EA201650029A1 - Пиразолопиридины и пиразолопиримидины - Google Patents

Пиразолопиридины и пиразолопиримидины

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Publication number
EA201650029A1
EA201650029A1 EA201650029A EA201650029A EA201650029A1 EA 201650029 A1 EA201650029 A1 EA 201650029A1 EA 201650029 A EA201650029 A EA 201650029A EA 201650029 A EA201650029 A EA 201650029A EA 201650029 A1 EA201650029 A1 EA 201650029A1
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Prior art keywords
compounds
derivatives
pharmaceutically acceptable
pyrazolopyridines
pyrazolopyrimidines
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EA201650029A
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English (en)
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Джотам Уодсворт Кое
Кристоф Мартин Денхардт
Питер Джонс
Йогеш Анил Сабнис
Джозеф Уолтер Строхбач
Флориан Мишель Уокенхат
Гэвин Алистер Уитлок
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Пфайзер Инк.
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Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA201650029A1 publication Critical patent/EA201650029A1/ru

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Abstract

Представленное изобретение относится к области фармацевтики, а именно касается производных пиразолопиридинов и пиразолопиримидинов, фармацевтических композиций, содержащих такие соединения, и их применения как лекарственных средств, а именно производных 6-фенил-1Н-пиразолопиридинов и производных 6-фенил-1Н-пиразолопиримидинов, которые являются ингибиторами Янус-киназ (JAK) и являются полезными для лечения аллергических и респираторных состояний, в частности хронического обструктивного заболевания легких. Представленное изобретение касается соединения формулы Iили его фармацевтически приемлемой соли, или фармацевтически приемлемого сольвата указанного соединения или фармацевтически приемлемой соли, где А и А' независимо представляют собой С или N, где С может быть незамещенным или замещенным галогеном или C-Салкилом, в котором R, R, R, R, Rи Rявляются определенными в данном документе, композиций, содержащих такие соединения, и применения таких соединения в лечении различных заболеваний, в частности астмы и ХОЗЛ.
EA201650029A 2014-05-14 2015-04-30 Пиразолопиридины и пиразолопиримидины EA201650029A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461993138P 2014-05-14 2014-05-14
PCT/IB2015/053174 WO2015173683A1 (en) 2014-05-14 2015-04-30 Pyrazolopyridines and pyrazolopyrimidines

