03-09 2013-03-05 Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.

Country Status (20)

Country Link
US (3) US8969565B2 (es)
EP (1) EP2822559B1 (es)
JP (1) JP6418949B2 (es)
KR (1) KR102085121B1 (es)
CN (1) CN104470523B (es)
AR (1) AR090291A1 (es)
AU (1) AU2013230119B2 (es)
BR (1) BR112014022271B1 (es)
CA (1) CA2866164C (es)
ES (1) ES2676826T3 (es)
HK (1) HK1203407A1 (es)
IL (1) IL234485A (es)
MX (1) MX347917B (es)
NZ (1) NZ630719A (es)
RU (1) RU2014140739A (es)
SG (1) SG11201405563VA (es)
TW (1) TW201341385A (es)
UY (1) UY34669A (es)
WO (1) WO2013134219A1 (es)
ZA (1) ZA201406148B (es)

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Also Published As

Publication number Publication date
TW201341385A (zh) 2013-10-16
MX2014010584A (es) 2014-09-18
US20170057964A1 (en) 2017-03-02
EP2822559B1 (en) 2018-05-02
UY34669A (es) 2013-10-31
JP6418949B2 (ja) 2018-11-07
AR090291A1 (es) 2014-11-05
BR112014022271B1 (pt) 2021-09-21
HK1203407A1 (en) 2015-10-30
KR20140138865A (ko) 2014-12-04
EP2822559A1 (en) 2015-01-14
AU2013230119A1 (en) 2014-09-25
KR102085121B1 (ko) 2020-03-05
SG11201405563VA (en) 2014-10-30
CA2866164A1 (en) 2013-09-12
CA2866164C (en) 2020-07-07
NZ630719A (en) 2017-01-27
ZA201406148B (en) 2016-06-29
WO2013134219A1 (en) 2013-09-12
US8969565B2 (en) 2015-03-03
IL234485A (en) 2017-02-28
CN104470523B (zh) 2017-07-11
JP2015509534A (ja) 2015-03-30
CN104470523A (zh) 2015-03-25
ES2676826T3 (es) 2018-07-25
US20160024093A1 (en) 2016-01-28
BR112014022271A2 (es) 2017-06-20
RU2014140739A (ru) 2016-04-27
AU2013230119B2 (en) 2017-02-23
US20130245021A1 (en) 2013-09-19

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