PE20161475A1 - Pirazolopiridinas y pirazolopirimidinas - Google Patents

Pirazolopiridinas y pirazolopirimidinas

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Publication number
PE20161475A1
PE20161475A1 PE2016002225A PE2016002225A PE20161475A1 PE 20161475 A1 PE20161475 A1 PE 20161475A1 PE 2016002225 A PE2016002225 A PE 2016002225A PE 2016002225 A PE2016002225 A PE 2016002225A PE 20161475 A1 PE20161475 A1 PE 20161475A1
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PE
Peru
Prior art keywords
phenyl
amino
ethyl
alkyl
pyrazolopyridines
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PE2016002225A
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English (en)
Inventor
Gavin Alistair Whitlock
Florian Michel Wakenhut
Joseph Walter Strohbach
Jotham Wadsworth Coe
Peter Jones
Christoph Martin Dehnhardt
Yogesh Anil Sabnis
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Pfizer
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53264695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161475(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PE20161475A1 publication Critical patent/PE20161475A1/es

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se refiere a un compuesto de formula I, donde: A y A’ son C o N; R y R0 son H, alquilo C1-C6, entre otros; R1 es H, halo o ciano; R2 y R2’ son H, alquilo C1-C6, ciano, entre otros; R3 es H, alquilo C1-C4, fenilo, entre otros; X es un enlace, -CO-, -CONH-, entre otros. Son compuestos preferidos: 4-({2-[etil(etilsulfonil)amino]bencil}amino)-6-[5-fluoro-4-hidroxi-2-(2,2,2-trifluoroetil)-fenil]-N-metil-1H-pirazolo[4,3-c]piridin-3-carboxamida; 4-({2-[etil(etilsulfonil)amino]bencil}amino)-6-[2-etil-5-fluoro-4-hidroxifenil]-N-metil-1H-pirazolo[4,3-c]piridin-3-carboxamida; entre otros. Dichos compuestos son derivados de 6-fenil-1H-pirazolopiridinas y 6-fenil-1H-pirazolopirimidinas que inhiben la Janus quinasa (JAK), siendo utiles en el tratamiento de condiciones alergicas y respiratorias tales como la enfermedad pulmonar obstructiva cronica (EPOC), entre otras.
PE2016002225A 2014-05-14 2015-04-30 Pirazolopiridinas y pirazolopirimidinas PE20161475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461993138P 2014-05-14 2014-05-14

Publications (1)

Publication Number Publication Date
PE20161475A1 true PE20161475A1 (es) 2017-01-08

Family

ID=53264695

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016002225A PE20161475A1 (es) 2014-05-14 2015-04-30 Pirazolopiridinas y pirazolopirimidinas

Country Status (29)

Country Link
US (2) US9518052B2 (es)
EP (1) EP3143021B1 (es)
JP (1) JP6663857B2 (es)
KR (1) KR20170002623A (es)
CN (1) CN106459048A (es)
AP (1) AP2016009562A0 (es)
AR (1) AR100438A1 (es)
AU (1) AU2015260905A1 (es)
CA (1) CA2948587C (es)
CL (1) CL2016002888A1 (es)
CR (1) CR20160525A (es)
CU (1) CU20160167A7 (es)
DO (1) DOP2016000298A (es)
EA (1) EA201650029A1 (es)
EC (1) ECSP16087271A (es)
ES (1) ES2737696T3 (es)
GE (1) GEP20186921B (es)
IL (1) IL248970A0 (es)
MD (1) MD20160121A2 (es)
MX (1) MX2016014878A (es)
NI (1) NI201600170A (es)
PE (1) PE20161475A1 (es)
PH (1) PH12016502228A1 (es)
SG (1) SG11201609139WA (es)
SV (1) SV2016005318A (es)
TN (1) TN2016000503A1 (es)
TW (1) TWI591067B (es)
UY (1) UY36121A (es)
WO (1) WO2015173683A1 (es)

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