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US (2) US9518052B2 (ru)
EP (1) EP3143021B1 (ru)
JP (1) JP6663857B2 (ru)
KR (1) KR20170002623A (ru)
CN (1) CN106459048A (ru)
AP (1) AP2016009562A0 (ru)
AR (1) AR100438A1 (ru)
AU (1) AU2015260905A1 (ru)
CA (1) CA2948587C (ru)
CL (1) CL2016002888A1 (ru)
CR (1) CR20160525A (ru)
CU (1) CU20160167A7 (ru)
DO (1) DOP2016000298A (ru)
EA (1) EA201650029A1 (ru)
EC (1) ECSP16087271A (ru)
ES (1) ES2737696T3 (ru)
GE (1) GEP20186921B (ru)
IL (1) IL248970A0 (ru)
MD (1) MD20160121A2 (ru)
MX (1) MX2016014878A (ru)
NI (1) NI201600170A (ru)
PE (1) PE20161475A1 (ru)
PH (1) PH12016502228A1 (ru)
SG (1) SG11201609139WA (ru)
SV (1) SV2016005318A (ru)
TN (1) TN2016000503A1 (ru)
TW (1) TWI591067B (ru)
UY (1) UY36121A (ru)
WO (1) WO2015173683A1 (ru)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20186921B (en) 2014-05-14 2018-11-12 Pfizer Pyrazolopyridines and pyrazolopyrimidines
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
PL3712152T3 (pl) 2015-11-03 2021-08-02 Topivert Pharma Limited Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
EP3831830A1 (en) 2015-11-03 2021-06-09 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
AR111242A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada que contienen una amida heterocíclica de 4 miembros como inhibidores de jak
BR112019022665A2 (pt) 2017-05-01 2020-05-19 Theravance Biopharma R&D Ip Llc métodos de tratamento usando um composto inibidor de jak
US10251874B2 (en) 2017-05-01 2019-04-09 Theravance Biopharma R&D Ip, Llc Crystalline forms of a JAK inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
EA038912B1 (ru) 2017-08-01 2021-11-09 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Пиразоло- и триазолобициклические соединения в качестве ингибиторов jak киназы
JP2021502400A (ja) 2017-11-03 2021-01-28 アクラリス セラピューティクス，インコーポレイテッド 置換ピロロピリミジンｊａｋ阻害剤ならびにこれを作製および使用する方法
MX2021001558A (es) 2018-08-10 2021-04-28 Aclaris Therapeutics Inc Inhibidores de itk de pirrolopirimidina.
CN110833555B (zh) * 2018-08-15 2023-03-24 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物在治疗溃疡性结肠炎的用途
AU2019336167A1 (en) 2018-09-04 2021-03-11 Theravance Biopharma R&D Ip, Llc Dimethyl amino azetidine amides as JAK inhibitors
US10844057B2 (en) 2018-09-04 2020-11-24 Theravance Biopharma R&D Ip, Llc Process for preparing JAK inhibitors and intermediates thereof
CN112703037B (zh) 2018-09-04 2023-10-20 施万生物制药研发Ip有限责任公司 作为jak抑制剂的5至7元杂环酰胺
SG11202103042XA (en) 2018-10-29 2021-04-29 Theravance Biopharma R&D Ip Llc 2-azabicyclo hexane compound as jak inhibitor
CA3125039A1 (en) 2019-01-23 2020-07-30 Theravance Biopharma R&D Ip, Llc Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors
MX2021010242A (es) 2019-02-25 2021-09-21 Henan Medinno Pharmaceutical Tech Co Ltd Compuesto inhibidor de jak y uso del mismo.
WO2020223728A1 (en) 2019-05-02 2020-11-05 Aclaris Therapeutics, Inc. Substituted pyrrolopyridines as jak inhibitors
WO2021022178A1 (en) * 2019-07-31 2021-02-04 Aclaris Therapeutics, Inc. Substituted sulfonamide pyrrolopyridines as jak inhibitors
EP4071145A4 (en) * 2019-12-30 2023-04-19 Liang Lu JAK INHIBITOR COMPOUND AND ITS USE
CN113101975B (zh) * 2020-01-13 2022-04-22 万华化学集团股份有限公司 一种多膦配体催化剂体系及其在乙烯齐聚反应的应用
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
CN111548269B (zh) * 2020-04-29 2023-10-27 兰州大学 一种二芳基甲烷结构化合物的制备方法
GB202010408D0 (en) * 2020-07-07 2020-08-19 Reviral Ltd Pharmaceutical compounds
CN116438200A (zh) 2020-09-10 2023-07-14 普雷西里克斯公司 针对fap的抗体片段
CN115557947B (zh) * 2021-07-02 2024-04-02 成都百裕制药股份有限公司 吡唑并[4,3-c]吡啶衍生物及其在医药上的应用
CN113480543B (zh) * 2021-07-07 2022-05-17 无锡市第二人民医院 2,6,8-多取代咪唑并[1,2-a]吡嗪及其合成方法和应用
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US20030139427A1 (en) * 2002-08-23 2003-07-24 Osi Pharmaceuticals Inc. Bicyclic pyrimidinyl derivatives and methods of use thereof
AR042064A1 (es) 2002-11-19 2005-06-08 Takeda Pharmaceutical Compuestos de amina con actividad inhibidora de la union al receptor de somastotina
US20080234262A1 (en) * 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
JP4782239B2 (ja) 2007-04-18 2011-09-28 ファイザー・プロダクツ・インク 異常細胞増殖治療のためのスルホニルアミド誘導体
AP2010005234A0 (en) * 2007-10-16 2010-04-30 Wyeth Llc Thienopyrimidine and pyrazolopyrimidline compoundsand their use as MTOR kinase and P13 kinase inhib itors
WO2009062118A2 (en) * 2007-11-07 2009-05-14 Foldrx Pharmaceuticals, Inc. Modulation of protein trafficking
WO2009070524A1 (en) * 2007-11-27 2009-06-04 Wyeth Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors
CN102014914A (zh) * 2008-01-15 2011-04-13 惠氏有限责任公司 3h-[1,2,3]三唑并[4,5-d]嘧啶化合物、其作为mtor激酶和pi3激酶抑制剂的用途、以及它们的合成
WO2009097446A1 (en) * 2008-01-30 2009-08-06 Genentech, Inc. Pyrazolopyrimidine pi3k inhibitor compounds and methods of use
EP2280946B1 (en) * 2008-06-05 2016-02-10 Glaxo Group Limited 4-carboxamide indazole derivatives useful as inhibitors of p13-kinases
WO2009153261A1 (en) * 2008-06-18 2009-12-23 Solvay Pharmaceuticals Gmbh HYDROXYPHENYL-SUBSTITUTED PYRROLO[2,3d]PYRIMIDINE DERIVATIVES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
EP2361902A4 (en) 2008-11-21 2012-04-25 Astellas Pharma Inc 4,6-DIAMINONICOTINSÄUREAMIDVERBINDUNG
EP2408772B1 (en) * 2009-03-19 2015-07-01 Medical Research Council Technology Compounds
WO2012045195A1 (en) 2010-10-09 2012-04-12 Abbott Laboratories Pyrrolopyrimidines as fak and alk inhibiters for treatment of cancers and other diseases
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
GEP20186921B (en) 2014-05-14 2018-11-12 Pfizer Pyrazolopyridines and pyrazolopyrimidines

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