CU24434B1 - Compuestos derivados de n-(1,5-dimetil-3-oxo-2,3-dihidro-1h-pirazol-4-il)-4-metil-5-isoxazol-3-carboxamida activos como inhibidores selectivos de smurf-1 - Google Patents
Compuestos derivados de n-(1,5-dimetil-3-oxo-2,3-dihidro-1h-pirazol-4-il)-4-metil-5-isoxazol-3-carboxamida activos como inhibidores selectivos de smurf-1Info
- Publication number
- CU24434B1 CU24434B1 CU2016000166A CU20160166A CU24434B1 CU 24434 B1 CU24434 B1 CU 24434B1 CU 2016000166 A CU2016000166 A CU 2016000166A CU 20160166 A CU20160166 A CU 20160166A CU 24434 B1 CU24434 B1 CU 24434B1
- Authority
- CU
- Cuba
- Prior art keywords
- smurf
- isoxazole
- dihydro
- oxo
- dimethyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
<p>La presente invención proporciona compuestos derivados de N-(1,5-dimetil-3-oxo-2,3-dihidro-1h-pirazol-4-il)-4-metil-5-isoxazol-3-carboxamida de fórmula I o una sal farmacéuticamente aceptable del mismo; activos como inhibidores selectivos Smurf-1;</p> <p>ESPACIO PARA FÓRMULA I</p> <p>Un método para la elaboración de los compuestos de la invención, y sus usos terapéuticos. La presente invención proporciona además una combinación de agentes farmacológicamente activos y una composición farmacéutica.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14168303 | 2014-05-14 | ||
| PCT/US2015/030817 WO2015175796A1 (en) | 2014-05-14 | 2015-05-14 | Carboxamide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160166A7 CU20160166A7 (es) | 2017-03-03 |
| CU24434B1 true CU24434B1 (es) | 2019-09-04 |
Family
ID=50735903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2016000166A CU24434B1 (es) | 2014-05-14 | 2015-05-14 | Compuestos derivados de n-(1,5-dimetil-3-oxo-2,3-dihidro-1h-pirazol-4-il)-4-metil-5-isoxazol-3-carboxamida activos como inhibidores selectivos de smurf-1 |
Country Status (38)
| Country | Link |
|---|---|
| US (6) | US9403810B2 (es) |
| EP (1) | EP3143018B1 (es) |
| JP (1) | JP6523338B2 (es) |
| KR (3) | KR102534033B1 (es) |
| CN (1) | CN106661012B (es) |
| AP (1) | AP2016009550A0 (es) |
| AR (1) | AR100440A1 (es) |
| AU (1) | AU2015259083B2 (es) |
| BR (1) | BR112016026552B1 (es) |
| CA (1) | CA2948543C (es) |
| CL (1) | CL2016002839A1 (es) |
| CR (1) | CR20160527A (es) |
| CU (1) | CU24434B1 (es) |
| CY (1) | CY1124251T1 (es) |
| DK (1) | DK3143018T3 (es) |
| EA (1) | EA030938B1 (es) |
| ES (1) | ES2874882T3 (es) |
| HR (1) | HRP20210783T1 (es) |
| HU (1) | HUE054590T2 (es) |
| IL (1) | IL248785B (es) |
| JO (1) | JO3610B1 (es) |
| LT (1) | LT3143018T (es) |
| MA (1) | MA39983B1 (es) |
| MX (1) | MX374383B (es) |
| MY (1) | MY186598A (es) |
| PE (1) | PE20171443A1 (es) |
| PH (1) | PH12016502246B1 (es) |
| PL (1) | PL3143018T3 (es) |
| PT (1) | PT3143018T (es) |
| RS (1) | RS61874B1 (es) |
| SG (1) | SG11201609217UA (es) |
| SI (1) | SI3143018T1 (es) |
| SV (1) | SV2016005313A (es) |
| TN (1) | TN2016000489A1 (es) |
| TW (2) | TWI714528B (es) |
| UY (1) | UY36124A (es) |
| WO (1) | WO2015175796A1 (es) |
