AR090291A1 - Compuestos basados en la imidazo[1,2-b]piridazina, composiciones que la comprenden y metodos que los utilizan - Google Patents

Compuestos basados en la imidazo[1,2-b]piridazina, composiciones que la comprenden y metodos que los utilizan

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Publication number
AR090291A1
AR090291A1 ARP130100764A ARP130100764A AR090291A1 AR 090291 A1 AR090291 A1 AR 090291A1 AR P130100764 A ARP130100764 A AR P130100764A AR P130100764 A ARP130100764 A AR P130100764A AR 090291 A1 AR090291 A1 AR 090291A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
halo
cyano
or1c
hydrocarbyl
Prior art date
Application number
ARP130100764A
Other languages
English (en)
Inventor
Bi Yingzhi
Gordon Carson Kenneth
Cianchetta Giovanni
Alan Green Michael
Kumi Godwin
Liang Zhi
Jade Liu Ying
Main Alan
Zhang Yulian
Gregory Zipp Glenn
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of AR090291A1 publication Critical patent/AR090291A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

También se revelan composiciones que comprenden a dichos compuestos reivindicados. Trastornos del SNC (Alzheimer, Parkinson). Reivindicación 1: Un método para inhibir la actividad de una quinasa asociada a adaptador 1 (AAK1), que comprende poner en contacto la AAK1 con un compuesto de la fórmula (1) o con una sal farmacéuticamente aceptable del mismo, en donde: R¹ es R¹A o hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R¹A; cada R¹A es, de manera independiente, -OR¹C, -N(R¹C)₂, -C(O)R¹C, -C(O)OR¹C, -C(O)N(R¹C)₂, -N(R¹C)C(O)OR¹C, ciano, halo, hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R¹B; cada R¹B es, de manera independiente, -OR¹C, -N(R¹C)₂, -C(O)R¹C, -C(O)OR¹C, C(O)N(R¹C)₂, -N(R¹C)C(O)OR¹C, ciano o halo; cada R¹C es, de manera independiente, hidrógeno o hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más de ciano, halo o hidroxilo; R² es -NR²AR²B, en donde R²A es hidrógeno y R²B es hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R²C; o R²A y R²B se toman juntos para formar un heterociclo de 4 - 7 miembros, opcionalmente sustituido, con uno o más R²C; cada R²C es, de manera independiente, -OR²D, -N(R²D)₂, -C(O)R²D, -C(O)OR²D, -C(O)N(R²D)₂, -N(R²D)C(O)OR²D, ciano, halo, hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más amino, ciano, halo, hidroxilo o R²D; cada R²D es, de manera independiente, hidrógeno o hidrocarbilo C₁₋₁₂ o heterocarbilo de 2 - 12 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más de amino, ciano, halo o hidroxilo; y R³ es hidrógeno o alquilo C₁₋₆, opcionalmente sustituido, con uno o más de ciano, halo o hidroxilo.
ARP130100764A 2012-03-09 2013-03-11 Compuestos basados en la imidazo[1,2-b]piridazina, composiciones que la comprenden y metodos que los utilizan AR090291A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261608758P 2012-03-09 2012-03-09

Publications (1)

Publication Number Publication Date
AR090291A1 true AR090291A1 (es) 2014-11-05

Family

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Family Applications (1)

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Country Status (20)

Country Link
US (3) US8969565B2 (es)
EP (1) EP2822559B1 (es)
JP (1) JP6418949B2 (es)
KR (1) KR102085121B1 (es)
CN (1) CN104470523B (es)
AR (1) AR090291A1 (es)
AU (1) AU2013230119B2 (es)
BR (1) BR112014022271B1 (es)
CA (1) CA2866164C (es)
ES (1) ES2676826T3 (es)
HK (1) HK1203407A1 (es)
IL (1) IL234485A (es)
MX (1) MX347917B (es)
NZ (1) NZ630719A (es)
RU (1) RU2014140739A (es)
SG (1) SG11201405563VA (es)
TW (1) TW201341385A (es)
UY (1) UY34669A (es)
WO (1) WO2013134219A1 (es)
ZA (1) ZA201406148B (es)

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MX2014010584A (es) 2014-09-18
IL234485A (en) 2017-02-28
US20170057964A1 (en) 2017-03-02
SG11201405563VA (en) 2014-10-30
AU2013230119A1 (en) 2014-09-25
CA2866164C (en) 2020-07-07
US20130245021A1 (en) 2013-09-19
WO2013134219A1 (en) 2013-09-12
US8969565B2 (en) 2015-03-03
ES2676826T3 (es) 2018-07-25
EP2822559B1 (en) 2018-05-02
EP2822559A1 (en) 2015-01-14
UY34669A (es) 2013-10-31
CN104470523A (zh) 2015-03-25
TW201341385A (zh) 2013-10-16
KR102085121B1 (ko) 2020-03-05
US20160024093A1 (en) 2016-01-28
HK1203407A1 (en) 2015-10-30
AU2013230119B2 (en) 2017-02-23
RU2014140739A (ru) 2016-04-27
CN104470523B (zh) 2017-07-11
NZ630719A (en) 2017-01-27
BR112014022271B1 (pt) 2021-09-21
KR20140138865A (ko) 2014-12-04
JP6418949B2 (ja) 2018-11-07
MX347917B (es) 2017-05-17
CA2866164A1 (en) 2013-09-12
BR112014022271A2 (es) 2017-06-20
JP2015509534A (ja) 2015-03-30
ZA201406148B (en) 2016-06-29

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