| ZA (1) | ZA201607658B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9403810B2 (en) | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
| TW201623288A (zh) | 2014-05-14 | 2016-07-01 | 諾華公司 | 甲醯胺衍生物 |
| KR102731924B1 (ko) * | 2017-11-01 | 2024-11-19 | 브리스톨-마이어스 스큅 컴퍼니 | 파르네소이드 x 수용체 조정제로서의 스피로시클릭 화합물 |
| CN108689976B (zh) * | 2018-07-23 | 2021-12-28 | 陕西师范大学 | 5-磺基水杨酸协同二氯二茂钛催化合成4-碘代四氢吡喃衍生物的方法 |
| TW202216669A (zh) * | 2020-07-09 | 2022-05-01 | 美商必治妥美雅史谷比公司 | 吡唑啉酮甲醯基肽2受體促效劑 |
| CN116438200A (zh) | 2020-09-10 | 2023-07-14 | 普雷西里克斯公司 | 针对fap的抗体片段 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| JP2025517625A (ja) | 2022-05-02 | 2025-06-10 | プレシリックス・ナームローゼ・ベンノートシヤープ | プレターゲティング |
| WO2024242594A1 (ru) * | 2023-05-23 | 2024-11-28 | Общество С Ограниченной Ответственностью "Ифар" | Средство для лечения легочных гипертензий |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2655009A1 (de) * | 1976-12-04 | 1978-06-15 | Hoechst Ag | Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| AU782355B2 (en) * | 1999-06-11 | 2005-07-21 | Hsc Research And Development Limited Partnership | Antagonists of BMP and TGFbeta signalling pathways |
| US7354722B1 (en) | 1999-06-11 | 2008-04-08 | Signal Pharmaceuticals | Modulators of Smurf and BMP/TGFβ signaling pathways |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| GB0312368D0 (en) | 2003-05-30 | 2003-07-02 | Univ Aston | Novel ureido- and amido-pyrazolone derivatives |
| JP2007506741A (ja) * | 2003-09-23 | 2007-03-22 | メルク エンド カムパニー インコーポレーテッド | 向代謝性グルタミン酸受容体のピラゾール系調節剤 |
| US7291743B2 (en) | 2005-03-29 | 2007-11-06 | Geneblue Corporation | Isoxazole derivatives and methods of treating nitric oxide mediated diseases |
| WO2008121861A2 (en) | 2007-03-28 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Pyrazole and pyrrole compounds useful in treating iron disorders |
| WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
| US8211927B2 (en) | 2007-08-02 | 2012-07-03 | MSD, Oss B.V. | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators |
| AU2008289037B2 (en) | 2007-08-22 | 2012-03-01 | Novartis Ag | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2011151361A1 (en) | 2010-06-03 | 2011-12-08 | Glaxo Group Limited | Novel compounds |
| CN103380130B (zh) | 2011-02-18 | 2015-06-17 | 埃科特莱茵药品有限公司 | 用作为食欲素拮抗剂的新颖的吡唑和咪唑衍生物 |
| TW201623288A (zh) | 2014-05-14 | 2016-07-01 | 諾華公司 | 甲醯胺衍生物 |
| US20170088546A1 (en) * | 2014-05-14 | 2017-03-30 | Novartis Ag | Carboxamide inhibitors |
| US9403810B2 (en) | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
| EP3143021B1 (en) | 2014-05-14 | 2019-06-12 | Pfizer Inc | Pyrazolopyridines and pyrazolopyrimidines |
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2015
- 2015-05-13 US US14/711,684 patent/US9403810B2/en active Active
- 2015-05-13 TW TW104115287A patent/TWI714528B/zh active
- 2015-05-13 TW TW108119419A patent/TW201946921A/zh unknown
- 2015-05-14 KR KR1020167034559A patent/KR102534033B1/ko active Active
- 2015-05-14 HU HUE15725195A patent/HUE054590T2/hu unknown
- 2015-05-14 AU AU2015259083A patent/AU2015259083B2/en active Active
- 2015-05-14 MX MX2016014939A patent/MX374383B/es active IP Right Grant
- 2015-05-14 EP EP15725195.0A patent/EP3143018B1/en active Active
- 2015-05-14 SI SI201531605T patent/SI3143018T1/sl unknown
- 2015-05-14 CU CU2016000166A patent/CU24434B1/es unknown
- 2015-05-14 PE PE2017000546A patent/PE20171443A1/es unknown
- 2015-05-14 UY UY0001036124A patent/UY36124A/es active IP Right Grant
- 2015-05-14 KR KR1020267001924A patent/KR20260023080A/ko active Pending
- 2015-05-14 PL PL15725195T patent/PL3143018T3/pl unknown
- 2015-05-14 TN TN2016000489A patent/TN2016000489A1/en unknown
- 2015-05-14 EA EA201692300A patent/EA030938B1/ru not_active IP Right Cessation
- 2015-05-14 JP JP2016567570A patent/JP6523338B2/ja active Active
- 2015-05-14 DK DK15725195.0T patent/DK3143018T3/da active
- 2015-05-14 ES ES15725195T patent/ES2874882T3/es active Active
- 2015-05-14 BR BR112016026552-1A patent/BR112016026552B1/pt active IP Right Grant
- 2015-05-14 MY MYPI2016704043A patent/MY186598A/en unknown
- 2015-05-14 RS RS20210629A patent/RS61874B1/sr unknown
- 2015-05-14 AR ARP150101498A patent/AR100440A1/es active IP Right Grant
- 2015-05-14 WO PCT/US2015/030817 patent/WO2015175796A1/en not_active Ceased
- 2015-05-14 JO JOP/2015/0119A patent/JO3610B1/ar active
- 2015-05-14 PT PT157251950T patent/PT3143018T/pt unknown
- 2015-05-14 SG SG11201609217UA patent/SG11201609217UA/en unknown
- 2015-05-14 CA CA2948543A patent/CA2948543C/en active Active
- 2015-05-14 LT LTEP15725195.0T patent/LT3143018T/lt unknown
- 2015-05-14 KR KR1020237016401A patent/KR20230074827A/ko not_active Ceased
- 2015-05-14 CR CR20160527A patent/CR20160527A/es unknown
- 2015-05-14 MA MA39983A patent/MA39983B1/fr unknown
- 2015-05-14 HR HRP20210783TT patent/HRP20210783T1/hr unknown
- 2015-05-14 AP AP2016009550A patent/AP2016009550A0/en unknown
- 2015-05-14 CN CN201580038353.3A patent/CN106661012B/zh active Active
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2016
- 2016-06-16 US US15/184,730 patent/US10195181B2/en active Active
- 2016-11-06 IL IL248785A patent/IL248785B/en active IP Right Grant
- 2016-11-07 ZA ZA2016/07658A patent/ZA201607658B/en unknown
- 2016-11-09 CL CL2016002839A patent/CL2016002839A1/es unknown
- 2016-11-11 SV SV2016005313A patent/SV2016005313A/es unknown
- 2016-11-11 PH PH12016502246A patent/PH12016502246B1/en unknown
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2018
- 2018-12-21 US US16/230,033 patent/US20190381011A1/en not_active Abandoned
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2020
- 2020-05-14 US US16/874,595 patent/US20200268718A1/en not_active Abandoned
- 2020-11-04 US US17/089,064 patent/US11672782B2/en active Active
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2021
- 2021-06-04 CY CY20211100488T patent/CY1124251T1/el unknown
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2023
- 2023-05-16 US US18/317,990 patent/US20230301970A1/en active Pending
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